A combined regimen of gossypol plus methyltestosterone and ethinylestradiol as a contraceptive induces germ cell apoptosis and expression of its related genes in rats

Contraception

Volumn 70, Issue 4, 2004, Pages 335-342

  Cui, Guang Hui ^a   Xu, Zeng Lu ^a   Yang, Zhan Jun ^a   Xu, Yuan Yuan ^a   Xue, She Pu ^a  

^a Department of Pharmacology   (China)

Author keywords

Apoptosis; Germ cell; Gossypol; Hormones; Rat testes

Indexed keywords

CASPASE 3; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; ETHINYLESTRADIOL; FAS ANTIGEN; GOSSYPOL; MESSENGER RNA; METHYLTESTOSTERONE; PROTEIN BAX;

AGAR GEL ELECTROPHORESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL TYPE; CONTRACEPTION; CONTROLLED STUDY; DOSE RESPONSE; GENE CONTROL; GENE EXPRESSION; GERM CELL; IN SITU HYBRIDIZATION; MALE; MOLECULAR WEIGHT; NICK END LABELING; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CONTRACEPTIVE AGENTS, MALE; DNA FRAGMENTATION; ETHINYL ESTRADIOL; GOSSYPOL; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; MALE; METHYLTESTOSTERONE; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPERMATIDS; SPERMATOCYTES; SPERMATOZOA;

EID: 4644316815     PISSN: 00107824     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.contraception.2004.02.020     Document Type: Article

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