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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 9, 2013, Pages 2619-2623

Synthesis and anti-H5N1 activity of chiral gossypol derivatives and its analogs implicated by a viral entry blocking mechanism

(8) Yang, Jian a Chen, Gang a,b Li, Long Long a,b Pan, Wei b Zhang, Fang a,b Yang, Jingxiang a,b Wu, Shuwen b Tien, Po b

a RENMIN HOSPITAL OF WUHAN UNIVERSITY (China)

b WUHAN UNIVERSITY (China)

Author keywords

Amino acid derivative; Analog; Avian influenza virus; Blocking viral entry; Chiral gossypol; d Glucosamine derivative

Indexed keywords

AMINO ACID; ANTIVIRUS AGENT; BLOCKING AGENT; GOSSYPOL DERIVATIVE; DRUG DERIVATIVE; GOSSYPOL; HEMAGGLUTININ;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CHIRALITY; CONTROLLED STUDY; DRUG SYNTHESIS; IN VITRO STUDY; INFLUENZA VIRUS A H5N1; NONHUMAN; PROTEIN TARGETING; VIRUS ENTRY; BINDING SITE; CHEMISTRY; DRUG EFFECT; METABOLISM; MOLECULAR DOCKING; PROTEIN TERTIARY STRUCTURE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AVIAN INFLUENZA VIRUS;

AMINO ACIDS; ANTIVIRAL AGENTS; BINDING SITES; GOSSYPOL; HEMAGGLUTININS; INFLUENZA A VIRUS, H5N1 SUBTYPE; MOLECULAR DOCKING SIMULATION; PROTEIN STRUCTURE, TERTIARY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS INTERNALIZATION;

EID: 84876148121 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.02.101 Document Type: Article

Times cited : (29)

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