Effects of gossypol acetic acid on cellular and humoral immune response in non-immunized and SRBC-immunized mice

Central-European Journal of Immunology

Volumn 37, Issue 1, 2012, Pages 11-19

  Sijun, Deng ^a   Pawlak, Aleksandra ^b   Poźniak, Błazej ^b   Suszko, Agnieszka ^b   Szczypka, Marianna ^b   Hui, Yuan ^a   Obmińska Mrukowicz, Bozena ^b  

^a HUNAN AGRICULTURAL UNIVERSITY   (China)

^b WROCLAW UNIVERSITY OF ENVIRONMENTAL AND LIFE SCIENCES   (Poland)

Author keywords

Cellular response; Gossypol acetic acid; Humoral response; Lymphatic organs; Mice

Indexed keywords

GOSSYPOL ACETIC ACID; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL POPULATION; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; HUMORAL IMMUNITY; IN VITRO STUDY; LYMPHOCYTE COUNT; MACROPHAGE; MALE; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PLAQUE FORMING CELL; SHEEP; SPLEEN CELL; THYMOCYTE;

EID: 84860313203     PISSN: 14263912     EISSN: 16444124     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Hou HL, Luo YL (2005): Toxicity of gossypol. Shui Li Yu Ye 25: 100-102.
2. Kenar AJ (2006): Reaction chemistry of gossypol and its derivatives. J Am Oil Chem Soc 83: 269-302.
3. Rikihisa Y, Lin YC, Garber PL, Gu Y (1990): Taenia taeniaeformis: inactivation of metacestodes by gossypol in vitro. Exp Parasitol 71: 135-145. (Pubitemid 20279484)
4. Yildirim-Aksoy M, Lim C, Wan P, Klessius PH (2004): Effect of natural free gossypol and gossypol-acetic acid on growth performance and resistance of channel catfish (Ictalurus punctatus) to Edwardsiella ictaluri challenge. Aquacult Nutr 10: 153-165. (Pubitemid 38751596)
5. Dodou K, Anderson RJ, Small DA, Groundwater PW (2005): Investigations on gossypol: past and present developments. Expert Opin Investig Drugs 14: 1419-1434. (Pubitemid 41601456)
6. Dao VT, Gaspard C, Mayer M, et al. (2000): Synthesis and cytotoxicity of gossypol related compounds. Eur J Med Chem 35: 805-813.
7. Xu L, Yang D, Wang S, et al. (2005): (-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer. Mol Cancer Ther 4: 197-205. (Pubitemid 40340199)
8. Jarvis WD, Turner AJ, Povirk LF, et al. (1994): Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res 54: 1707-1714. (Pubitemid 24116174)
9. Yunis JJ, Frizzera G, Oken MM, et al. (1987): Multiple recurrent genomic defects in follicular lymphoma. A possible model for cancer. N Engl J Med 316: 79-84. (Pubitemid 17052742)
10. Katayama N, Nishikawa M, Minami N, Shirakawa S (1989): Putative involvement of protein kinase C in proliferation of human myeloid progenitor cells. Blood 73: 123-130. (Pubitemid 19040965)
11. Hass R, Pfannkuche HJ, Kharbanda S, et al. (1991): Protein kinase C activation and protooncogene expression in differentiation/retrodifferentiation of human U-937 leukemia cells. Cell Growth Differ 2: 541-548.
12. He XH, Zeng YY, Xu LH, et al. (2002): Influences of protein kinase C inhibitors on the expression of IL-2 and IFN-γ by human T-lymphocytes. Chin J Pathophysiol 18: 522-525.
13. Hu CY, Jiang CH (1997): The biological activities and mechanisms of gossypol. Foreign Medical Sciences (Family Planning/ Reproductive Health Fascicle) 16: 68-72.
14. Huang MM, Shao XX, Xiong ZH, et al. (1981): The experimental research of taurine sodium gossypol immunosuppression. Acta Med Univ Sci Technol Huazhong 10: 77.
15. Mishell RI, Dutton RW (1967): Immunization of dissociated spleen cell cultures from normal mice. J Exp Med 126: 423-442.
16. Adler FL (1965) : Studies on mouse antibodies. II. Mercaptoethanol- sensitive 7 S antibodies in mouse antisera to protein antigens. J Immunol 95: 39-47.
17. Liang L, Wang SM, Hu XG, et al. (2008): Effects of gossypol acetic acid on CNE2 cells apoptosis. J Pract Med 24: 1009-1101.
18. Zhan WH, Yan G, Shao SP (2008): Observation of apoptotic effect on human prostate cancer cell PC-3 and DU-145 induced by (-)-gossypol. Shandong Medicine 48: 86-87.
19. Qian SZ, Wang ZG (1984): Gossypol: a potential antifertility agent for males. Annu Rev Pharmacol Toxicol 24: 329-360. (Pubitemid 14129539)
20. Ye YX, Bombick D, Hirst K, et al. (1990): The modulation of gap junctional communication by gossypol in various mammalian cell lines in vitro. Fundam Appl Toxicol 14: 817-832. (Pubitemid 20216680)
21. Wang L (1999): Study on effect and mechanism of gossypol in male contraception. Foreign Medical Sciences (Family Planning/Reproductive Health Fascicle): 197-199.
22. Quintana PJ, de Peyster A, Klatzke S, Park HJ (2000): Gossypol-induced DNA breaks in rat lymphocytes are secondary to cytotoxicity. Toxicol Lett 117: 85-94.
23. Yurtcu E, Ergun MA, Menevse A (2003): Apoptotic effect of gossypol on human lymphocytes. Cell Biol Int 27: 791-794. (Pubitemid 37101363)
24. th ed. W.H. Freeman & Co Ltd.; 37-44.
25. Xu WB, Xu LH, Lu HS, et al. (2009): The immunosuppressive effect of gossypol in mice is mediated by inhibition of lymphocyte proliferation and by induction of cell apoptosis. Acta Pharmacol Sin 30: 597-604.
26. Benhaim P, Mathes SJ, Hunt TK, et al. (1994): Induction of neutrophil Mac-1 integrin expression and superoxide production by the medicinal plant extract gossypol. Inflammation 18: 443-458. (Pubitemid 24319066)
27. Fitzpatrick LR, Bostwick JS, Renzetti M, et al. (1990): Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat. Agents Actions 30: 393-402. (Pubitemid 20185150)
28. Yu BZ, Rogers J, Ranadive G, et al. (1997): Gossypol modification of Ala-1 of secreted phospholipase A2: a probe for the kinetic effects of sulfate glycoconjugates. Biochemistry 36: 12400-12411. (Pubitemid 27446662)
29. Chen SD, Xu Y, Zeng ZP (2007): A study on the effects of gossypol acetate on fertility of male mice. J Guangdong Col Pharm 2: 172-174.
30. Ojha P, Dhar JD, Dwivedi AK, et al. (2008): Rat testicular germ cell type(s) targeted by anti-spermatogenic agents in vivo and their recovery on withdrawal of treatment - a flow cytometric study. Anim Reprod Sci 103: 135-148. (Pubitemid 350101975)