Gossypol toxicity from cottonseed products

Scientific World Journal

Volumn 2014, Issue , 2014, Pages

  Gadelha, Ivana Cristina N ^a   Fonseca, Nayanna Brunna S ^a   Oloris, Silvia Catarina S ^b   Melo, Marília M ^c   Soto Blanco, Benito ^c  

^a UNIVERSIDADE FEDERAL RURAL DO SEMI ÁRIDO   (Brazil)

^b FUNDAÇÃO EZEQUIEL DIAS   (Brazil)

^c FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GOSSYPOL;

ANOREXIA; APATHY; CONCENTRATION (PARAMETERS); GAMETOGENESIS; IMMUNOTOXICITY; LIVER INJURY; LIVER TOXICITY; NONHUMAN; PLANT PRODUCT; REPRODUCTIVE TOXICITY; RESPIRATORY DISTRESS; REVIEW; TOXICOKINETICS; WEAKNESS; WEIGHT GAIN; ANIMAL; ANIMAL FOOD; CHEMISTRY; DRUG EFFECTS; FEMALE; GENETICS; GOSSYPIUM; MALE; METABOLISM; PLANT SEED; REPRODUCTION; TOXICITY;

ANIMAL FEED; ANIMALS; FEMALE; GOSSYPIUM; GOSSYPOL; MALE; REPRODUCTION; SEEDS;

EID: 84901806306     PISSN: 23566140     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1155/2014/231635     Document Type: Review

References (171)

1. Soto-Blanco B., Spinosa H. S., Górniak S. L., Neto J. P., Gossipol e fatores antinutricionais da soja. Toxicologia Aplicada à MedicIna VeterInária 2008 Barueri, Brazil Manole 531 545
2. Borém A., Freire E. C., Cesar J., Penna V., Vianna P. A., Considerations about cotton gene escape in Brazil: a review. Crop Breeding and Applied Biotechnology 2003 3 4 315 332 10.12702/1984-7033.v03n04a13
3. Abou-Donia M. B., Physiological effects and metabolism of gossypol. Residue Reviews 1976 61 125 160 2-s2.0-0016916304
4. Rogers G. M., Poore M. H., Paschal J. C., Feeding cotton products to cattle. Veterinary Clinics of North America: Food Animal Practice 2002 18 2 267 294 2-s2.0-0036654194 10.1016/S0749-0720(02)00020-8
5. Kenar J. A., Reaction chemistry of gossypol and its derivatives. Journal of the American Oil Chemists' Society 2006 83 4 269 302 2-s2.0-33744490651 10.1007/s11746-006-1203-1 (Pubitemid 43798647)
6. Alexander J., Benford D., Cockburn A., Cravedi J., Dogliotti E., di Domenico A., Férnandez-cruz M. L., Fürst P., Fink-gremmels J., Galli C. L., Grandjean P., Gzyl J., Heinemeyer G., Mutti A., Schlatter J., van Leeuwen R., van Peteghem C., Verger P., Gossypol as undesirable substance in animal feed. EFSA Journal 2008 908 1 55
7. Percy R. G., Calhoun M. C., Kim H. L., Seed gossypol variation within Gossypium barbadense L. cotton. Crop Science 1996 36 1 193 197 2-s2.0-0030019021
8. Hron R. J. Sr., Kim H. L., Calhoun M. C., Fisher G. S., Determination of (+)-, (-)-, and total gossypol in cottonseed by high-performance liquid chromatography. Journal of the American Oil Chemists' Society 1999 76 11 1351 1355 2-s2.0-0033225380 (Pubitemid 30519214)
9. Lordelo M. M., Davis A. J., Calhoun M. C., Dowd M. K., Dale N. M., Relative toxicity of gossypol enantiomers in broilers. Poultry Science 2005 84 9 1376 1382 2-s2.0-24744436937 (Pubitemid 41291026)
10. Lordelo M. M., Calhoun M. C., Dale N. M., Dowd M. K., Davis A. J., Relative toxicity of gossypol enantiomers in laying and broiler breeder hens. Poultry Science 2007 86 3 582 590 2-s2.0-34250360325 (Pubitemid 47581098)
11. Kakani R., Gamboa D. A., Calhoun M. C., Haq A. U., Bailey C. A., Relative toxicity of cottonseed gossypol enantiomers in broilers. Open Toxicology Journal 2010 4 26 31 2-s2.0-80555136555
12. Wu D.-F., Yu Y.-W., Tang Z.-M., Wang M.-Z., Pharmacokinetic of (±)-, (+)-, and (-)-gossypol in humans and dogs. Clinical Pharmacology and Therapeutics 1986 39 6 613 618 2-s2.0-0022560339
13. Bailey C. A., Stipanovic R. D., Ziehr M. S., Haq A. U., Sattar M., Kubena L. F., Kim H. L., de Vieira R. M., Cottonseed with a high (+)- to (-)-gossypol enantiomer ratio favorable to broiler production. Journal of Agricultural and Food Chemistry 2000 48 11 5692 5695 2-s2.0-0033667330 10.1021/jf000211n
14. Scheffler J. A., Romano G. B., Breeding and genetics: modifying gossypol in cotton (Gossypium hirsutum L.): a cost effective method for small seed samples. Journal of Cotton Science 2008 12 3 202 209 2-s2.0-56749090760
15. Calhoun M. C., Kuhlmann S. K., Balwin B. C., Assessing the gossypol status of cattle fed cotton feed products. 1995 Proceedings of the Pacific Northwest Animal Nutrition Conference 147A 158A
16. Stipanovic R. D., Puckhaber L. S., Liu J., Bell A. A., Total and percent atropisomers of Gossypol and Gossypol-6-methyl ether in seeds from Pima cottons and accessions of Gossypium barbadense L. Journal of Agricultural and Food Chemistry 2009 57 2 566 571 2-s2.0-59849128632 10.1021/jf802756e
17. Bressani R., Jarquín R., Elías L. G., Free and total gossypol, epsilon-amino lysine, and biological evaluation of cottonseed meals and flours in Central America. Journal of Agricultural and Food Chemistry 1964 12 3 278 282 2-s2.0-33947486504
18. Fernandez S. R., Zhang Y., Parsons C. M., Dietary formulation with cottonseed meal on a total amino acid versus a digestible amino acid basis. Poultry Science 1995 74 7 1168 1179 2-s2.0-0029336853
19. Pons W. A. Jr., Hoffpauir C. L., Hopper T. H., Gossypol in cottonseed: influence of variety of cottonseed and environment. Journal of Agricultural and Food Chemistry 1953 1 18 1115 1118 2-s2.0-0004800383
20. Randel R. D., Chase C. C. Jr., Wyse S. J., Effects of gossypol and cottonseed products on reproduction of mammals. Journal of Animal Science 1992 70 5 1628 1638 2-s2.0-0026862654
21. Price W. D., Lovell R. A., McChesney D. G., Naturally occurring toxins in feedstuffs: center for veterinary medicine perspective. Journal of Animal Science 1993 71 9 2556 2562 2-s2.0-0027661837
22. Nicholson S. S., Gupta R. C., Cottonseed toxicity. VeterInary Toxicology: Basic and Clinical Principles 2012 2nd London, UK Academic Press 1161 1165
23. Polsky B., Segal S. J., Baron P. A., Gold J. W. M., Ueno H., Armstrong D., Inactivation of human immunodeficiency virus in vitro by gossypol. Contraception 1989 39 6 579 587 2-s2.0-0024410087 (Pubitemid 19148590)
24. Yang J., Zhang F., Li J., Chen G., Wu S., Ouyang W., Pan W., Yu R., Yang J., Tien P., Synthesis and antiviral activities of novel gossypol derivatives. Bioorganic and Medicinal Chemistry Letters 2012 22 3 1415 1420 2-s2.0-84856212593 10.1016/j.bmcl.2011.12.076
25. Yang J., Chen G., Li L. L., Pan W., Zhang F., Yang J., Wu S., Tien P., Synthesis and anti-H5N1 activity of chiral gossypol derivatives and its analogs implicated by a viral entry blocking mechanism. Bioorganic & Medicinal Chemistry Letters 2013 23 9 2619 2623 10.1016/j.bmcl.2013.02.101
26. Margalith P., Inhibitory effect of gossypol on microorganisms. Applied Microbiology 1967 15 4 952 953 2-s2.0-0014107127
27. Yildirim-Aksoy P., Lim C., Dowd M. K., Wan P. J., Klesius P. H., Shoemaker C., In vitro inhibitory effect of gossypol from gossypol-acetic acid, and (+)- and (-)-isomers of gossypol on the growth of Edwardsiella ictaluri. Journal of Applied Microbiology 2004 97 1 87 92 2-s2.0-3042742556 10.1111/j.1365-2672.2004.02273.x (Pubitemid 38869885)
28. Turco E., Vizzuso C., Franceschini S., Ragazzi A., Stefanini F. M., The in vitro effect of gossypol and its interaction with salts on conidial germination and viability of Fusarium oxysporum sp. vasinfectum isolates. Journal of Applied Microbiology 2007 103 6 2370 2381 2-s2.0-36549058297 10.1111/j.1365-2672.2007.03503.x (Pubitemid 350191196)
29. Anna Y., Medentsev A. G., Krupyanko V. I., Gossypol inhibits electron transport and stimulates ROS generation in yarrowia lipolytica mitochondria. Open Biochemistry Journal 2012 6 11 15 2-s2.0-84859509849 10.2174/ 1874091X01206010011
30. Balakrishnan K., Wierda W. G., Keating M. J., Gandhi V., Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. Blood 2008 112 5 1971 1980 2-s2.0-52649179285 10.1182/blood-2007-12-126946
31. Johnson P. W. M., New targets for lymphoma treatment. Annals of Oncology 2008 19 4 iv56 iv59 2-s2.0-48149112664 10.1093/annonc/mdn198
32. Wang X., Wang J., Wong S. C. H., Chow L. S. N., Nicholls J. M., Wong Y. C., Liu Y., Kwong D. L. W., Sham J. S. T., Tsao S. W., Cytotoxic effect of gossypol on colon carcinoma cells. Life Sciences 2000 67 22 2663 2671 2-s2.0-0034692871
33. van Poznak C., Seidman A. D., Reidenberg M. M., Moasser M. M., Sklarin N., van Zee K., Borgen P., Gollub M., Bacotti D., Yao T.-J., Bloch R., Ligueros M., Sonenberg M., Norton L., Hudis C., Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial. Breast Cancer Research and Treatment 2001 66 3 239 248 2-s2.0-0034922672 10.1023/A:1010686204736 (Pubitemid 32675026)
34. Ye W., Chang H.-L., Wang L.-S., Huang Y.-W., Shu S., Dowd M. K., Wan P. J., Sugimoto Y., Lin Y. C., Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil. Anticancer Research 2007 27 1 107 116 2-s2.0-33847650043 (Pubitemid 46363322)
35. Han M.-L., Wang Y.-F., Tang M.-Y., Ge Q.-S., Zhou L.-F., Zhu P.-D., Sun Y.-T., Gossypol in the treatment of endometriosis and uterine myoma. Contributions to Gynecology and Obstetrics 1987 16 268 270 2-s2.0-0023481826 (Pubitemid 18000891)
36. Jiang J., Slivova V., Jedinak A., Sliva D., Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF- B/AP-1 dependent- and independent-signaling. Clinical and Experimental Metastasis 2012 29 2 165 178 2-s2.0-84857182865 10.1007/s10585-011-9439-z
37. Tuszynski G. P., Cossu G., Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines. Cancer Research 1984 44 2 768 771 2-s2.0-0021355071 (Pubitemid 14184616)
38. Wu Y.-W., Chik C. L., Knazek R. A., An in vitro and in vivo study of antitumor effects of gossypol on human SW-13 adrenocortical carcinoma. Cancer Research 1989 49 14 3754 3758 2-s2.0-0024334136 (Pubitemid 19197392)
39. Badawy S. Z. A., Souid A.-K., Cuenca V., Montalto N., Shue F., Gossypol inhibits proliferation of endometrioma cells in culture. Asian Journal of Andrology 2007 9 3 388 393 2-s2.0-34347234208 10.1111/j.1745-7262.2007.00168.x (Pubitemid 47097296)
40. Ko C.-H., Shen S.-C., Yang L.-Y., Lin C.-W., Chen Y.-C., Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. International Journal of Cancer 2007 121 8 1670 1679 2-s2.0-34548680503 10.1002/ijc.22910 (Pubitemid 47417282)
41. Chien C.-C., Ko C.-H., Shen S.-C., Yang L.-Y., Chen Y.-C., The role of COX-2/PGE2 in gossypol-induced apoptosis of colorectal carcinoma cells. Journal of Cellular Physiology 2012 227 8 3128 3137 2-s2.0-84860464663 10.1002/jcp.23067
42. Hsiao W.-T., Tsai M.-D., Jow G.-M., Tien L.-T., Lee Y.J., Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells. Molecular Vision 2012 18 2033 2042
43. Wong F. Y., Liem N., Xie C., Yan F. L., Wong W. C., Wang L., Yong W. P., Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression. PLoS ONE 2012 7 12 e50786 10.1371/journal.pone.0050786
44. Blevins S., Siegel P. B., Blodgett D. J., Ehrich M., Saunders G. K., Lewis R. M., Effects of silymarin on gossypol toxicosis in divergent lines of chickens. Poultry Science 2010 89 9 1878 1886 2-s2.0-77958087283 10.3382/ps.2010-00768
45. Deoras D. P., Young-Curtis P., Dalvi R. R., Tippett F. E., Effect of gossypol on hepatic and serum γ -glutamyltransferase activity in rats. Veterinary Research Communications 1997 21 5 317 323 2-s2.0-0030750062 10.1023/A:1005856119553 (Pubitemid 27297078)
46. Fonseca N. B. S., Gadelha I. C. N., Oloris S. C. S., Soto-Blanco B., Effectiveness of albumin-conjugated gossypol as an immunogen to prevent gossypol-associated acute hepatotoxicity in rats. Food and Chemical Toxicology 2013 56 149 153 10.1016/j.fct.2013.02.010
47. El-Sharaky A. S., Newairy A. A., Elguindy N. M., Elwafa A. A., Spermatotoxicity, biochemical changes and histological alteration induced by gossypol in testicular and hepatic tissues of male rats. Food and Chemical Toxicology 2010 48 12 3354 3361 2-s2.0-78049434274 10.1016/j.fct.2010.09.004
48. Hahn D. W., Rusticus C., Probst A., Antifertility and endocrine activities of gossypol in rodents. Contraception 1981 24 1 97 105 2-s2.0-0019788274 (Pubitemid 12196551)
49. Heywood R., Lloyd G. K., Majeed S. K., Gopinath C., The toxicity of gossypol to the male rat. Toxicology 1986 40 3 279 284 2-s2.0-0022472809 (Pubitemid 16043803)
50. Gåfvels M., Wang J., Bergh A., Damber J. E., Selstam G., Toxic effects of the antifertility agent gossypol in male rats. Toxicology 1984 32 4 325 333 2-s2.0-0021189518 10.1016/0300-483X(84)90084-2 (Pubitemid 14043211)
51. Chenoweth P. J., Risco C. A., Larsen R. E., Velez J., Tran T., Chase C. C. Jr., Effects of dietary gossypol on aspects of semen quality, sperm morphology and sperm production in young Brahman bulls. Theriogenology 1994 42 1 1 13 2-s2.0-0002515675
52. Hassan M. E., Smith G. W., Ott R. S., Faulkner D. B., Firkins L. D., Ehrhart E. J., Schaeffer D. J., Reversibility of the reproductive toxicity of gossypol in peripubertal bulls. Theriogenology 2004 61 6 1171 1179 2-s2.0-1242310818 10.1016/j.theriogenology.2003.07.007 (Pubitemid 38231655)
53. Gu Y., Anderson N. O., Effects of gossypol on the estrous cycle and ovarian weight in the rat. Contraception 1985 32 5 491 496 2-s2.0-0022341981 (Pubitemid 16172127)
54. Lin Y. C., Fukaya T., Rikihisa Y., Walton A., Gossypol in female fertility control: ovum implantation and early pregnancy inhibited in rats. Life Sciences 1985 37 1 39 47 2-s2.0-0021869093 10.1016/0024-3205(85)90623-X (Pubitemid 15039758)
55. Lagerlöf R. K., Tone J. N., The effect of gossypol acetic acid on female reproduction. Drug and Chemical Toxicology 1985 8 6 469 482 2-s2.0-0022338037 (Pubitemid 16164342)
56. Gambill M. D., Humphrey W. D., Effects of diets containing gossypol on ovarian histology, function and fertility in prepubertal beef heifers. Theriogenology 1993 40 3 585 593 2-s2.0-38248999128
57. Randel R. D., Willard S. T., Wyse S. J., French L. N., Effects of diets containing free gossypol on follicular development, embryo recovery and corpus luteum function in brangus heifers treated with bFSH. Theriogenology 1996 45 5 911 922 2-s2.0-0006673950 (Pubitemid 126649724)
58. Arieli A., Whole cottonseed in dairy cattle feeding: a review. Animal Feed Science and Technology 1998 72 1-2 97 110 2-s2.0-0002329216 (Pubitemid 128414071)
59. Noftsger S. M., Hopkins B. A., Diaz D. E., Brownie C., Whitlow L. W., Effect of whole and expanded-expelled cottonseed on milk yield and blood gossypol. Journal of Dairy Science 2000 83 11 2539 2547 2-s2.0-0034327974
60. Shawrang P., Mansouri M. H., Sadeghi A. A., Ziaie F., Evaluation and comparison of gamma- and electron beam irradiation effects on total and free gossypol of cottonseed meal. Radiation Physics and Chemistry 2011 80 6 761 762 2-s2.0-79953061950 10.1016/j.radphyschem.2011.01.010
61. Ebrahimi-Mahmoudabad S. R., Taghinejad-Roudbaneh M., Investigation of electron beam irradiation effects on anti-nutritional factors, chemical composition and digestion kinetics of whole cottonseed, soybean and canola seeds. Radiation Physics and Chemistry 2011 80 12 1441 1447 2-s2.0-80052964620 10.1016/j.radphyschem.2011.08.003
62. Lim S.-J., Lee K.-J., A microbial fermentation of soybean and cottonseed meal increases antioxidant activity and gossypol detoxification in diets for nile tilapia, oreochromis niloticus. Journal of the World Aquaculture Society 2011 42 4 494 503 2-s2.0-79961073401 10.1111/j.1749-7345.2011.00491.x
63. Zhang W.-J., Xu Z.-R., Sun J.-Y., Yang X., Effect of selected fungi on the reduction of gossypol levels and nutritional value during solid substrate fermentation of cottonseed meal. Journal of Zhejiang University B: Science 2006 7 9 690 695 2-s2.0-33750591217 10.1631/jzus.2006.B0690
64. Zhang W.-J., Xu Z.-R., Zhao S.-H., Sun J.-Y., Yang X., Development of a microbial fermentation process for detoxification of gossypol in cottonseed meal. Animal Feed Science and Technology 2007 135 1-2 176 186 2-s2.0-34047245429 10.1016/j.anifeedsci.2006.06.003 (Pubitemid 46551515)
65. Weng X.-Y., Sun J.-Y., Kinetics of biodegradation of free gossypol by Candida tropicalis in solid-state fermentation. Biochemical Engineering Journal 2006 32 3 226 232 2-s2.0-33750980145 10.1016/j.bej.2006.10.007 (Pubitemid 44751586)
66. Zhang W.-J., Xu Z.-R., Zhao S.-H., Jiang J.-F., Wang Y.-B., Yan X.-H., Optimization of process parameters for reduction of gossypol levels in cottonseed meal by Candida tropicalis ZD-3 during solid substrate fermentation. Toxicon 2006 48 2 221 226 2-s2.0-33746237749 10.1016/j.toxicon.2006.05.003 (Pubitemid 44093682)
67. Sun Z.-T., Liu C., Du J.-H., Optimisation of fermentation medium for the detoxification of free gossypol in cottonseed powder by Geotrichum candidum G07 in solid-state fermentation with response surface methodology. Annals of Microbiology 2008 58 4 683 690 2-s2.0-58149517244
68. EL-Mokadem M. Y., Taha T. A., Samak M. A., Yassen A. M., Alleviation of reproductive toxicity of gossypol using selenium supplementation in rams. Journal of Animal Science 2012 90 9 3274 3285 10.2527/jas.2011-4545
69. Velasquez-Pereira J., Chenoweth P. J., McDowell L. R., Risco C. A., Staples C. A., Prichard D., Martin F. G., Calhoun M. C., Williams S. N., Wilkinson N. S., Reproductive effects of feeding gossypol and vitamin E to bulls. Journal of Animal Science 1998 76 11 2894 2904 2-s2.0-0032197279 (Pubitemid 128464897)
70. Velasquez-Pereira J., Aréchiga C. F., McDowell L. R., Hansen P. J., Chenoweth P. J., Calhoun M. C., Risco C. A., Batra T. R., Williams S. N., Wilkinson N. S., Effects of gossypol from cottonseed meal and dietary vitamin E on the reproductive characteristics of superovulated beef heifers. Journal of Animal Science 2002 80 9 2485 2492 2-s2.0-0036716554 (Pubitemid 41151697)
71. Haschek W. M., Beasley V. R., Buck W. B., Finnell J. H., Cottonseed meal (gossypol) toxicosis in a swine herd. Journal of the American Veterinary Medical Association 1989 195 5 613 615 2-s2.0-0024727613
72. Barraza M. L., Coppock C. E., Brooks K. N., Wilks D. L., Saunders R. G., Latimer G. W. Jr., Iron sulfate and feed pelleting to detoxify free gossypol in cottonseed diets for dairy cattle. Journal of Dairy Science 1991 74 10 3457 3467 2-s2.0-0026232819
73. Schneider I. C., Ames M. L., Rasmussen M. A., Reilly P. J., Fermentation of cottonseed and other feedstuffs in cattle rumen fluid. Journal of Agricultural and Food Chemistry 2002 50 8 2267 2273 2-s2.0-0037051503 10.1021/jf010783n (Pubitemid 34275296)
74. Lindsey T. O., Hawkins G. E., Guthrie L. D., Physiological responses of lactating cows to gossypol from cottonseed meal rations. Journal of Dairy Science 1980 63 4 562 573 2-s2.0-0019001278
75. Kim H. L., Calhoun M. C., Stipanovic R. D., Accumulation of gossypol enantiomers in ovine tissues. Comparative Biochemistry and Physiology B: Biochemistry and Molecular Biology 1996 113 2 417 420 2-s2.0-0029968601 10.1016/0305-0491(95)02061-6 (Pubitemid 26132672)
76. Abou-Donia M. B., Othman M. A., Obih P., Interspecies comparison of pharmacokinetic profile and bioavailability of (±)-gossypol in male Fischer-344 rats and male B6C3F mice. Toxicology 1989 55 1-2 37 51 2-s2.0-0024498589 (Pubitemid 19094977)
77. Chen Q. Q., Chen H., Lei H. P., Comparative study on the metabolism of optical gossypol in rats. Journal of Ethnopharmacology 1987 20 1 31 37 2-s2.0-0023188953
78. Eagle E., Effect of repeated doses of gossypol on the dog. Archives of Biochemistry 1950 26 1 68 71
79. Patton C. S., Legendre A. M., Gompf R. E., Walker M. A., Heart failure caused by gossypol poisoning in two dogs. Journal of the American Veterinary Medical Association 1985 187 6 625 627 2-s2.0-0021831628 (Pubitemid 15249467)
80. Kerr L. A., Gossypol toxicosis in cattle. Compendium on Continuing Education for the Practising Veterinarian 1989 11 9 1139 1146
81. Gadelha I. C. N., do Nascimento Rangel A. H., Silva A. R., Soto-Blanco B., Efeitos do gossipol na reprodução animal. Acta Veterinaria Brasilica 2011 5 2 129 135
82. Henry M. H., Pesti G. M., Brown T. P., Pathology and histopathology of gossypol toxicity in broiler chicks. Avian Diseases 2001 45 3 598 604 2-s2.0-0034802716 (Pubitemid 32901037)
83. West J. L., Lesions of gossypol poisoning in the dog. Journal of the American Veterinary Medical Association 1940 96 74 76
84. Uzal F. A., Puschner B., Tahara J. M., Nordhausen R. W., Gossypol toxicosis in a dog consequent to ingestion of cottonseed bedding. Journal of Veterinary Diagnostic Investigation 2005 17 6 626 629 2-s2.0-27944465678 (Pubitemid 41666920)
85. Morgan S., Stair E. L., Martin T., Edwards W. C., Morgan G. L., Clinical, clinicopathologic, pathologic, and toxicologic alterations associated with gossypol toxicosis in feeder lambs. American Journal of Veterinary Research 1988 49 4 493 499 2-s2.0-0023900237
86. East N. E., Anderson M., Lowenstine L. J., Apparent gossypol-induced toxicosis in adult dairy goats. Journal of the American Veterinary Medical Association 1994 204 4 642 643 2-s2.0-0028773089
87. Zhang W.-J., Xu Z.-R., Pan X.-L., Yan X.-H., Wang Y.-B., Advances in gossypol toxicity and processing effects of whole cottonseed in dairy cows feeding. Livestock Science 2007 111 1-2 1 9 2-s2.0-34547101946 10.1016/j.livsci.2007.03.006 (Pubitemid 47102740)
88. Willard S. T., Neuendorff D. A., Lewis A. W., Randel R. D., Effects of free gossypol in the diet of pregnant and postpartum Brahman cows on calf development and cow performance. Journal of Animal Science 1995 73 2 496 507 2-s2.0-0029242314
89. Rogers P. A. M., Henaghan T. P., Wheeler B., Gossypol poisoning in young calves. Irish Veterinary Journal 1975 29 1 9 13 2-s2.0-0016667865
90. Holmberg C. A., Weaver L. D., Gutterbock W. M., Genes J., Montgomery P., Pathological and toxicological studies of calves fed a high concentration cotton seed meal diet. Veterinary Pathology 1988 25 2 147 153 2-s2.0-0023850236 (Pubitemid 18084832)
91. Risco C. A., Holmberg C. A., Kutches A., Effect of graded concentrations of gossypol on calf performance: toxicological and pathological considerations. Journal of Dairy Science 1992 75 10 2787 2798 2-s2.0-0026941408
92. Zelski R. Z., Rothwell J. T., Moore R. E., Kennedy D. J., Gossypol toxicity in preruminant calves. Australian Veterinary Journal 1995 72 10 394 398 2-s2.0-0029383331
93. Fombad R. B., Bryant M. J., An evaluation of the use of cottonseed cake in the diet of growing pigs. Tropical Animal Health and Production 2004 36 3 295 305 2-s2.0-1642317123 10.1023/B:TROP.0000016828.48326.59 (Pubitemid 38377673)
94. Hudson L. M., Kerr L. A., Maslin W. R., Gossypol toxicosis in a herd of beef calves. Journal of the American Veterinary Medical Association 1988 192 9 1303 1305 2-s2.0-0024004115
95. Mena H., Santos J. E. P., Huber J. T., Tarazon M., Calhoun M. C., The effects of varying gossypol intake from whole cottonseed and cottonseed meal on lactation and blood parameters in lactating dairy cows. Journal of Dairy Science 2004 87 8 2506 2518 2-s2.0-4243069541 (Pubitemid 39103977)
96. Zbidah M., Lupescu A., Shaik N., Lang F., Gossypol-induced suicidal erythrocyte death. Toxicology 2012 302 2-3 101 105 10.1016/j.tox.2012.09.010
97. Tang F., Wong P. Y. D., Serum potassium and aldosterone levels in gossypol-treated rats. International Journal of Andrology 1984 7 2 149 153 2-s2.0-0021279907 (Pubitemid 14131816)
98. Rikihisa Y., Lin Y. C., Effect of gossypol on the thyroid in young rats. Journal of Comparative Pathology 1989 100 4 411 417 2-s2.0-0024373845 (Pubitemid 19254336)
99. Lin Y. C., Chitcharoenthum M., Rikihisa Y., Effect of gossypol on thyroid hormones in young female rats. Contraception 1990 41 4 431 440 2-s2.0-0025211801 10.1016/0010-7824(90)90042-T (Pubitemid 20134351)
100. Udoh P., Patil D. R., Deshpande M. K., Histopathological and biochemical effects of gossypol acetate on pituitary-gonadal axis of male albino rats. Contraception 1992 45 5 493 509 2-s2.0-0026549088 10.1016/0010-7824(92)90162-M
101. Janero D. R., Burghardt B., Protection of rat myocardial phospholipid against peroxidative injury through superoxide-(xanthine oxidase)-dependent, iron-promoted fenton chemistry by the male contraceptive gossypol. Biochemical Pharmacology 1988 37 17 3335 3342 2-s2.0-0023760940 10.1016/0006-2952(88)90647-8
102. Fornes M. W., Barbieri A. M., Burgos M. H., Sperm motility loss induced by gossypol: relation with OH. scavengers, motile stimulators and malondialdehyde production. Biochemical and Biophysical Research Communications 1993 195 3 1289 1293 2-s2.0-0027422086 10.1006/bbrc.1993.2183 (Pubitemid 23290293)
103. de Peyster A., Quintanilha A., Packer L., Smith M. T., Oxygen radical formation induced by gossypol in rat liver microsomes and human sperm. Biochemical and Biophysical Research Communications 1984 118 2 573 579 2-s2.0-0021351702 (Pubitemid 14194768)
104. Kovaci P., Mechanism of drug and toxic actions of gossypol: focus on reactive oxygen species and electron transfer. Current Medicinal Chemistry 2003 10 24 2711 2718 2-s2.0-0344824649 10.2174/0929867033456369 (Pubitemid 37456041)
105. Meksongsee L. A., Clawson A. J., Smith F. H., The in vivo effect of gossypol on cytochrome oxidase, succinoxidase, and succinic dehydrogenase in animal tissues. Journal of Agricultural and Food Chemistry 1970 18 5 917 920 2-s2.0-0014847661
106. Abou Donia M. B., Dieckert J. W., Gossypol: uncoupling of respiratory chain and oxidative phosphorylation. Life Sciences 1974 14 10 1955 1963 2-s2.0-0016213454
107. Tso W. W., Lee C. S., Gossypol uncoupling of respiratory chain and oxidative phosphorylation in ejaculated boar spermatozoa. Contraception 1982 25 6 649 655 2-s2.0-0019957079 (Pubitemid 12081766)
108. Huang W. M., Urthaler F., The direct negative inotropic effect of gossypol. Journal of Ethnopharmacology 1986 17 1 31 36 2-s2.0-0022999982 (Pubitemid 17185552)
109. Wang Y., Lei H.-P., Hepatotoxicity of gossypol in rats. Journal of Ethnopharmacology 1987 20 1 53 64 2-s2.0-0023179115
110. Manabe S., Nuber D. C., Lin Y. C., Zone-specific hepatotoxicity of gossypol in perfused rat liver. Toxicon 1991 29 6 787 790 2-s2.0-0025825635 10.1016/0041-0101(91)90071-X
111. Qian S. Z., Wang Z. G., Gossypol: a potential antifertility agent for males. Annual Review of Pharmacology and Toxicology 1984 24 329 360 2-s2.0-0021287511 (Pubitemid 14129539)
112. Yu Z.-H., Chan H. C., Gossypol as a male antifertility agent-why studies should have been continued. International Journal of Andrology 1998 21 1 2 7 2-s2.0-0031745521 10.1046/j.1365-2605.1998.00091.x (Pubitemid 28230973)
113. Coutinho E. M., Gossypol: a contraceptive for men. Contraception 2002 65 4 259 263 2-s2.0-0036098726 10.1016/S0010-7824(02)00294-9 (Pubitemid 34518604)
114. Dodou K., Investigations on gossypol: past and present developments. Expert Opinion on Investigational Drugs 2005 14 11 1419 1434 2-s2.0-27744431949 10.1517/13543784.14.11.1419 (Pubitemid 41601456)
115. Chang Q., Liu Z., Ma W.-Z., Hei C.-C., Shen X.-S., Qian X.-J., Xu Z.-L., Drug synergistic antifertility effect of combined administration of low-dose gossypol with steroid hormones in rats. Chinese Medical Journal 2011 124 11 1678 1682 2-s2.0-79957901365 10.3760/cma.j.issn.0366-6999.2011.11.014
116. Chongthammakun S., Ekavipat C., Sanitwongse B., Pavasuthipaisit K., Effects of gossypol on human and monkey sperm motility in vitro. Contraception 1986 34 3 323 331 2-s2.0-0023029290 (Pubitemid 17177024)
117. Hong C. Y., Huang J. J., Wu P., The inhibitory effect of gossypol on human sperm motility: relationship with time, temperature and concentration. Human Toxicology 1989 8 1 49 51 2-s2.0-0024577344 (Pubitemid 19091214)
118. Brocas C., Rivera R. M., Paula-Lopes F. F., McDowell L. R., Calhoun M. C., Staples C. R., Wilkinson N. S., Boning A. J., Chenoweth P. J., Hansen P. J., Deleterious actions of gossypol on bovine spermatozoa, oocytes, and embryos. Biology of Reproduction 1997 57 4 901 907 2-s2.0-15444359309 10.1095/biolreprod57.4.901 (Pubitemid 27407212)
119. Chenoweth P. J., Chase C. C. Jr., Risco C. A., Larsen R. E., Characterization of gossypol-induced sperm abnormalities in bulls. Theriogenology 2000 53 5 1193 1203 2-s2.0-0034654445 10.1016/S0093-691X(00) 00264-8 (Pubitemid 30252224)
120. Yuan Y. Y., Shi Q. X., Inhibition of hamster sperm acrosomal enzyme by gossypol is closely associated with the decrease in fertilization capacity. Contraception 2000 62 4 203 209 2-s2.0-0034538489 10.1016/S0010-7824(00)00161-X (Pubitemid 32008607)
121. Beaudoin A. R., A developmental toxicity evaluation of gossypol. Contraception 1988 37 2 197 219 2-s2.0-0023841815 (Pubitemid 18089593)
122. Nunes F. D. C. R., de Araujo D. A. F. V., Bezerra M. B., Soto-Blanco B., Effects of gossypol present in cottonseed cake on the spermatogenesis of goats. Journal of Animal and Veterinary Advances 2010 9 1 75 78 2-s2.0-77953772788 10.3923/javaa.2010.75.78
123. Guedes F. C. B., Soto-Blanco B., Sperm quality of sheep fed cottonseed cake. Acta Scientiae Veterinariae 2010 38 4 415 418 2-s2.0-79957996557
124. Ueno H., Sahni M. K., Segal S. J., Koide S. S., Interaction of gossypol with sperm macromolecules and enzymes. Contraception 1988 37 3 333 341 2-s2.0-0023876459 (Pubitemid 18091812)
125. Teng C. S., Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. Contraception 1997 55 1 41 46 2-s2.0-0031014127 10.1016/S0010-7824(96)00240-5 (Pubitemid 27036588)
126. Breitbart H., Rubinstein S., Nass-Arden L., Effect of gossypol-acetic acid on calcium transport and ATPase activity in plasma membranes from ram and bull spermatozoa. International Journal of Andrology 1984 7 5 439 447 2-s2.0-0021715329 (Pubitemid 15190585)
127. Breitbart H., Mayevsky A., Nass-Arden L., Molecular mechanisms of gossypol action on sperm motility. International Journal of Biochemistry 1989 21 10 1097 1102 2-s2.0-0024442747 (Pubitemid 19262746)
128. Hoffer A. P., Effects of gossypol on the seminiferous epithelium in the rat: a light and electron microscope study. Biology of Reproduction 1983 28 4 1007 1020 2-s2.0-0020579940 (Pubitemid 13061782)
129. Arshami J., Ruttle J. L., Effects of diets containing gossypol on spermatogenic tissues of young bulls. Theriogenology 1988 30 3 507 516 2-s2.0-38249028091
130. Romualdo G. S., Klinefelter G. R., de Grava Kempinas W., Postweaning exposure to gossypol results in epididymis-specific effects throughout puberty and adulthood in rats. Journal of Andrology 2002 23 2 220 228 2-s2.0-0036179758 (Pubitemid 34169279)
131. Zhang M., Yuan H., He Z., Yuan L., Yi J., Deng S., Zhu L., Guo C., Lu Y., Wu J., Wen L., Wei Q., Xue L., DNA damage and decrease of cellular oxidase activity in piglet sertoli cells exposed to gossypol. African Journal of Biotechnology 2011 10 14 2797 2802 2-s2.0-79954554834
132. Timurkaan N., Yilmaz F., Timurkaan S., Effects of cottonseed flour on immunohistochemical localization of androgen receptors (AR) in rat testes. Revue de Medecine Veterinaire 2011 162 1 13 17 2-s2.0-79953132271
133. Gray M. L., Greene L. W., Williams G. L., Effects of dietary gossypol consumption on metabolic homeostasis and reproductive endocrine function in beef heifers and cows. Journal of Animal Science 1993 71 11 3052 3059 2-s2.0-0027691826
134. Adeyemo G. O., Longe O. G., Adejumo D. O., The reproductive performance of breeder cocks fed cottonseed cake-based diets. International Journal of Poultry Science 2007 6 2 140 144 2-s2.0-34247375625 (Pubitemid 46640672)
135. Basini G., Bussolati S., Baioni L., Grasselli F., Gossypol, a polyphenolic aldehyde from cotton plant, interferes with swine granulosa cell function. Domestic Animal Endocrinology 2009 37 1 30 36 2-s2.0-67349120765 10.1016/j.domaniend.2009.01.005
136. Gu Y., Lin Y. C., Rikihisa Y., Inhibitory effect of gossypol on steroidogenic pathways in cultured bovine luteal cells. Biochemical and Biophysical Research Communications 1990 169 2 455 461 2-s2.0-0025309006 10.1016/0006-291X(90)90353-O (Pubitemid 20216130)
137. Lin Y. C., Coskun S., Sanbuissho A., Effects of gossypol on in vitro bovine oocyte maturation and steroidogenesis in bovine granulosa cells. Theriogenology 1994 41 8 1601 1611 2-s2.0-38149144760
138. Zirkle S. M., Lin Y. C., Gwazdauskas F. C., Canseco R. S., Effect of gossypol on bovine embryo development during the preimplantation period. Theriogenology 1988 30 3 575 582 2-s2.0-38249028324
139. Lin Y. C., Rajamahendran P., Rikihisa Y., Inhibition of rat embryo implantation in the gossypol-treated uterine horn. Theriogenology 1991 35 4 769 777 2-s2.0-44949276010
140. Hernández-Cerón J., Jousan F. D., Soto P., Hansen P. J., Timing of inhibitory actions of gossypol on cultured bovine embryos. Journal of Dairy Science 2005 88 3 922 928 2-s2.0-22144459461 (Pubitemid 41431291)
141. Villaseñor M., Coscioni A. C., Galvão K. N., Chebel R. C., Santos J. E. P., Gossypol disrupts embryo development in heifers. Journal of Dairy Science 2008 91 8 3015 3024 2-s2.0-49749147166 10.3168/jds.2007-0939
142. Lin Y. C., Sanbuissho A., Coskun S., Rikihisa Y., Inhibition of in vitro fertilization and early embryonic development in hamsters by gossypol. Life Sciences 1994 55 14 1139 1145 2-s2.0-0027981368 10.1016/0024-3205(94)00242-8 (Pubitemid 24278472)
143. Li Y. F., Booth G. M., Seegmiller R. E., Evidence for embryotoxicity of gossypol in mice and chicks with no evidence of mutagenic activity in the ames test. Reproductive Toxicology 1989 3 1 59 62 2-s2.0-0024773815
144. Sein G. M., The embryotoxic and immunodepressive effects of gossypol. American Journal of Chinese Medicine 1986 14 3-4 110 115 2-s2.0-0022986696
145. Morales H., Tilquin P., Rees J. F., Massip A., Dessy F., van Langendonckt A., Pyruvate prevents peroxide-induced injury of in vitro preimplantation bovine embryos. Molecular Reproduction and Development 1999 52 2 149 157 (Pubitemid 29013383)
146. Hervé J.-C., Pluciennik F., Bastide B., Cronier L., Verrecchia F.,
147. Yurtcu E., Ergun M. A., Menevse A., Apoptotic effect of gossypol on human lymphocytes. Cell Biology International 2003 27 9 791 794 2-s2.0-0042326480 10.1016/S1065-6995(03)00168-9 (Pubitemid 37101363)
148. Cui G.-H., Xu Z.-L., Yang Z.-J., Xu Y.-Y., Xue S.-P., A combined regimen of gossypol plus methyltestosterone and ethinylestradiol as a contraceptive induces germ cell apoptosis and expression of its related genes in rats. Contraception 2004 70 4 335 342 2-s2.0-4644316815 10.1016/j.contraception.2004. 02.020 (Pubitemid 39286770)
149. Ergun M. A., Konac E., Erbas D., Ekmekci A., Apoptosis and nitric oxide release induced by thalidomide, gossypol and dexamethasone in cultured human chronic myelogenous leukemic K-562 cells. Cell Biology International 2004 28 3 237 242 2-s2.0-1242338169 10.1016/j.cellbi.2003.12.005 (Pubitemid 38230235)
150. Moon D.-O., Kim M.-O., Lee J.-D., Kim G.-Y., Gossypol suppresses NF- B activity and NF- B-related gene expression in human leukemia U937 cells. Cancer Letters 2008 264 2 192 200 2-s2.0-42749083872 10.1016/j.canlet.2008.01.030
151. Cengiz E., Karaca B., Kucukzeybek Y., Gorumlu G., Gul M. K., Erten C., Atmaca H., Uzunoglu S., Karabulut B., Sanli U. A., Uslu R., Overcoming drug resistance in hormone-and drug-refractory prostate cancer cell line, PC-3 by docetaxel and gossypol combination. Molecular Biology Reports 2010 37 3 1269 1277 2-s2.0-77951902764 10.1007/s11033-009-9501-y
152. Moon D.-O., Choi Y. H., Moon S.-K., Kim W.-J., Kim G.-Y., Gossypol decreases tumor necrosis factor- α -induced intercellular adhesion molecule-1 expression via suppression of NF- B activity. Food and Chemical Toxicology 2011 49 4 999 1005 2-s2.0-79952445986 10.1016/j.fct.2011.01.006
153. 2+ regulation in human hepatoma cells. Chinese Journal of Physiology 2003 46 3 117 122 2-s2.0-0041879998 (Pubitemid 37098869)
154. Braga A. P., MacIel M. V., Guerra D. G. F., Maia I. S. A. S., Oloris S. C. S., Soto-Blanco B., Extruded-expelled cottonseed meal decreases lymphocyte counts in male sheep. Revue de Medecine Veterinaire 2012 163 3 147 152 2-s2.0-84860259447
155. Xu W.-B., Xu L.-H., Lu H.-S., Ou-Yang D.-Y., Shi H.-J., Di J.-F., He X.-H., The immunosuppressive effect of gossypol in mice is mediated by inhibition of lymphocyte proliferation and by induction of cell apoptosis. Acta Pharmacologica Sinica 2009 30 5 597 604 2-s2.0-66749177977 10.1038/aps.2009.35
156. Quintana P. J. E., de Peyster A., Klatzke S., Park H. J., Gossypol-induced DNA breaks in rat lymphocytes are secondary to cytotoxicity. Toxicology Letters 2000 117 1-2 85 94 2-s2.0-0034734830 10.1016/S0378-4274(00) 00244-7
157. Sijun D., Pawlak A., Poźniak B., Suszko A., Szczypka M., Hui Y., Obmińska-Mrukowicz B., Effects of gossypol acetic acid on cellular and humoral immune response in non-immunized and SRBC-immunized mice. Central-European Journal of Immunology 2012 37 1 11 19 2-s2.0-84860313203
158. Xu D., Cai W.-J., Zhu B.-H., Dong C.-J., Zheng Z.-C., Gao Z.-Q., Clinical safety of long-term administration of gossypol in 32 cases. Contraception 1988 37 2 129 135 2-s2.0-0023856354 (Pubitemid 18089585)
159. Nagalakshmi D., Sastry V. R. B., Agrawal D. K., Katiyar R. C., Haematological and immunological response in lambs fed on raw and variously processed cottonseed meal. Asian-Australasian Journal of Animal Sciences 2001 14 1 21 29 2-s2.0-0345774269 (Pubitemid 33659639)
160. Pattanaik A. K., Sastry V. R. B., Singh D. K., Goswami T. K., Mohanty D. N., Effect of gossypol from cottonseed meal diets on some clinico-biochemical parameters and humoral immune response of crossbred calves fed barley or sorghum. Asian-Australasian Journal of Animal Sciences 2003 16 9 1291 1296 2-s2.0-0141590363 (Pubitemid 37171789)
161. Ohuchi K., Watanabe M., Hirasawa N., Tsurufuji S., Ozeki T., Fujiki H., Inhibition by gossypol of tumor promoter-induced arachidonic acid metabolism in rat peritoneal macrophages. Biochimica et Biophysica Acta: Molecular Cell Research 1988 971 1 85 91 2-s2.0-0023730738
162. Barros M. M., Lim C., Klesius P. H., Effect of soybean meal replacement by cottonseed meal and iron supplementation on growth, immune response and resistance of channel catfish (Ictalurus puctatus) to Edwardsiella ictaluri challenge. Aquaculture 2002 207 3-4 263 279 2-s2.0-0037165970 10.1016/S0044-8486(01)00740-2 (Pubitemid 34548664)
163. Yildirim M., Lim C., Wan P. J., Klesius P. H., Growth performance and immune response of channel catfish (Ictalurus puctatus) fed diets containing graded levels of gossypol-acetic acid. Aquaculture 2003 219 1-4 751 768 2-s2.0-0037413995 10.1016/S0044-8486(03)00062-0 (Pubitemid 36345546)
164. Fisher G. S., Frank A. W., Cherry J. P., Total gossypol content of glandless cottonseed. Journal of Agricultural and Food Chemistry 1988 36 1 42 44 2-s2.0-0011257824
165. Broderick G. A., Craig W. M., Effect of heat treatment on ruminal degradation and escape, and intestinal digestibility of cottonseed meal protein. Journal of Nutrition 1980 110 12 2381 2389 2-s2.0-0019126413 (Pubitemid 11169756)
166. Henry M. H., Pesti G. M., Bakalli R., Lee J., Toledo R. T., Eitenmiller R. R., Phillips R. D., The performance of broiler chicks fed diets containing extruded cottonseed meal supplemented with lysine. Poultry Science 2001 80 6 762 768 2-s2.0-0035380027 (Pubitemid 33659846)
167. Jaddou H., Al Hakim M., Al Adamy L. Z., Mhaisen M. T., Effect of gamma-radiation on gossypol in cottonseed meal. Journal of Food Science 1983 48 3 988 989 2-s2.0-0021038473 (Pubitemid 14244453)
168. Jo C., Yook H. S., Lee M. S., Kim J. H., Song H. P., Kwon J. S., Byun M. W., Irradiation effects on embryotoxicity and oxidative properties of gossypol dissolved in methanol. Food and Chemical Toxicology 2003 41 10 1329 1336 2-s2.0-0141655190 10.1016/S0278-6915(03)00125-X (Pubitemid 37289181)
169. Smalley S. A., Bicknell E. J., Gossypol toxicity in dairy cattle. Compendium on Continuing Education for the Practising Veterinarian 1982 4 9 S378 S381
170. Yang X., Sun J.-Y., Guo J.-L., Weng X.-Y., Identification and proteomic analysis of a novel gossypol-degrading fungal strain. Journal of the Science of Food and Agriculture 2012 92 4 943 951 2-s2.0-84856678754 10.1002/jsfa.4675
171. Sun H., Tang J. W., Fang C. L., Yao X. H., Wu Y. F., Wang X., Feng J., Molecular analysis of intestinal bacterial microbiota of broiler chickens fed diets containing fermented cottonseed meal. Poultry Science 2013 92 2 392 401 10.3382/ps.2012-02533.