Apoptosis and nitric oxide release induced by thalidomide, gossypol and dexamethasone in cultured human chronic myelogenous leukemic K-562 cells

Cell Biology International

Volumn 28, Issue 3, 2004, Pages 237-242

  Ergun, Mehmet Ali ^a   Konac, Ece ^a   Erbas, Deniz ^a   Ekmekci, Abdullah ^a  

^a GAZI UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Dexamethasone; Gossypol; K 562; Nitric oxide; Thalidomide

Indexed keywords

DEXAMETHASONE; GOSSYPOL; NITRIC OXIDE; THALIDOMIDE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL STRAIN K 562; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; HUMAN; HUMAN CELL; LEUKEMIA CELL; MYELOID LEUKEMIA;

EID: 1242338169     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2003.12.005     Document Type: Article

References (33)

1. Balci A., Sahin F.I., Ekmekci A. Gossypol induced apoptosis in the human promyelocytic leukemia cell line HL 60. Tohoku J Exp Med. 189:1999;51-57.
2. Bauer K.S., Dixon S.C., Figg W.D. Inhibition of angiogenesis by thalidomide requires metabolic activation, which is species- dependent. Biochem Pharmacol. 55:1998;1827-1834.
3. Bröker L.E., Giaccone G. The role of new agents in the treatment of non-small cell lung cancer. Eur J Cancer. 38:2002;2347-2361.
4. Clarke A.R., Purdie C.A., Harrison D.J., Morris R.G., Bird C.C., Hooper M.L., et al. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature. 362:1993;849-852.
5. Dao V.T., Baspard C., Mayer M., Werner G.H., Nguyen S.N., Michelot R.J. Synthesis and cytotoxicity of gossypol related compounds. Eur J Med Chem. 35:2000;805-813.
6. Davies F.E., Raje N., Hideshima T., Lentzsch S., Young G., Tai Y.T., et al. Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood. 98:2001;210-216.
7. Dreher D., Junod A.F. Role of oxygen free radicals in cancer development. Eur J Cancer. 32A:1996;30-38.
8. Durrieu F., Belloc F., Lacoste L., Dumain P., Chabrol J., Dachary-Prigent J., et al. Caspase activation is an early event in anthracycline-induced apoptosis and allows detection of apoptotic cells before they are ingested by phagocytosis. Exp Cell Res. 240:1998;165-175.
9. Eisen T., Boshoff C., Mak I., Sapunar F., Vaughan M.M., Pyle L., et al. Continuous low dose thalidomide: phase II study in advanced melanoma, renal cell, ovarian and breast cancer. Br J Cancer. 82:2000;812-817.
10. Gallily R., Kipper-Galperin M., Brenner T. Mycoplasma fermentans-induced inflammatory response of astrocytes: Selective modulation by aminoguanidine, thalidomide, pentoxifylline and IL-10. Inflammation. 23:1999;495-505.
11. Gilbert N.E., O'Reilly J.E., Chang C.J., Lin Y.C. Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. Life Sci. 57:1995;61-67.
12. Green L.C.D., Wagner D.D.A., Glogowski J., Skepper P.L., Wishnok J.S., Tannenbaum S.R. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Ann Biochem. 126:1982;131-136.
13. Halliwel B.A. Superway to kill cancer cells? Nat Med. 6:2000;1105-1106.
14. Hansen J.M., Carney E.W., Harris C. Differential alteration by thalidomide of the glutathione content of rat vs. rabbit conceptuses in vitro. Reprod Toxicol. 13:1999;547-554.
15. Hideshima T., Chauhan D., Shima Y., Raje N., Davies F.E., Tai Y.T., et al. Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy. Blood. 96:2000;2943-2950.
16. Ho C.Y., Wong C.K., Li E.K., Lam W.K. Effects of dexamethasone on the expression of Fas molecules and apoptosis of lymphocytes in patients with systemic lupus erythematosus. Immunol Invest. 30:2001;231-243.
17. ++-dependent protein kinase from pig testis. Biochim Biophys Acta. 839:1985;276-280.
18. Konac E., Ergun M.A., Sahin F.I., Ekmekci A. Detection of p53 deletions using FISH values in the HL-60, Daudi, Raji and K-562 cell-lines. Exp Oncol. 25:2003;33-35.
19. Law J.C., Ritke M.I.L., Yalowich J.C., Leder G.H., Ferrel R.E. Mutational inactivation of the p53 gene in the human erythroid leukemic K-562 cell line. Leuk Res. 12:1993;1045-1050.
20. Li Y., Yan Y., Brauber A., Tullus R. Meconium induces expression of inducible NO synthase and activation of NF-B in rat alveolar macrophages. Pediatr Res. 49:2001;820-825.
21. Lowe S.W., Schmitt E.M., Smith S.W., Osborne B.A., Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature. 362:1993;847-849.
22. Parman T., Wiley M.J., Wells P.G. Free-radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity. Nat Med. 5:1999;582-585.
23. Quintana P.J.E., Pesyter A., Klatzke S., Park H.J. Gossypol-induced DNA breaks in rat lymphocytes are secondary to cytotoxicity. Toxicol Lett. 117:2000;85-94.
24. Renner K., Amberger A., Konwalinka G., Kofler R., Gnaiger E. Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells. Biochim Biophys Acta. 1642:2003;115-123.
25. Richardson P., Hideshima T., Anderson K. Thalidomide: emerging role in cancer medicine. Annu Rev Med. 53:2002;629-657.
26. Ritke M.K., Rusnak J.M., Lazo J.S., Allan W.P., Dive C., Heer S. Differential induction of etoposide-mediated apoptosis in human leukemia HL-60 and K-562 cells. Mol Pharmacol. 46:1994;605-611.
27. Secchiero P., Gonelli A., Celeghini C., Mirandola P., Guidotti L., Visani G., et al. Activation of the nitric oxide synthase pathway represents a key component of tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity on hematologic malignancies. Blood. 98:2001;2220-2228.
28. Ushmorov A., Ratter F., Lehmann V., Droge W., Schirrmacher V., Umansky V. Nitric-oxide-induced apoptosis in human leukemic lines requires mitochondrial lipid degradation and cytochrome C release. Blood. 93:1999;2342-2352.
29. Vescovo G., Ravara B., Angelini A., Sandri M., Carraro U., Ceconi C., et al. Effect of thalidomide on the skeletal muscle in experimental heart failure. Eur J Heart Fail. 4:2002;455-460.
30. Wang X., Wang J., Wang S.C.H., Chow L.S.N., Nicholls J.M., Wong Y.C., et al. Cytotoxic effect of gossypol on colon carcinoma cells. Life Sci. 67:2000;2663-2671.
31. Yata K., Otsuki T., Kurebayashi J., Uno M., Fujii T., Yawata Y., et al. Expression of angiogenic factors including VEGFs and the effects of hypoxia and thalidomide on human myeloma cells. Int J Oncol. 22:2003;165-173.
32. Zhang M., Liu H., Guo R., Ling Y., Wu X., Li B., et al. Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochem Pharmacol. 66:2003;93-103.
33. Zhang W.Y., Gotoh T., Oyadomaria S., Mori M. Coinduction of inducible nitric oxide synthase and arginine recycling enzymes in cytokine-stimulated PC12 cells and high output production of nitric oxide. Mol Brain Res. 83:2000;1-8.