Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent- and independent-signaling

Clinical and Experimental Metastasis

Volumn 29, Issue 2, 2012, Pages 165-178

  Jiang, Jiahua ^a   Slivova, Veronika ^a   Jedinak, Andrej ^a   Sliva, Daniel ^a,b  

^a METHODIST RESEARCH INSTITUTE   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Angiogenesis; AP 1; Cell cycle; Gossypol; Invasion; Metastasis; Migration; NF B

Indexed keywords

CHEMOKINE RECEPTOR CCR4; GOSSYPOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR AP 1; UROKINASE; VASCULOTROPIN;

ADHESION; ANGIOGENESIS; ARTICLE; CANCER GROWTH; CANCER INVASION; CELL CYCLE REGULATION; CELL MIGRATION; CONTROLLED STUDY; DATA ANALYSIS; ENZYME INHIBITION; ENZYME REPRESSION; HUMAN; HUMAN CELL; IC 50; MALE; PROSTATE CANCER; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DIVISION; DRUG EFFECT; GEL MOBILITY SHIFT ASSAY; IMMUNOHISTOCHEMISTRY; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PROSTATE TUMOR; TUMOR CELL LINE; VASCULARIZATION;

CELL DIVISION; CELL LINE, TUMOR; ELECTROPHORETIC MOBILITY SHIFT ASSAY; G0 PHASE; G1 PHASE; GOSSYPOL; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; NF-KAPPA B; PROSTATIC NEOPLASMS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 84857182865     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-011-9439-z     Document Type: Article

References (49)

1. A Jemal R Siegel J Xu, et al. 2010 Cancer statistics, 2010 CA Cancer J Clin 60 277 300 20610543 10.3322/caac.20073
2. JT Isaacs 1993 Prostatic cancer: an age-old problem Adv Exp Med Biol 330 167 184 8368132 1:STN:280:DyaK3sznslGlsQ%3D%3D 10.1007/978-1-4615-2926-2-13 (Pubitemid 23203000)
3. C Nessler-Menardi I Jotova Z Culig, et al. 2000 Expression of androgen receptor coregulatory proteins in prostate cancer and stromal-cell culture models Prostate 45 124 131 11027411 1:CAS:528:DC%2BD3cXnsFGisrs%3D 10.1002/1097-0045(20001001)45:2<124::AID-PROS6>3.0.CO;2-7
4. JT Price EW Thompson 2002 Mechanisms of tumour invasion and metastasis: emerging targets for therapy Expert Opin Ther Targets 6 217 233 12223082 1:CAS:528:DC%2BD38Xjs1KhtLc%3D 10.1517/14728222.6.2.217 (Pubitemid 34477462)
5. D Sliva 2004 Signaling pathways responsible for cancer cell invasion as targets for cancer therapy Curr Cancer Drug Targets 4 327 336 15180498 1:CAS:528:DC%2BD2cXkvFyjsrY%3D 10.2174/1568009043332961 (Pubitemid 38797244)
6. V Slivova G Zaloga SJ DeMichele, et al. 2005 Green tea polyphenols modulate secretion of urokinase plasminogen activator (uPA) and inhibit invasive behavior of breast cancer cells Nutr Cancer 52 66 73 16091006 1:CAS:528:DC%2BD2MXhtVemsbbK 10.1207/s15327914nc5201-9 (Pubitemid 41232651)
7. FP Lloyd Jr V Slivova T Valachovicova, et al. 2003 Aspirin inhibits highly invasive prostate cancer cells Int J Oncol 23 1277 1283 14532966 1:CAS:528:DC%2BD3sXptFCkur0%3D
8. H Allgayer 2006 Molecular regulation of an invasion-related molecule-options for tumour staging and clinical strategies Eur J Cancer 42 811 819 16617013 1:CAS:528:DC%2BD28XksVOitLo%3D 10.1016/j.ejca.2006.01.018
9. D Sliva C Labarrere V Slivova, et al. 2002 Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells Biochem Biophys Res Commun 298 603 612 12408995 1:CAS:528:DC%2BD38XotFSns7Y%3D 10.1016/S0006- 291X(02)02496-8 (Pubitemid 35333701)
10. BY Bao SD Yeh YF Lee 2006 1alpha, 25-dihydroxyvitamin D3 inhibits prostate cancer cell invasion via modulation of selective proteases Carcinogenesis 27 32 42 15987715 1:CAS:528:DC%2BD2MXhtlCmsbjE 10.1093/carcin/bgi170 (Pubitemid 43025242)
11. J Edwards NS Krishna R Mukherjee, et al. 2004 The role of c-Jun and c-Fos expression in androgen-independent prostate cancer J Pathol 204 153 158 15378488 1:CAS:528:DC%2BD2cXps1Kisb8%3D 10.1002/path.1605 (Pubitemid 39335288)
12. J Suh AB Rabson 2004 NF-kappaB activation in human prostate cancer: important mediator or epiphenomenon? J Cell Biochem 91 100 117 14689584 1:CAS:528:DC%2BD2cXlvV2gtA%3D%3D 10.1002/jcb.10729
13. R Eferl EF Wagner 2003 AP-1: a double-edged sword in tumorigenesis Nat Rev Cancer 3 859 868 14668816 1:CAS:528:DC%2BD3sXptFKlsbg%3D 10.1038/nrc1209 (Pubitemid 37383716)
14. JK Kundu YK Shin YJ Surh 2006 Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-kappaB and AP-1 as prime targets Biochem Pharmacol 72 1506 1515 16999939 1:CAS:528:DC%2BD28XhtFOjtrfL 10.1016/j.bcp.2006.08.005 (Pubitemid 44666749)
15. E Looby MM Abdel-Latif V Athie-Morales, et al. 2009 Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells BMC Cancer 9 190 19534809 10.1186/1471-2407-9-190
16. G Stanley K Harvey V Slivova, et al. 2005 Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-beta1 from prostate cancer cells Biochem Biophys Res Commun 330 46 52 15781230 1:CAS:528:DC%2BD2MXisVCnu7c%3D 10.1016/j.bbrc.2005.02.116 (Pubitemid 40394934)
17. D Sliva D English D Lyons, et al. 2002 Protein kinase C induces motility of breast cancers by upregulating secretion of urokinase-type plasminogen activator through activation of AP-1 and NF-kappaB Biochem Biophys Res Commun 290 552 557 11779207 1:CAS:528:DC%2BD38XhsFCluw%3D%3D 10.1006/bbrc.2001.6225 (Pubitemid 34694537)
18. J Jiang B Grieb A Thyagarajan, et al. 2008 Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling Int J Mol Med 21 577 584 18425349 1:CAS:528: DC%2BD1cXmt1amtL4%3D
19. YC Lin M Chitcharoenthum Y Rikihisa 1987 Effect of gossypol on spermatozoal lactate dehydrogenase-X (LDH-X) in male rats Contraception 36 581 592 3447817 1:CAS:528:DyaL1cXovVaisw%3D%3D 10.1016/0010-7824(87)90010-2 (Pubitemid 18046693)
20. Y Gu PK Li YC Lin, et al. 1991 Gossypolone suppresses progesterone synthesis in bovine luteal cells J Steroid Biochem Mol Biol 38 709 715 2064986 1:CAS:528:DyaK3MXlt1OnsLw%3D 10.1016/0960-0760(91)90082-G
21. CJ Chang PK Ghosh YF Hu, et al. 1993 Antiproliferative and antimetastatic effects of gossypol on Dunning prostate cell-bearing Copenhagen rats Res Commun Chem Pathol Pharmacol 79 293 312 8480076 1:CAS:528:DyaK3sXit1Gisbg%3D (Pubitemid 23095803)
22. J Jiang Y Sugimoto S Liu, et al. 2004 The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway Anticancer Res 24 91 100 15015581 1:CAS:528:DC%2BD2cXisFGntbk%3D (Pubitemid 38279693)
23. F Shidaifat H Canatan SK Kulp, et al. 1996 Inhibition of human prostate cancer cells growth by gossypol is associated with stimulation of transforming growth factor-beta Cancer Lett 107 37 44 8913264 1:CAS:528:DyaK28Xnt1Sksbk%3D 10.1016/0304-3835(96)04340-6 (Pubitemid 26370855)
24. C Van Poznak AD Seidman MM Reidenberg, et al. 2001 Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial Breast Cancer Res Treat 66 239 248 11510695 10.1023/A: 1010686204736 (Pubitemid 32675026)
25. M Zhang H Liu Z Tian, et al. 2007 Gossypol induces apoptosis in human PC-3 prostate cancer cells by modulating caspase-dependent and caspase-independent cell death pathways Life Sci 80 767 774 17156797 1:CAS:528:DC%2BD2sXntl2isw%3D%3D 10.1016/j.lfs.2006.11.004 (Pubitemid 46108000)
26. DO Moon MO Kim JD Lee, et al. 2008 Gossypol suppresses NF-kappaB activity and NF-kappaB-related gene expression in human leukemia U937 cells Cancer Lett 264 192 200 18314260 1:CAS:528:DC%2BD1cXlslSisb0%3D 10.1016/j.canlet.2008.01.030
27. YW Huang LS Wang MK Dowd, et al. 2009 (-)-Gossypol reduces invasiveness in metastatic prostate cancer cells Anticancer Res 29 2179 2188 19528479 1:CAS:528:DC%2BD1MXos1WmsL4%3D
28. A Jedinak D Sliva 2008 Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway Int J Oncol 33 1307 1313 19020765
29. J Jiang V Slivova D Sliva 2006 Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappaB signaling Int J Oncol 29 695 703 16865287 1:CAS:528: DC%2BD28XptVamur4%3D
30. YA Elsayed EA Sausville 2001 Selected novel anticancer treatments targeting cell signaling proteins Oncologist 6 517 537 11743214 1:CAS:528:DC%2BD38XktF2ktg%3D%3D 10.1634/theoncologist.6-6-517 (Pubitemid 33152097)
31. J Jiang SK Kulp Y Sugimoto, et al. 2000 The effects of gossypol on the invasiveness of MAT-LyLu cells and MAT-LyLu cells from the metastasized lungs of MAT-LyLu-bearing Copenhagen rats Anticancer Res 20 4591 4597 11205308 1:CAS:528:DC%2BD3MXhtVejtrs%3D (Pubitemid 32141824)
32. CL Gladson DR Welch 2008 New insights into the role of CXCR4 in prostate cancer metastasis Cancer Biol Ther 7 1849 1851 18981717 1:CAS:528: DC%2BD1MXhvVGnsro%3D 10.4161/cbt.7.11.7218
33. JM Di J Zhou XL Zhou, et al. 2009 Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-C and lymph node metastases in human prostate cancer Arch Med Res 40 268 275 19608016 1:CAS:528: DC%2BD1MXoslaqur0%3D 10.1016/j.arcmed.2009.03.002
34. LE Littlepage MD Sternlicht N Rougier, et al. 2010 Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression Cancer Res 70 2224 2234 20215503 1:CAS:528:DC%2BC3cXjtFygt74%3D 10.1158/0008-5472.CAN-09-3515
35. LM Ellis DJ Hicklin 2008 VEGF-targeted therapy: mechanisms of anti-tumour activity Nat Rev Cancer 8 579 591 18596824 1:CAS:528:DC%2BD1cXovV2lsro%3D 10.1038/nrc2403
36. K Milde-Langosch 2005 The Fos family of transcription factors and their role in tumourigenesis Eur J Cancer 41 2449 2461 16199154 1:CAS:528: DC%2BD2MXhtFyks73I 10.1016/j.ejca.2005.08.008 (Pubitemid 41540622)
37. JK Kundu YJ Surh 2004 Molecular basis of chemoprevention by resveratrol NF-kappaB and AP-1 as potential targets Mutat Res 555 65 80 15476852 1:CAS:528:DC%2BD2cXot12hu7c%3D 10.1016/j.mrfmmm.2004.05.019 (Pubitemid 39345398)
38. P Kukreja AB Abdel-Mageed D Mondal, et al. 2005 Up-regulation of CXCR4 expression in PC-3 cells by stromal-derived factor-1alpha (CXCL12) increases endothelial adhesion and transendothelial migration: role of MEK/ERK signaling pathway-dependent NF-kappaB activation Cancer Res 65 9891 9898 16267013 1:CAS:528:DC%2BD2MXhtFKktLrF 10.1158/0008-5472.CAN-05-1293 (Pubitemid 41541469)
39. LF Zerbini Y Wang JY Cho, et al. 2003 Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer Cancer Res 63 2206 2215 12727841 1:CAS:528:DC%2BD3sXjtlGmt7w%3D (Pubitemid 36538628)
40. Sliva DS (2007) Regulation of NF-kB function. In: Srivastava R (ed) Apoptosis, cell signaling, and human diseases: molecular mechanisms, vol 1. Humana Press, Inc., Totowa, p 239
41. M Branca C Giorgi D Santini, et al. 2005 Survivin as a marker of cervical intraepithelial neoplasia and high-risk human papillomavirus and a predictor of virus clearance and prognosis in cervical cancer Am J Clin Pathol 124 113 121 15923164 1:CAS:528:DC%2BD2MXmvVGntrs%3D 10.1309/L8BWF431WU9AC8FJ (Pubitemid 40944383)
42. KW Rahman Y Li Z Wang, et al. 2006 Gene expression profiling revealed survivin as a target of 3,3′-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells Cancer Res 66 4952 4960 16651453 1:CAS:528:DC%2BD28XjvF2ktLc%3D 10.1158/0008-5472.CAN-05-3918
43. R Kannangai J Wang QZ Liu, et al. 2005 Survivin overexpression in hepatocellular carcinoma is associated with p53 dysregulation Int J Gastrointest Cancer 35 53 60 15722574 1:CAS:528:DC%2BD2MXivFKhurw%3D 10.1385/IJGC:35:1:053 (Pubitemid 40458580)
44. Z Shi YJ Liang ZS Chen, et al. 2007 Overexpression of Survivin and XIAP in MDR cancer cells unrelated to P-glycoprotein Oncol Rep 17 969 976 17342344 1:CAS:528:DC%2BD2sXkt1Wnu7Y%3D
45. SR Volate BT Kawasaki EM Hurt, et al. 2010 Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells Mol Cancer Ther 9 461 470 20124455 1:CAS:528:DC%2BC3cXhsleku7c%3D 10.1158/1535-7163.MCT-09-0507
46. JL Li AL Harris 2009 Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications Front Biosci 14 3094 3110 19273260 1:CAS:528:DC%2BD1MXltlWnsbk%3D 10.2741/3438
47. L Xu D Yang S Wang, et al. 2005 (-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer Mol Cancer Ther 4 197 205 15713891 1:CAS:528:DC%2BD2MXhtleku70%3D 10.4161/cbt.4.2.1441 (Pubitemid 40340199)
48. XQ Zhang XF Huang SJ Mu, et al. 2010 Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using (-)-gossypol Asian J Androl 12 390 399 20081872 1:CAS:528:DC%2BC3cXlsFSitbw%3D 10.1038/aja.2009.87
49. H Kawakami M Tomita T Matsuda, et al. 2005 Transcriptional activation of survivin through the NF-kappaB pathway by human T-cell leukemia virus type I tax Int J Cancer 115 967 974 15729715 1:CAS:528:DC%2BD2MXltlWrsb8%3D 10.1002/ijc.20954 (Pubitemid 40791839)