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Volumn 6, Issue 3, 2014, Pages 214-230

The p53/miR-34 axis in development and disease

Author keywords

cancer; metastasis; miR 34; miR 34a; miR 34b c; p53; tumor suppression

Indexed keywords

MICRORNA; MICRORNA 34A; PROTEIN P53;

EID: 84901704452     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mju003     Document Type: Review
Times cited : (288)

References (193)
  • 1
    • 84875692592 scopus 로고    scopus 로고
    • Altered microRNA expression profiles of human spermatozoa in patients with different spermato-genic impairments
    • Abu-Halima, M., Hammadeh, M., Schmitt, J., et al. (2013). Altered microRNA expression profiles of human spermatozoa in patients with different spermato-genic impairments. Fertil. Steril. 99, 1249-1255. e16.
    • (2013) Fertil. Steril. , vol.99
    • Abu-Halima, M.1    Hammadeh, M.2    Schmitt, J.3
  • 2
    • 84855495456 scopus 로고    scopus 로고
    • MicroRNA-34a regulates neurite outgrowth, spinal morphology, and function
    • Agostini, M., Tucci, P., Steinert, J. R., et al. (2011). microRNA-34a regulates neurite outgrowth, spinal morphology, and function. Proc. Natl Acad. Sci. USA 108, 21099-21104.
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 21099-21104
    • Agostini, M.1    Tucci, P.2    Steinert, J.R.3
  • 3
    • 84865973348 scopus 로고    scopus 로고
    • ZEB1 drivesprometastatic actin cytoskeletal remodeling by downregulating miR-34a expression
    • Ahn, Y. H., Gibbons, D. L., Chakravarti, D., et al. (2012). ZEB1 drivesprometastatic actin cytoskeletal remodeling by downregulating miR-34a expression. J. Clin. Invest. 122, 3170-3183.
    • (2012) J. Clin. Invest. , vol.122 , pp. 3170-3183
    • Ahn, Y.H.1    Gibbons, D.L.2    Chakravarti, D.3
  • 4
    • 84862855868 scopus 로고    scopus 로고
    • Analysisofserum micro-RNAs as potential biomarker in chronic obstructive pulmonary disease
    • Akbas, F., Coskunpinar, E., Aynaci, E., et al. (2012). Analysisofserum micro-RNAs as potential biomarker in chronic obstructive pulmonary disease. Exp. Lung Res. 38, 286-294.
    • (2012) Exp. Lung Res. , vol.38 , pp. 286-294
    • Akbas, F.1    Coskunpinar, E.2    Aynaci, E.3
  • 5
    • 79961058496 scopus 로고    scopus 로고
    • MiR-34a regulates mouse neural stem cell differentiation
    • Aranha, M. M., Santos, D. M., Solá, S., et al. (2011). miR-34a regulates mouse neural stem cell differentiation. PLoS One 6, e21396.
    • (2011) PLoS One , vol.6
    • Aranha, M.M.1    Santos, D.M.2    Solá, S.3
  • 6
    • 84869219338 scopus 로고    scopus 로고
    • MiR-34-a microRNA replacement therapy is headed to the clinic
    • Bader, A. G. (2012). miR-34-a microRNA replacement therapy is headed to the clinic. Front. Genet. 3, 120.
    • (2012) Front. Genet. , vol.3 , pp. 120
    • Bader, A.G.1
  • 7
    • 84863531464 scopus 로고    scopus 로고
    • MiRNA-34c regulates Notch signaling during bone development
    • Bae, Y., Yang, T., Zeng, H.-C., et al. (2012). miRNA-34c regulates Notch signaling during bone development. Hum. Mol. Genet. 21, 2991-3000.
    • (2012) Hum. Mol. Genet. , vol.21 , pp. 2991-3000
    • Bae, Y.1    Yang, T.2    Zeng, H.-C.3
  • 8
    • 79960140833 scopus 로고    scopus 로고
    • MiR-335 and miR-34a promoterenal senescence by suppressing mitochondrial antioxidative enzymes
    • Bai, X.-Y., Ma, Y., Ding, R., et al. (2011). miR-335 and miR-34a promoterenal senescence by suppressing mitochondrial antioxidative enzymes. J. Am. Soc. Nephrol. 22, 1252-1261.
    • (2011) J. Am. Soc. Nephrol. , vol.22 , pp. 1252-1261
    • Bai, X.-Y.1    Ma, Y.2    Ding, R.3
  • 9
    • 84862680867 scopus 로고    scopus 로고
    • MicroRNA-449 and microRNA-34b/c function redundantly in murine testes by targeting E2F transcription factor-retinoblastoma protein (E2F-pRb) pathway
    • Bao, J., Li, D., Wang, L., et al. (2012). MicroRNA-449 and microRNA-34b/c function redundantly in murine testes by targeting E2F transcription factor-retinoblastoma protein (E2F-pRb) pathway. J. Biol. Chem. 287, 21686-21698.
    • (2012) J. Biol. Chem. , vol.287 , pp. 21686-21698
    • Bao, J.1    Li, D.2    Wang, L.3
  • 10
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel, D. P. (2004). MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 11
    • 84885121957 scopus 로고    scopus 로고
    • Effects of microRNAs on fucosyltransferase 8 (FUT8) expression in hepatocarcinoma cells
    • Bernardi, C., Soffientini, U., Piacente, F., et al. (2013). Effects of microRNAs on fucosyltransferase 8 (FUT8) expression in hepatocarcinoma cells. PLoS One 8, e76540.
    • (2013) PLoS One , vol.8
    • Bernardi, C.1    Soffientini, U.2    Piacente, F.3
  • 12
    • 84867903854 scopus 로고    scopus 로고
    • Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function
    • Bernardo, B. C., Gao, X.-M., Winbanks, C. E., et al. (2012). Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function. Proc. Natl Acad. Sci. USA 109, 17615-17620.
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 17615-17620
    • Bernardo, B.C.1    Gao, X.-M.2    Winbanks, C.E.3
  • 14
    • 84874700585 scopus 로고    scopus 로고
    • MicroRNA-34a regulates cardiac ageing and function
    • Boon, R. A., Iekushi, K., Lechner, S., et al. (2013). MicroRNA-34a regulates cardiac ageing and function. Nature 495, 107-110.
    • (2013) Nature , vol.495 , pp. 107-110
    • Boon, R.A.1    Iekushi, K.2    Lechner, S.3
  • 15
    • 77950199191 scopus 로고    scopus 로고
    • Role of miR-34c microRNA in the late steps of spermatogenesis
    • Bouhallier, F., Allioli, N., Lavial, F., et al. (2010). Role of miR-34c microRNA in the late steps of spermatogenesis. RNA 16, 720-731.
    • (2010) RNA , vol.16 , pp. 720-731
    • Bouhallier, F.1    Allioli, N.2    Lavial, F.3
  • 16
    • 70349443284 scopus 로고    scopus 로고
    • When mutants gain new powers: News from the mutant p53 field
    • Brosh, R., and Rotter, V. (2009). When mutants gain new powers: news from the mutant p53 field. Nat. Rev. Cancer 9, 701-713.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 701-713
    • Brosh, R.1    Rotter, V.2
  • 17
    • 84877263242 scopus 로고    scopus 로고
    • A microRNA miR-34a-regulated bimodal switch targets notch in colon cancer stem cells
    • Bu, P., Chen, K.-Y., Chen, JH, Joyce, H., et al. (2013). A microRNA miR-34a-regulated bimodal switch targets notch in colon cancer stem cells. Cell Stem Cell 12, 602-615.
    • (2013) Cell Stem Cell , vol.12 , pp. 602-615
    • Bu, P.1    Chen, K.-Y.2    Chen, J.H.3    Joyce, H.4
  • 18
    • 44649163918 scopus 로고    scopus 로고
    • A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    • DOI 10.1038/embor.2008.74, PII EMBOR200874
    • Burk, U., Schubert, J., Wellner, U., et al. (2008). A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 9, 582-589. (Pubitemid 351772923)
    • (2008) EMBO Reports , vol.9 , Issue.6 , pp. 582-589
    • Burk, U.1    Schubert, J.2    Wellner, U.3    Schmalhofer, O.4    Vincan, E.5    Spaderna, S.6    Brabletz, T.7
  • 19
    • 84877155928 scopus 로고    scopus 로고
    • Expression and regulatory function of miRNA-34a in targetingsurvivin in gastric cancercells
    • Cao, W., Fan, R., Wang, L., et al. (2013). Expression and regulatory function of miRNA-34a in targetingsurvivin in gastric cancercells. Tumour Biol. 34, 963-971.
    • (2013) Tumour Biol. , vol.34 , pp. 963-971
    • Cao, W.1    Fan, R.2    Wang, L.3
  • 20
    • 84871221881 scopus 로고    scopus 로고
    • MiR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
    • Castro, R. E., Ferreira, D. M., Afonso, M. B., et al. (2013). miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. J. Hepatol. 58, 119-125.
    • (2013) J. Hepatol. , vol.58 , pp. 119-125
    • Castro, R.E.1    Ferreira, D.M.2    Afonso, M.B.3
  • 21
    • 80052008851 scopus 로고    scopus 로고
    • Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease
    • Cermelli, S., Ruggieri, A., Marrero, J. A., et al. (2011). Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease. PLoS One 6, e23937.
    • (2011) PLoS One , vol.6
    • Cermelli, S.1    Ruggieri, A.2    Marrero, J.A.3
  • 23
    • 80052831075 scopus 로고    scopus 로고
    • MicroRNA-34a modulates genes involved in cellular motility and oxidative phosphorylation in neural precursors derived from human umbilical cord mesenchymal stem cells
    • Chang, S.-J., Weng, S.-L., Hsieh, J.-Y., et al. (2011). MicroRNA-34a modulates genes involved in cellular motility and oxidative phosphorylation in neural precursors derived from human umbilical cord mesenchymal stem cells. BMC Med. Genomics 4, 65.
    • (2011) BMC Med. Genomics , vol.4 , pp. 65
    • Chang, S.-J.1    Weng, S.-L.2    Hsieh, J.-Y.3
  • 24
    • 79955410765 scopus 로고    scopus 로고
    • Systematic proteome analysis identifies transcription factor YY1 as a direct target of miR-34a
    • Chen, Q. R., Yu, L. R., Tsang, P., et al. (2011). Systematic proteome analysis identifies transcription factor YY1 as a direct target of miR-34a. J. Proteome Res. 10, 479-487.
    • (2011) J. Proteome Res. , vol.10 , pp. 479-487
    • Chen, Q.R.1    Yu, L.R.2    Tsang, P.3
  • 25
    • 58149386462 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression
    • Cheung, O., Puri, P., Eicken, C., et al. (2008). Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression. Hepatology 48, 1810-1820.
    • (2008) Hepatology , vol.48 , pp. 1810-1820
    • Cheung, O.1    Puri, P.2    Eicken, C.3
  • 26
    • 84880323002 scopus 로고    scopus 로고
    • Correlation between microRNA-34a levels and lens opacity severity in age-related cataracts
    • Chien, K. H., Chen, S. J., Liu, J. H., et al. (2013). Correlation between microRNA-34a levels and lens opacity severity in age-related cataracts. Eye 27, 883-888.
    • (2013) Eye , vol.27 , pp. 883-888
    • Chien, K.H.1    Chen, S.J.2    Liu, J.H.3
  • 27
    • 80455149978 scopus 로고    scopus 로고
    • MiR-34 miRNAs provide a barrier for somatic cell reprogramming
    • Choi, Y. J., Lin, C.-P., Ho, J. J., et al. (2011). miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat. Cell Biol. 13, 1353-1360.
    • (2011) Nat. Cell Biol. , vol.13 , pp. 1353-1360
    • Choi, Y.J.1    Lin, C.-P.2    Ho, J.J.3
  • 28
    • 84888131014 scopus 로고    scopus 로고
    • Elevated microRNA-34a in obesity reduces NAD(+) levels and SIRT1 activity by directly targeting NAMPT
    • Choi, S.-E., Fu, T., Seok, S., et al. (2013). Elevated microRNA-34a in obesity reduces NAD(+) levels and SIRT1 activity by directly targeting NAMPT. Aging Cell 12, 1062-1072.
    • (2013) Aging Cell , vol.12 , pp. 1062-1072
    • Choi, S.-E.1    Fu, T.2    Seok, S.3
  • 29
    • 74249124132 scopus 로고    scopus 로고
    • P53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC
    • Christoffersen, N. R., Shalgi, R., Frankel, L. B., et al. (2010). p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Cell Death Differ. 17, 236-245.
    • (2010) Cell Death Differ. , vol.17 , pp. 236-245
    • Christoffersen, N.R.1    Shalgi, R.2    Frankel, L.B.3
  • 30
    • 49749150980 scopus 로고    scopus 로고
    • A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene
    • Cole, K. A., Attiyeh, E. F., Mosse, Y. P., et al. (2008). A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene. Mol. Cancer Res. 6, 735-742.
    • (2008) Mol. Cancer Res. , vol.6 , pp. 735-742
    • Cole, K.A.1    Attiyeh, E.F.2    Mosse, Y.P.3
  • 31
    • 84864584473 scopus 로고    scopus 로고
    • Intact p53-dependent responses in miR-34-deficient mice
    • Concepcion, C. P., Han, Y.-C., Mu, P., et al. (2012). Intact p53-dependent responses in miR-34-deficient mice. PLoS Genet. 8, e1002797.
    • (2012) PLoS Genet. , vol.8
    • Concepcion, C.P.1    Han, Y.-C.2    Mu, P.3
  • 32
    • 34548803950 scopus 로고    scopus 로고
    • MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth
    • DOI 10.1158/0008-5472.CAN-07-1585
    • Corney, D. C., Flesken-Nikitin, A., Godwin, A. K., et al. (2007). MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in controlof cell proliferation and adhesion-independent growth. Cancer Res. 67, 8433-8438. (Pubitemid 47437414)
    • (2007) Cancer Research , vol.67 , Issue.18 , pp. 8433-8438
    • Corney, D.C.1    Flesken-Nikitin, A.2    Godwin, A.K.3    Wang, W.4    Nikitin, A.Yu.5
  • 33
    • 79959387359 scopus 로고    scopus 로고
    • Myc-mediated repression of microRNA-34a promotes high-grade transformation of B-cell lymphoma by dysregulation of FoxP1
    • Craig, V. J., Cogliatti, S. B., Imig, J., et al. (2011). Myc-mediated repression of microRNA-34a promotes high-grade transformation of B-cell lymphoma by dysregulation of FoxP1. Blood 117, 6227-6236.
    • (2011) Blood , vol.117 , pp. 6227-6236
    • Craig, V.J.1    Cogliatti, S.B.2    Imig, J.3
  • 34
    • 84869083907 scopus 로고    scopus 로고
    • Systemic microRNA-34a delivery induces apoptosis and abrogates growth of diffuse large B-cell lymphoma in vivo
    • Craig, V. J., Tzankov, A., Flori, M., et al. (2012). Systemic microRNA-34a delivery induces apoptosis and abrogates growth of diffuse large B-cell lymphoma in vivo. Leukemia 26, 2421-2424.
    • (2012) Leukemia , vol.26 , pp. 2421-2424
    • Craig, V.J.1    Tzankov, A.2    Flori, M.3
  • 35
    • 84876042176 scopus 로고    scopus 로고
    • Underexpression ofmiR-34a inhepato-cellular carcinoma and its contribution towards enhancement of proliferating inhibitory effects of agents targeting c-MET
    • Dang, Y., Luo, D., Rong, M., et al. (2013). Underexpression ofmiR-34a inhepato-cellular carcinoma and its contribution towards enhancement of proliferating inhibitory effects of agents targeting c-MET. PLoS One 8, e61054.
    • (2013) PLoS One , vol.8
    • Dang, Y.1    Luo, D.2    Rong, M.3
  • 36
    • 80052632447 scopus 로고    scopus 로고
    • + tumor-propagating cells andsupports neuraldifferentiationinmedulloblastoma
    • + tumor-propagating cells andsupports neuraldifferentiationinmedulloblastoma. PLoS One6, e24584.
    • (2011) PLoS One , vol.6
    • De Antonellis, P.1    Medaglia, C.2    Cusanelli, E.3
  • 37
    • 84873050284 scopus 로고    scopus 로고
    • Regulatory networks defining EMT during cancer initiation and progression
    • De Craene, B., and Berx, G. (2013). Regulatory networks defining EMT during cancer initiation and progression. Nat. Rev. Cancer 13, 97-110.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 97-110
    • De Craene, B.1    Berx, G.2
  • 38
    • 84890121012 scopus 로고    scopus 로고
    • Alternative polyadenyla-tion and miR-34 family members regulate tau expression
    • Dickson, J. R., Kruse, C., Montagna, D. R., et al. (2013). Alternative polyadenyla-tion and miR-34 family members regulate tau expression. J. Neurochem. 127, 739-749.
    • (2013) J. Neurochem. , vol.127 , pp. 739-749
    • Dickson, J.R.1    Kruse, C.2    Montagna, D.R.3
  • 39
    • 84880298880 scopus 로고    scopus 로고
    • Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis
    • Dong, P., Karaayvaz, M., Jia, N., et al. (2013). Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis. Oncogene 32, 3286-3295.
    • (2013) Oncogene , vol.32 , pp. 3286-3295
    • Dong, P.1    Karaayvaz, M.2    Jia, N.3
  • 40
    • 84857147817 scopus 로고    scopus 로고
    • Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells
    • Du, R., Sun, W., Xia, L., et al. (2012). Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells. PLoS One 7, e30771.
    • (2012) PLoS One , vol.7
    • Du, R.1    Sun, W.2    Xia, L.3
  • 41
    • 84881363206 scopus 로고    scopus 로고
    • Ectopic expression ofmiR-34a enhances radiosensitivity of non-small cell lung cancer cells, partly by suppressing the LyGDI signaling pathway
    • Duan, W., Xu, Y., Dong, Y., et al. (2013). Ectopic expression ofmiR-34a enhances radiosensitivity of non-small cell lung cancer cells, partly by suppressing the LyGDI signaling pathway. J. Radiat. Res. 54, 611-619.
    • (2013) J. Radiat. Res. , vol.54 , pp. 611-619
    • Duan, W.1    Xu, Y.2    Dong, Y.3
  • 42
    • 84883616225 scopus 로고    scopus 로고
    • Deregulated serum concentrations of circulating cell-free microRNAs miR-17, miR-34a, miR-155, and miR-373 in human breast cancer development and progression
    • Eichelser, C., Flesch-Janys, D., Chang-Claude, J., et al. (2013). Deregulated serum concentrations of circulating cell-free microRNAs miR-17, miR-34a, miR-155, and miR-373 in human breast cancer development and progression. Clin. Chem. 59, 1489-1496
    • (2013) Clin. Chem. , vol.59 , pp. 1489-1496
    • Eichelser, C.1    Flesch-Janys, D.2    Chang-Claude, J.3
  • 43
    • 0026849821 scopus 로고
    • Definition of a consensus binding site for p53
    • el-Deiry, W. S., Kern, S. E., Pietenpol, J. A., et al. (1992). Definition of a consensus binding site for p53. Nat. Genet. 1, 45-49.
    • (1992) Nat. Genet. , vol.1 , pp. 45-49
    • El-Deiry, W.S.1    Kern, S.E.2    Pietenpol, J.A.3
  • 44
    • 84881342630 scopus 로고    scopus 로고
    • MicroRNA-34a promotes cardiomyocyte apoptosis post myocardial infarction through down-regulating aldehyde de-hydrogenase 2
    • Fan, F., Sun, A., Zhao, H., et al. (2013). MicroRNA-34a promotes cardiomyocyte apoptosis post myocardial infarction through down-regulating aldehyde de-hydrogenase 2. Curr. Pharm. Des. 19, 4865-4873.
    • (2013) Curr. Pharm. Des. , vol.19 , pp. 4865-4873
    • Fan, F.1    Sun, A.2    Zhao, H.3
  • 45
    • 33744783432 scopus 로고    scopus 로고
    • Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    • DOI 10.1016/j.ccr.2006.04.023, PII S1535610806001450
    • Fantin, V. R., St-Pierre, J., and Leder, P. (2006). Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 9, 425-434. (Pubitemid 43832190)
    • (2006) Cancer Cell , vol.9 , Issue.6 , pp. 425-434
    • Fantin, V.R.1    St-Pierre, J.2    Leder, P.3
  • 46
    • 84894522273 scopus 로고    scopus 로고
    • Heatshock improvessca-1stemcells survival and directs ischemic cardiomyocytes towards a prosurvival phenotype via exosomal transfer: A critical role for HSF1/miR-34a/HSP70 pathway
    • Feng, Y., Huang, W., Meng, W., et al. (2014). Heatshock improvessca-1stemcells survival and directs ischemic cardiomyocytes towards a prosurvival phenotype via exosomal transfer: a critical role for HSF1/miR-34a/HSP70 pathway. Stem Cells 32, 462-472.
    • (2014) Stem Cells , vol.32 , pp. 462-472
    • Feng, Y.1    Huang, W.2    Meng, W.3
  • 47
    • 84862173056 scopus 로고    scopus 로고
    • MiR-34a represses Numbl in murine neural progenitor cells and antagonizes neuronal differentiation
    • Fineberg, S. K., Datta, P., Stein, C. S., et al. (2012). MiR-34a represses Numbl in murine neural progenitor cells and antagonizes neuronal differentiation. PLoS One 7, e38562.
    • (2012) PLoS One , vol.7
    • Fineberg, S.K.1    Datta, P.2    Stein, C.S.3
  • 48
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAsare conserved targets of microRNAs
    • Friedman, R. C., Farh, K. K., Burge, C. B., et al. (2009). Most mammalian mRNAsare conserved targets of microRNAs. Genome Res. 19, 92-105.
    • (2009) Genome Res. , vol.19 , pp. 92-105
    • Friedman, R.C.1    Farh, K.K.2    Burge, C.B.3
  • 49
    • 84867068010 scopus 로고    scopus 로고
    • Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting amembrane cor-eceptor b-Klotho
    • Fu, T., Choi, S.-E., Kim, D.-H., et al. (2012). Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting amembrane cor-eceptor b-Klotho. Proc. Natl Acad. Sci. USA 109, 16137-16142.
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 16137-16142
    • Fu, T.1    Choi, S.-E.2    Kim, D.-H.3
  • 50
    • 54449092239 scopus 로고    scopus 로고
    • Effects ofmiR-34aoncell growth and chemoresistance in prostate cancer PC3 cells
    • Fujita, Y., Kojima, K., Hamada, N., et al. (2008). Effects ofmiR-34aoncell growth and chemoresistance in prostate cancer PC3 cells. Biochem. Biophys. Res. Commun. 377, 114-119.
    • (2008) Biochem. Biophys. Res. Commun. , vol.377 , pp. 114-119
    • Fujita, Y.1    Kojima, K.2    Hamada, N.3
  • 51
    • 70849087385 scopus 로고    scopus 로고
    • MiR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer
    • Gallardo, E., Navarro, A., Viñolas, N., et al. (2009). miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer. Carcinogenesis 30, 1903-1909.
    • (2009) Carcinogenesis , vol.30 , pp. 1903-1909
    • Gallardo, E.1    Navarro, A.2    Viñolas, N.3
  • 52
    • 84879267458 scopus 로고    scopus 로고
    • MiR-34a/c-dependent PDGFR-alpha/beta downregulation inhibits tumorigenesis and enhances TRAIL-induced apoptosis in lung cancer
    • Garofalo, M., Jeon, Y. J., Nuovo, G. J., et al. (2013). MiR-34a/c-dependent PDGFR-alpha/beta downregulation inhibits tumorigenesis and enhances TRAIL-induced apoptosis in lung cancer. PLoS One 8, e67581.
    • (2013) PLoS One , vol.8
    • Garofalo, M.1    Jeon, Y.J.2    Nuovo, G.J.3
  • 53
    • 79956032718 scopus 로고    scopus 로고
    • Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease
    • Gaughwin, P. M., Ciesla, M., Lahiri, N., et al. (2011). Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease. Hum. Mol. Genet. 20, 2225-2237.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 2225-2237
    • Gaughwin, P.M.1    Ciesla, M.2    Lahiri, N.3
  • 54
    • 78650015522 scopus 로고    scopus 로고
    • The role of mutant p53 in human cancer
    • Goh, A. M., Coffill, C. R., and Lane, D. P. (2011). The role of mutant p53 in human cancer. J. Pathol. 223, 116-126.
    • (2011) J. Pathol. , vol.223 , pp. 116-126
    • Goh, A.M.1    Coffill, C.R.2    Lane, D.P.3
  • 56
    • 79959805791 scopus 로고    scopus 로고
    • MiR-34a inhibits lymphatic metastasis potential of mouse hepatoma cells
    • Guo, Y., Li, S., Qu, J., et al. (2011). MiR-34a inhibits lymphatic metastasis potential of mouse hepatoma cells. Mol. Cell. Biochem. 354, 275-282.
    • (2011) Mol. Cell. Biochem. , vol.354 , pp. 275-282
    • Guo, Y.1    Li, S.2    Qu, J.3
  • 57
    • 84859768278 scopus 로고    scopus 로고
    • Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity
    • Hagiwara, K., Kosaka, N., Yoshioka, Y., et al. (2012). Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity. Sci. Rep. 2, 314.
    • (2012) Sci. Rep. , vol.2 , pp. 314
    • Hagiwara, K.1    Kosaka, N.2    Yoshioka, Y.3
  • 58
    • 84888875112 scopus 로고    scopus 로고
    • SNAIL and miR-34a feedforward regulation ofZNF281/ZBP99 promotes epithelial-mesenchymal transition
    • Hahn, S., Jackstadt, R., Siemens, H., et al. (2013). SNAIL and miR-34a feedforward regulation ofZNF281/ZBP99 promotes epithelial-mesenchymal transition. EMBO J. 32, 3079-3095.
    • (2013) EMBO J. , vol.32 , pp. 3079-3095
    • Hahn, S.1    Jackstadt, R.2    Siemens, H.3
  • 59
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D., and Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. Cell 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 60
    • 80053634170 scopus 로고    scopus 로고
    • MicroRNA as repressors of stress-induced anxiety: The case of amygdalar miR-34
    • Haramati, S., Navon, I., Issler, O., et al. (2011). MicroRNA as repressors of stress-induced anxiety: the case of amygdalar miR-34. J. Neurosci. 31, 14191-14203.
    • (2011) J. Neurosci. , vol.31 , pp. 14191-14203
    • Haramati, S.1    Navon, I.2    Issler, O.3
  • 61
    • 67651098994 scopus 로고    scopus 로고
    • MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1in the coordinate regulation of dendritic cell differentiation
    • Hashimi, S. T., Fulcher, J. A., Chang, M. H., et al. (2009). MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1in the coordinate regulation of dendritic cell differentiation. Blood 114, 404-414.
    • (2009) Blood , vol.114 , pp. 404-414
    • Hashimi, S.T.1    Fulcher, J.A.2    Chang, M.H.3
  • 63
    • 84867081983 scopus 로고    scopus 로고
    • Systemic miRNAsaspoten-tial biomarkers for malignancy
    • Healy, N. A., Heneghan, H. M., Miller, N., et al. (2012). Systemic miRNAsaspoten-tial biomarkers for malignancy. Int. J. Cancer 131, 2215-2222.
    • (2012) Int. J. Cancer , vol.131 , pp. 2215-2222
    • Healy, N.A.1    Heneghan, H.M.2    Miller, N.3
  • 64
    • 35748961986 scopus 로고    scopus 로고
    • P53 enters the microRNAworld
    • Hermeking, H. (2007). p53 enters the microRNAworld. Cancer Cell 12, 414-418.
    • (2007) Cancer Cell , vol.12 , pp. 414-418
    • Hermeking, H.1
  • 65
    • 84866423871 scopus 로고    scopus 로고
    • MicroRNAs in the p53 network: Micromanagement of tumour suppression
    • Hermeking, H. (2012). MicroRNAs in the p53 network: micromanagement of tumour suppression. Nat. Rev. Cancer 12, 613-626.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 613-626
    • Hermeking, H.1
  • 67
    • 84866481943 scopus 로고    scopus 로고
    • MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neurone cell apop-tosis post-status epilepticus
    • Hu, K., Xie, Y.-Y., Zhang, C., et al. (2012). MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neurone cell apop-tosis post-status epilepticus. BMC Neurosci. 13, 115.
    • (2012) BMC Neurosci. , vol.13 , pp. 115
    • Hu, K.1    Xie, Y.-Y.2    Zhang, C.3
  • 68
    • 84861212776 scopus 로고    scopus 로고
    • MicroRNA-34a and microRNA-21 play roles in the chemopreventive effects of 3, 6-dihydroxyflavone on 1-methyl-1-nitrosourea-induced breast carcinogenesis
    • Hui, C., Yujie, F., Lijia, Y., et al. (2012). MicroRNA-34a and microRNA-21 play roles in the chemopreventive effects of 3, 6-dihydroxyflavone on 1-methyl-1-nitrosourea-induced breast carcinogenesis. Breast Cancer Res. 14, R80.
    • (2012) Breast Cancer Res. , vol.14
    • Hui, C.1    Yujie, F.2    Lijia, Y.3
  • 69
    • 80052183233 scopus 로고    scopus 로고
    • Wild-type p53 controls cell motility and invasion by dual regulation of MET expression
    • Hwang, C.-I., Matoso, A., Corney, D. C., et al. (2011). Wild-type p53 controls cell motility and invasion by dual regulation of MET expression. Proc. Natl Acad. Sci. USA 108, 14240-14245.
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 14240-14245
    • Hwang, C.-I.1    Matoso, A.2    Corney, D.C.3
  • 70
    • 77952330677 scopus 로고    scopus 로고
    • MicroRNA-34a inhibits cell proliferation by repressing mitogen-activated protein kinase kinase 1 during megakaryocytic differentiation of K562 cells
    • Ichimura, A., Ruike, Y., Terasawa, K., et al. (2010). MicroRNA-34a inhibits cell proliferation by repressing mitogen-activated protein kinase kinase 1 during megakaryocytic differentiation of K562 cells. Mol. Pharmacol. 77, 1016-1024.
    • (2010) Mol. Pharmacol. , vol.77 , pp. 1016-1024
    • Ichimura, A.1    Ruike, Y.2    Terasawa, K.3
  • 71
    • 77955417245 scopus 로고    scopus 로고
    • MicroRNA-34a regulationof endothe-lial senescence
    • Ito, T., Yagi, S., and Yamakuchi, M. (2010). MicroRNA-34a regulationof endothe-lial senescence. Biochem. Biophys. Res. Commun. 398, 735-740.
    • (2010) Biochem. Biophys. Res. Commun. , vol.398 , pp. 735-740
    • Ito, T.1    Yagi, S.2    Yamakuchi, M.3
  • 72
    • 84857483281 scopus 로고    scopus 로고
    • P53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells
    • Jain, A. K., Allton, K., Iacovino, M., et al. (2012). p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells. PLoS Biol. 10, e1001268.
    • (2012) PLoS Biol. , vol.10
    • Jain, A.K.1    Allton, K.2    Iacovino, M.3
  • 73
    • 53949090314 scopus 로고    scopus 로고
    • Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres
    • Ji, Q., Hao, X., Meng, Y., et al. (2008). Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. BMC Cancer 8, 266.
    • (2008) BMC Cancer , vol.8 , pp. 266
    • Ji, Q.1    Hao, X.2    Meng, Y.3
  • 74
    • 69949087531 scopus 로고    scopus 로고
    • MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells
    • Ji, Q., Hao, X., Zhang, M., et al. (2009). MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLoS One 4, e6816.
    • (2009) PLoS One , vol.4
    • Ji, Q.1    Hao, X.2    Zhang, M.3
  • 75
    • 84867077740 scopus 로고    scopus 로고
    • Delta-tocotrienol suppresses Notch-1 pathway by upregulating miR-34a in nonsmall cell lung cancer cells
    • Ji, X., Wang, Z., Geamanu, A., et al. (2012). Delta-tocotrienol suppresses Notch-1 pathway by upregulating miR-34a in nonsmall cell lung cancer cells. Int. J. Cancer 131, 2668-2677.
    • (2012) Int. J. Cancer , vol.131 , pp. 2668-2677
    • Ji, X.1    Wang, Z.2    Geamanu, A.3
  • 76
    • 79957603048 scopus 로고    scopus 로고
    • Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer
    • Kalimutho, M., Di Cecilia, S., Del Vecchio Blanco, G., et al. (2011). Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer. Br. J. Cancer 104, 1770-1778.
    • (2011) Br. J. Cancer , vol.104 , pp. 1770-1778
    • Kalimutho, M.1    Di Cecilia, S.2    Del Vecchio Blanco, G.3
  • 77
    • 80051613002 scopus 로고    scopus 로고
    • Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis
    • Kaller, M., Liffers, S.-T., Oeljeklaus, S., et al. (2011). Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis. Mol. Cell. Proteomics 10, M111.010462.
    • (2011) Mol. Cell. Proteomics , vol.10
    • Kaller, M.1    Liffers, S.-T.2    Oeljeklaus, S.3
  • 78
    • 84884567357 scopus 로고    scopus 로고
    • Rhamnetin and cirsiliol induce radiosen-sitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines
    • Kang, J., Kim, E., Kim, W., et al. (2013). Rhamnetin and cirsiliol induce radiosen-sitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines. J. Biol. Chem. 288, 27343-27357.
    • (2013) J. Biol. Chem. , vol.288 , pp. 27343-27357
    • Kang, J.1    Kim, E.2    Kim, W.3
  • 79
    • 84868011894 scopus 로고    scopus 로고
    • Inactivation ofAR and Notch-1 signaling by miR-34a attenuates prostate cancer aggressiveness
    • Kashat, M., Azzouz, L., Sarkar, S. H., et al. (2012). Inactivation ofAR and Notch-1 signaling by miR-34a attenuates prostate cancer aggressiveness. Am. J. Transl. Res. 4, 432-442.
    • (2012) Am. J. Transl. Res. , vol.4 , pp. 432-442
    • Kashat, M.1    Azzouz, L.2    Sarkar, S.H.3
  • 80
    • 80455137130 scopus 로고    scopus 로고
    • P53and microRNA-34 aresuppres-sors of canonical Wnt signaling
    • Kim, N. H., Kim, H. S., Kim, N. G., et al. (2011a). p53and microRNA-34 aresuppres-sors of canonical Wnt signaling. Sci. Signal. 4, ra71.
    • (2011) Sci. Signal. , vol.4
    • Kim, N.H.1    Kim, H.S.2    Kim, N.G.3
  • 81
    • 84855729906 scopus 로고    scopus 로고
    • A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition
    • Kim, N. H., Kim, H. S., Li, X.-Y., et al. (2011b). A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. J. Cell Biol. 195, 417-433.
    • (2011) J. Cell Biol. , vol.195 , pp. 417-433
    • Kim, N.H.1    Kim, H.S.2    Li, X.-Y.3
  • 82
    • 79956143950 scopus 로고    scopus 로고
    • P53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
    • Kim, T., Veronese, A., Pichiorri, F., et al. (2011c). p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J. Exp. Med. 208, 875-883.
    • (2011) J. Exp. Med. , vol.208 , pp. 875-883
    • Kim, T.1    Veronese, A.2    Pichiorri, F.3
  • 83
    • 84862777488 scopus 로고    scopus 로고
    • A p53-inducible microRNA-34a downregulates Ras signaling by targeting IMPDH
    • Kim, H.-R., Roe, J.-S., Lee, J.-E., et al. (2012). A p53-inducible microRNA-34a downregulates Ras signaling by targeting IMPDH. Biochem. Biophys. Res. Commun. 418, 682-688.
    • (2012) Biochem. Biophys. Res. Commun. , vol.418 , pp. 682-688
    • Kim, H.-R.1    Roe, J.-S.2    Lee, J.-E.3
  • 85
    • 84877979327 scopus 로고    scopus 로고
    • P53regulatesnuclear GSK-3levels through miR-34-mediated Axin2 suppression in colorectal cancer cells
    • Kim, N. H., Cha, Y. H., Kang, S. E., et al. (2013b). p53regulatesnuclear GSK-3levels through miR-34-mediated Axin2 suppression in colorectal cancer cells. Cell Cycle 12, 1578-1587.
    • (2013) Cell Cycle , vol.12 , pp. 1578-1587
    • Kim, N.H.1    Cha, Y.H.2    Kang, S.E.3
  • 86
    • 77956989411 scopus 로고    scopus 로고
    • MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms
    • Kojima, K., Fujita, Y., Nozawa, Y., et al. (2010). MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms. Prostate 70, 1501-1512.
    • (2010) Prostate , vol.70 , pp. 1501-1512
    • Kojima, K.1    Fujita, Y.2    Nozawa, Y.3
  • 87
    • 79953327099 scopus 로고    scopus 로고
    • Significance of serum microRNAs in pre-diabetes and newlydiagnosed type2diabetes:aclinical study
    • Kong, L., Zhu, J., Han, W., et al. (2011). Significance of serum microRNAs in pre-diabetes and newlydiagnosed type2diabetes:aclinical study. Acta Diabetol. 48, 61-69.
    • (2011) Acta Diabetol. , vol.48 , pp. 61-69
    • Kong, L.1    Zhu, J.2    Han, W.3
  • 88
    • 84863050461 scopus 로고    scopus 로고
    • Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment
    • Kong, D., Heath, E., Chen, W., et al. (2012). Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment. Am. J. Transl. Res. 4, 14-23.
    • (2012) Am. J. Transl. Res. , vol.4 , pp. 14-23
    • Kong, D.1    Heath, E.2    Chen, W.3
  • 89
    • 79951472912 scopus 로고    scopus 로고
    • The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis
    • Kress, T. R., Cannell, I. G., Brenkman, A. B., et al. (2011). The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis. Mol. Cell 41, 445-457.
    • (2011) Mol. Cell , vol.41 , pp. 445-457
    • Kress, T.R.1    Cannell, I.G.2    Brenkman, A.B.3
  • 90
    • 77955902024 scopus 로고    scopus 로고
    • The widespread regulation of microRNA biogenesis, function and decay
    • Krol, J., Loedige, I., and Filipowicz, W. (2010). The widespread regulation of microRNA biogenesis, function and decay. Nat. Rev. Genet. 11, 597-610.
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 597-610
    • Krol, J.1    Loedige, I.2    Filipowicz, W.3
  • 91
    • 84885842225 scopus 로고    scopus 로고
    • Anti-cancer effectsof naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells
    • Kumazaki, M., Noguchi, S., Yasui, Y., et al. (2013). Anti-cancer effectsof naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells. J. Nutr. Biochem. 24, 1849-1858.
    • (2013) J. Nutr. Biochem. , vol.24 , pp. 1849-1858
    • Kumazaki, M.1    Noguchi, S.2    Yasui, Y.3
  • 92
    • 78650316134 scopus 로고    scopus 로고
    • P53 Research: The past thirty years and the next thirty years
    • Lane, D., and Levine, A. (2010). p53 Research: the past thirty years and the next thirty years. Cold Spring Harb. Perspect. Biol. 2, a000893.
    • (2010) Cold Spring Harb. Perspect. Biol. , vol.2
    • Lane, D.1    Levine, A.2
  • 93
    • 77951210885 scopus 로고    scopus 로고
    • A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition
    • Lee, J., Padhye, A., Sharma, A., et al. (2010). A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition. J. Biol. Chem. 285, 12604-12611.
    • (2010) J. Biol. Chem. , vol.285 , pp. 12604-12611
    • Lee, J.1    Padhye, A.2    Sharma, A.3
  • 94
    • 84866691285 scopus 로고    scopus 로고
    • Sirtuin 1 facilitates generation of induced pluripotent stem cells from mouse embryonic fibroblasts through the miR-34a and p53 pathways
    • Lee, Y. L., Peng, Q., Fong, S. W., et al. (2012). Sirtuin 1 facilitates generation of induced pluripotent stem cells from mouse embryonic fibroblasts through the miR-34a and p53 pathways. PLoS One 7, e45633.
    • (2012) PLoS One , vol.7
    • Lee, Y.L.1    Peng, Q.2    Fong, S.W.3
  • 95
    • 84882451168 scopus 로고    scopus 로고
    • A miR-34a-SIRT6 axisin the squa-mous cell differentiation network
    • Lefort, K., Brooks, Y., Ostano, P., et al. (2013). A miR-34a-SIRT6 axisin the squa-mous cell differentiation network. EMBO J. 32, 2248-2263.
    • (2013) EMBO J. , vol.32 , pp. 2248-2263
    • Lefort, K.1    Brooks, Y.2    Ostano, P.3
  • 96
    • 2142758177 scopus 로고    scopus 로고
    • P53isatumor suppressor gene
    • 1 p following S69
    • Levine, A. J., Finlay, C. A., and Hinds, P. W. (2004). P53isatumor suppressor gene. Cell 116 (2 Suppl), S67-S69, 1 p following S69.
    • (2004) Cell , vol.116 , Issue.2 SUPPL.
    • Levine, A.J.1    Finlay, C.A.2    Hinds, P.W.3
  • 97
    • 58549114916 scopus 로고    scopus 로고
    • MiR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells
    • Li, N., Fu, H., Tie, Y., et al. (2009a). miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells. Cancer Lett. 275, 44-53.
    • (2009) Cancer Lett. , vol.275 , pp. 44-53
    • Li, N.1    Fu, H.2    Tie, Y.3
  • 98
    • 70349393847 scopus 로고    scopus 로고
    • Differential expression of microRNAs in mouse liver under aberrant energy metabolic status
    • Li, S., Chen, X., Zhang, H., et al. (2009b). Differential expression of microRNAs in mouse liver under aberrant energy metabolic status. J. Lipid Res. 50, 1756-1765.
    • (2009) J. Lipid Res. , vol.50 , pp. 1756-1765
    • Li, S.1    Chen, X.2    Zhang, H.3
  • 99
    • 70350221952 scopus 로고    scopus 로고
    • MicroRNA-34ainhibits glioblastoma growth by targeting multiple oncogenes
    • Li, Y., Guessous, F., Zhang, Y., et al. (2009c). MicroRNA-34ainhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res. 69, 7569-7576.
    • (2009) Cancer Res. , vol.69 , pp. 7569-7576
    • Li, Y.1    Guessous, F.2    Zhang, Y.3
  • 100
    • 79955065145 scopus 로고    scopus 로고
    • The rno-miR-34 familyisupregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats
    • Li, W.-Q., Chen, C., Xu, M.-D., et al. (2011a). The rno-miR-34 familyisupregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats. FEBS J. 278, 1522-1532.
    • (2011) FEBS J. , vol.278 , pp. 1522-1532
    • Li, W.-Q.1    Chen, C.2    Xu, M.-D.3
  • 101
    • 80855165230 scopus 로고    scopus 로고
    • Circulatory miR34aas an RNAbased, non-invasive biomarker for brain aging
    • Li, X., Khanna, A., Li, N., et al. (2011b). Circulatory miR34aas an RNAbased, non-invasive biomarker for brain aging. Aging 3, 985-1002.
    • (2011) Aging , vol.3 , pp. 985-1002
    • Li, X.1    Khanna, A.2    Li, N.3
  • 102
    • 84861973567 scopus 로고    scopus 로고
    • Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence
    • Li, T., Kon, N., Jiang, L., et al. (2012). Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell 149, 1269-1283.
    • (2012) Cell , vol.149 , pp. 1269-1283
    • Li, T.1    Kon, N.2    Jiang, L.3
  • 103
    • 84859152310 scopus 로고    scopus 로고
    • MicroRNA-34c enhances murine male germ cell apoptosis through targeting ATF1
    • Liang, X., Zhou, D., Wei, C., et al. (2012). MicroRNA-34c enhances murine male germ cell apoptosis through targeting ATF1. PLoS One 7, e33861.
    • (2012) PLoS One , vol.7
    • Liang, X.1    Zhou, D.2    Wei, C.3
  • 104
    • 79751473114 scopus 로고    scopus 로고
    • The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
    • Liu, C., Kelnar, K., Liu, B., et al. (2011). The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat. Med. 17, 211-215.
    • (2011) Nat. Med. , vol.17 , pp. 211-215
    • Liu, C.1    Kelnar, K.2    Liu, B.3
  • 105
    • 84862776753 scopus 로고    scopus 로고
    • The microRNA miR-34 modulates aging and neurodegeneration in Drosophila
    • Liu, N., Landreh, M., Cao, K., et al. (2012a). The microRNA miR-34 modulates aging and neurodegeneration in Drosophila. Nature 482, 519-523.
    • (2012) Nature , vol.482 , pp. 519-523
    • Liu, N.1    Landreh, M.2    Cao, K.3
  • 106
    • 84862908733 scopus 로고    scopus 로고
    • Sperm-borne microRNA-34c is required for the first cleavage division in mouse
    • Liu, W. M., Pang, R. T. K., Chiu, P. C. N., et al. (2012b). Sperm-borne microRNA-34c is required for the first cleavage division in mouse. Proc. Natl Acad. Sci. USA 109, 490-494.
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 490-494
    • Liu, W.M.1    Pang, R.T.K.2    Chiu, P.C.N.3
  • 107
    • 49749126791 scopus 로고    scopus 로고
    • Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer
    • Lodygin, D., Tarasov, V., Epanchintsev, A., et al. (2008). Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer. Cell Cycle 7, 2591-2600.
    • (2008) Cell Cycle , vol.7 , pp. 2591-2600
    • Lodygin, D.1    Tarasov, V.2    Epanchintsev, A.3
  • 108
    • 58149350340 scopus 로고    scopus 로고
    • Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction
    • Lovis, P., Roggli, E., Laybutt, D. R., et al. (2008). Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction. Diabetes 57, 2728-2736.
    • (2008) Diabetes , vol.57 , pp. 2728-2736
    • Lovis, P.1    Roggli, E.2    Laybutt, D.R.3
  • 109
    • 51649083501 scopus 로고    scopus 로고
    • A microRNA DNA methyla-tion signature for human cancer metastasis
    • Lujambio, A., Calin, G. A., Villanueva, A., et al. (2008). A microRNA DNA methyla-tion signature for human cancer metastasis. Proc. Natl Acad. Sci. USA 105, 13556-13561.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 13556-13561
    • Lujambio, A.1    Calin, G.A.2    Villanueva, A.3
  • 110
    • 82955248085 scopus 로고    scopus 로고
    • Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA
    • Mackiewicz, M., Huppi, K., Pitt, J. J., et al. (2011). Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA. Breast Cancer Res. Treat. 130, 663-679.
    • (2011) Breast Cancer Res. Treat. , vol.130 , pp. 663-679
    • Mackiewicz, M.1    Huppi, K.2    Pitt, J.J.3
  • 111
    • 84871970908 scopus 로고    scopus 로고
    • MiRNA-34b inhibits prostate cancer through demethylation, active chromatin modifications, and AKT pathways
    • Majid, S., Dar, A. A., Saini, S., et al. (2013). miRNA-34b inhibits prostate cancer through demethylation, active chromatin modifications, and AKT pathways. Clin. Cancer Res. 19, 73-84.
    • (2013) Clin. Cancer Res. , vol.19 , pp. 73-84
    • Majid, S.1    Dar, A.A.2    Saini, S.3
  • 112
    • 84864755975 scopus 로고    scopus 로고
    • MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame
    • Mandke, P., Wyatt, N., Fraser, J., et al. (2012). MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame. PLoS One 7, e42034.
    • (2012) PLoS One , vol.7
    • Mandke, P.1    Wyatt, N.2    Fraser, J.3
  • 114
    • 79959837062 scopus 로고    scopus 로고
    • SIRT1 promotes N-Myc onco-genesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability
    • Marshall, G. M., Liu, P. Y., Gherardi, S., et al. (2011). SIRT1 promotes N-Myc onco-genesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability. PLoS Genet. 7, e1002135.
    • (2011) PLoS Genet. , vol.7
    • Marshall, G.M.1    Liu, P.Y.2    Gherardi, S.3
  • 115
    • 84880770209 scopus 로고    scopus 로고
    • Circulating p53-responsive microRNAs are predictive indicators of heart failure after acute myocardial infarction
    • Matsumoto, S., Sakata, Y., Suna, S., et al. (2013). Circulating p53-responsive microRNAs are predictive indicators of heart failure after acute myocardial infarction. Circ. Res. 113, 322-326.
    • (2013) Circ. Res. , vol.113 , pp. 322-326
    • Matsumoto, S.1    Sakata, Y.2    Suna, S.3
  • 116
    • 84856384698 scopus 로고    scopus 로고
    • The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
    • Menssen, A., Hydbring, P., Kapelle, K., et al. (2012). The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. Proc. Natl Acad. Sci. USA 109, E187-E196.
    • (2012) Proc. Natl Acad. Sci. USA , vol.109
    • Menssen, A.1    Hydbring, P.2    Kapelle, K.3
  • 117
    • 84863792910 scopus 로고    scopus 로고
    • C-MYC and SIRT1 locked in a vicious cycle
    • Menssen, A., and Hermeking, H. (2012). c-MYC and SIRT1 locked in a vicious cycle. Oncotarget 3, 112-113.
    • (2012) Oncotarget , vol.3 , pp. 112-113
    • Menssen, A.1    Hermeking, H.2
  • 118
    • 79960135400 scopus 로고    scopus 로고
    • MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function
    • Miñones-Moyano, E., Porta, S., Escaraḿis, G., et al. (2011). MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function. Hum. Mol. Genet. 20, 3067-3078.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 3067-3078
    • Miñones-Moyano, E.1    Porta, S.2    Escaraḿis, G.3
  • 120
    • 79959673368 scopus 로고    scopus 로고
    • RegulationofAxl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer
    • Mudduluru, G., Ceppi, P., Kumarswamy, R., et al. (2011). RegulationofAxl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer. Oncogene 30, 2888-2899.
    • (2011) Oncogene , vol.30 , pp. 2888-2899
    • Mudduluru, G.1    Ceppi, P.2    Kumarswamy, R.3
  • 121
    • 0035265686 scopus 로고    scopus 로고
    • PUMA, a novel proapoptotic gene, is induced by p53
    • DOI 10.1016/S1097-2765(01)00214-3
    • Nakano, K., and Vousden, K. H. (2001). PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 7, 683-694. (Pubitemid 32706359)
    • (2001) Molecular Cell , vol.7 , Issue.3 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 122
    • 70349256065 scopus 로고    scopus 로고
    • MiR-34a contributestomegakar-yocytic differentiation of K562 cells independently of p53
    • Navarro, F., Gutman, D., Meire, E., et al. (2009). miR-34a contributestomegakar-yocytic differentiation of K562 cells independently of p53. Blood 114, 2181-2192.
    • (2009) Blood , vol.114 , pp. 2181-2192
    • Navarro, F.1    Gutman, D.2    Meire, E.3
  • 123
    • 84857887315 scopus 로고    scopus 로고
    • Down-regulation of microRNA-34a in rheumatoid arthritis synovial fibroblasts promotes apop-tosis resistance
    • Niederer, F., Trenkmann, M., Ospelt, C., et al. (2012). Down-regulation of microRNA-34a in rheumatoid arthritis synovial fibroblasts promotes apop-tosis resistance. Arthritis Rheum. 64, 1771-1779.
    • (2012) Arthritis Rheum. , vol.64 , pp. 1771-1779
    • Niederer, F.1    Trenkmann, M.2    Ospelt, C.3
  • 124
    • 84869501780 scopus 로고    scopus 로고
    • Circulating miR-34a levels are reduced in colorectal cancer
    • Nugent, M., Miller, N., and Kerin, M. J. (2012). Circulating miR-34a levels are reduced in colorectal cancer. J. Surg. Oncol. 106, 947-952.
    • (2012) J. Surg. Oncol. , vol.106 , pp. 947-952
    • Nugent, M.1    Miller, N.2    Kerin, M.J.3
  • 125
    • 0038075338 scopus 로고    scopus 로고
    • Decision making by p53: Life, death and cancer
    • DOI 10.1038/sj.cdd.4401183
    • Oren, M. (2003). Decision making by p53: life, death and cancer. Cell Death Differ. 10, 431-442. (Pubitemid 36626355)
    • (2003) Cell Death and Differentiation , vol.10 , Issue.4 , pp. 431-442
    • Oren, M.1
  • 126
    • 79952205258 scopus 로고    scopus 로고
    • Systematic analysis of microRNAs targeting the androgen receptor in prostate cancer cells
    • Ostling, P., Leivonen, S.-K., Aakula, A., et al. (2011). Systematic analysis of microRNAs targeting the androgen receptor in prostate cancer cells. Cancer Res. 71, 1956-1967.
    • (2011) Cancer Res. , vol.71 , pp. 1956-1967
    • Ostling, P.1    Leivonen, S.-K.2    Aakula, A.3
  • 127
    • 84872908276 scopus 로고    scopus 로고
    • MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1
    • Pang, R. T., Leung, C. O., Lee, C.-L., et al. (2013). MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1. BMC Cancer 13, 25.
    • (2013) BMC Cancer , vol.13 , pp. 25
    • Pang, R.T.1    Leung, C.O.2    Lee, C.-L.3
  • 128
    • 84858446579 scopus 로고    scopus 로고
    • MicroRNAs and their targets: Recognition, regulation and an emerging reciprocal relationship
    • Pasquinelli, A. E. (2012). MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nat. Rev. Genet. 13, 271-282.
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 271-282
    • Pasquinelli, A.E.1
  • 129
    • 34248379012 scopus 로고    scopus 로고
    • Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: Lessons from recent developments in the IARC TP53 database
    • DOI 10.1002/humu.20495
    • Petitjean, A., Mathe, E., Kato, S., et al. (2007). Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum. Mutat. 28, 622-629. (Pubitemid 46744292)
    • (2007) Human Mutation , vol.28 , Issue.6 , pp. 622-629
    • Petitjean, A.1    Mathe, E.2    Kato, S.3    Ishioka, C.4    Tavtigian, S.V.5    Hainaut, P.6    Olivier, M.7
  • 130
    • 65549124181 scopus 로고    scopus 로고
    • MiR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia
    • Pigazzi, M., Manara, E., Baron, E., et al. (2009). miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia. Cancer Res. 69, 2471-2478.
    • (2009) Cancer Res. , vol.69 , pp. 2471-2478
    • Pigazzi, M.1    Manara, E.2    Baron, E.3
  • 131
    • 80051590849 scopus 로고    scopus 로고
    • Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice
    • Pramanik, D., Campbell, N. R., Karikari, C., et al. (2011). Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice. Mol. Cancer Ther. 10, 1470-1480.
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 1470-1480
    • Pramanik, D.1    Campbell, N.R.2    Karikari, C.3
  • 132
    • 78650459322 scopus 로고    scopus 로고
    • C/EBPa regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations
    • Pulikkan, J. A., Peramangalam, P. S., Dengler, V., et al. (2010). C/EBPa regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations. Blood 116, 5638-5649.
    • (2010) Blood , vol.116 , pp. 5638-5649
    • Pulikkan, J.A.1    Peramangalam, P.S.2    Dengler, V.3
  • 133
    • 77954958215 scopus 로고    scopus 로고
    • MicroRNA-34a per- turbsBlymphocytedevelopmentbyrepressingtheforkheadboxtranscription factor Foxp1
    • Rao, D. S., O'Connell, R. M., Chaudhuri, A. A., et al. (2010). MicroRNA-34a per- turbsBlymphocytedevelopmentbyrepressingtheforkheadboxtranscription factor Foxp1. Immunity 33, 48-59.
    • (2010) Immunity , vol.33 , pp. 48-59
    • Rao, D.S.1    O'Connell, R.M.2    Chaudhuri, A.A.3
  • 135
    • 80053039210 scopus 로고    scopus 로고
    • Mutations in the p53 tumor suppressor gene: Important milestones at the various steps of tumorigenesis
    • Rivlin, N., Brosh, R., Oren, M., et al. (2011). Mutations in the p53 tumor suppressor gene: important milestones at the various steps of tumorigenesis. Genes Cancer 2, 466-474.
    • (2011) Genes Cancer , vol.2 , pp. 466-474
    • Rivlin, N.1    Brosh, R.2    Oren, M.3
  • 136
    • 84897561550 scopus 로고    scopus 로고
    • IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
    • Rokavec, M., Öner, M. G., Li, H., et al. (2014). IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J. Clin. Invest. 124, 1853-1867.
    • (2014) J. Clin. Invest. , vol.124 , pp. 1853-1867
    • Rokavec, M.1    Öner, M.G.2    Li, H.3
  • 137
    • 78049339462 scopus 로고    scopus 로고
    • Circulating microRNAsasblood-based markersfor patients with primaryand metastatic breast cancer
    • Roth, C., Rack, B., Müller, V., et al. (2010). Circulating microRNAsasblood-based markersfor patients with primaryand metastatic breast cancer. BreastCancer Res. 12, R90.
    • (2010) BreastCancer Res. , vol.12
    • Roth, C.1    Rack, B.2    Müller, V.3
  • 138
    • 84866280242 scopus 로고    scopus 로고
    • Expression of miR-34 is lost in colon cancer whichcanbere- expressedbyanovelagent CDF
    • Roy, S., Levi, E., Majumdar, A. P., et al. (2012). Expression of miR-34 is lost in colon cancer whichcanbere-expressedbyanovelagent CDF. J. Hematol. Oncol. 5, 58.
    • (2012) J. Hematol. Oncol. , vol.5 , pp. 58
    • Roy, S.1    Levi, E.2    Majumdar, A.P.3
  • 139
    • 84859361521 scopus 로고    scopus 로고
    • MicroRNA-34a upre-gulation during seizure-induced neuronal death
    • Sano, T., Reynolds, J. P., Jimenez-Mateos, E. M., et al. (2012). MicroRNA-34a upre-gulation during seizure-induced neuronal death. Cell Death Dis. 3, e287.
    • (2012) Cell Death Dis. , vol.3
    • Sano, T.1    Reynolds, J.P.2    Jimenez-Mateos, E.M.3
  • 140
    • 84867987172 scopus 로고    scopus 로고
    • MicroRNA-34a affects the occurrence of laryngeal squamous cell carcinomaby targeting the antiapoptotic gene survi-vin
    • Shen, Z., Zhan, G., Ye, D., et al. (2012). MicroRNA-34a affects the occurrence of laryngeal squamous cell carcinomaby targeting the antiapoptotic gene survi-vin. Med. Oncol. 29, 2473-2480.
    • (2012) Med. Oncol. , vol.29 , pp. 2473-2480
    • Shen, Z.1    Zhan, G.2    Ye, D.3
  • 141
    • 84055184850 scopus 로고    scopus 로고
    • MiR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
    • Siemens, H., Jackstadt, R., Hunten, S., et al. (2011). miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle 10, 4256-4271.
    • (2011) Cell Cycle , vol.10 , pp. 4256-4271
    • Siemens, H.1    Jackstadt, R.2    Hunten, S.3
  • 142
    • 84884679127 scopus 로고    scopus 로고
    • Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness
    • Siemens, H., Jackstadt, R., Kaller, M., et al. (2013a). Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness. Oncotarget 4, 1399-1415.
    • (2013) Oncotarget , vol.4 , pp. 1399-1415
    • Siemens, H.1    Jackstadt, R.2    Kaller, M.3
  • 143
    • 84873373140 scopus 로고    scopus 로고
    • DetectionofmiR-34a promoter methylation in combination with elevated expression of c-Met and b-catenin predicts distant metastasis of colon cancer
    • Siemens, H., Neumann, J., Jackstadt, R., et al. (2013b). DetectionofmiR-34a promoter methylation in combination with elevated expression of c-Met and b-catenin predicts distant metastasis of colon cancer. Clin. Cancer Res. 19, 710-720.
    • (2013) Clin. Cancer Res. , vol.19 , pp. 710-720
    • Siemens, H.1    Neumann, J.2    Jackstadt, R.3
  • 144
    • 84858987120 scopus 로고    scopus 로고
    • MiR-34a repression in proneural malignantgliomasupregulatesexpressionofitstarget PDGFRA and promotes tumorigenesis
    • Silber, J., Jacobsen, A., Ozawa, T., et al. (2012). miR-34a repression in proneural malignantgliomasupregulatesexpressionofitstarget PDGFRA and promotes tumorigenesis. PLoS One 7, e33844.
    • (2012) PLoS One , vol.7
    • Silber, J.1    Jacobsen, A.2    Ozawa, T.3
  • 145
    • 84877291229 scopus 로고    scopus 로고
    • MiR-34 is maternally inherited in Drosophila melanogaster and Danio rerio
    • Soni, K., Choudhary, A., Patowary, A., et al. (2013). miR-34 is maternally inherited in Drosophila melanogaster and Danio rerio. Nucleic Acids Res. 41, 4470-4480.
    • (2013) Nucleic Acids Res. , vol.41 , pp. 4470-4480
    • Soni, K.1    Choudhary, A.2    Patowary, A.3
  • 146
    • 79957891891 scopus 로고    scopus 로고
    • Myc overexpression brings out unexpected antiapoptotic effects of miR-34a
    • Sotillo, E., Laver, T., Mellert, H., et al. (2011). Myc overexpression brings out unexpected antiapoptotic effects of miR-34a. Oncogene 30, 2587-2594.
    • (2011) Oncogene , vol.30 , pp. 2587-2594
    • Sotillo, E.1    Laver, T.2    Mellert, H.3
  • 147
    • 78650173364 scopus 로고    scopus 로고
    • Circulating microRNAs, possible indicators of progress of rat hepatocarcinogenesis from early stages
    • Sukata, T., Sumida, K., Kushida, M., et al. (2011). Circulating microRNAs, possible indicators of progress of rat hepatocarcinogenesis from early stages. Toxicol. Lett. 200, 46-52.
    • (2011) Toxicol. Lett. , vol.200 , pp. 46-52
    • Sukata, T.1    Sumida, K.2    Kushida, M.3
  • 148
    • 42049092138 scopus 로고    scopus 로고
    • Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest
    • Sun, F., Fu, H., Liu, Q., et al. (2008). Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest. FEBS Lett. 582, 1564-1568.
    • (2008) FEBS Lett. , vol.582 , pp. 1564-1568
    • Sun, F.1    Fu, H.2    Liu, Q.3
  • 149
    • 67749143728 scopus 로고    scopus 로고
    • Modulation of microRNA processing by p53
    • Suzuki, H. I., Yamagata, K., Sugimoto, K., et al. (2009). Modulation of microRNA processing by p53. Nature 460, 529-533.
    • (2009) Nature , vol.460 , pp. 529-533
    • Suzuki, H.I.1    Yamagata, K.2    Sugimoto, K.3
  • 150
    • 78649787634 scopus 로고    scopus 로고
    • Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect
    • Suzuki, H., Yamamoto, E., Nojima, M., et al. (2010). Methylation- associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect. Carcinogenesis 31, 2066-2073.
    • (2010) Carcinogenesis , vol.31 , pp. 2066-2073
    • Suzuki, H.1    Yamamoto, E.2    Nojima, M.3
  • 151
    • 84861567114 scopus 로고    scopus 로고
    • MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: Effect of statins on SIRT1 and microRNA-34a expression
    • Tabuchi, T., Satoh, M., Itoh, T., et al. (2012). MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression. Clin. Sci. 123, 161-171.
    • (2012) Clin. Sci. , vol.123 , pp. 161-171
    • Tabuchi, T.1    Satoh, M.2    Itoh, T.3
  • 154
    • 78951477589 scopus 로고    scopus 로고
    • MicroRNA-34aisapotenttumor suppressor molecule in vivo in neuroblastoma
    • Tivnan, A., Tracey, L., Buckley, P. G., et al. (2011). MicroRNA-34aisapotenttumor suppressor molecule in vivo in neuroblastoma. BMC Cancer 11, 33.
    • (2011) BMC Cancer , vol.11 , pp. 33
    • Tivnan, A.1    Tracey, L.2    Buckley, P.G.3
  • 155
    • 84895923572 scopus 로고    scopus 로고
    • SerummiR-200cisanovelprognos-tic and metastasis-predictive biomarker in patients with colorectal cancer
    • doi: 10. 1097/SLA. 0b013e3182a6909d
    • Toiyama, Y., Hur, K., Tanaka, K., et al. (2013). SerummiR- 200cisanovelprognos-tic and metastasis-predictive biomarker in patients with colorectal cancer. Ann. Surg. doi: 10. 1097/SLA. 0b013e3182a6909d.
    • (2013) Ann. Surg
    • Toiyama, Y.1    Hur, K.2    Tanaka, K.3
  • 156
    • 49249121155 scopus 로고    scopus 로고
    • Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer
    • Toyota, M., Suzuki, H., Sasaki, Y., et al. (2008). Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res. 68, 4123-4132.
    • (2008) Cancer Res. , vol.68 , pp. 4123-4132
    • Toyota, M.1    Suzuki, H.2    Sasaki, Y.3
  • 157
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • Tsai, J. H., Donaher, J. L., Murphy, D. A., et al. (2012). Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 22, 725-736.
    • (2012) Cancer Cell , vol.22 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3
  • 158
    • 84859163248 scopus 로고    scopus 로고
    • MiR-34achemosensitizes bladder cancer cells to cisplatin treatment regardless of p53-Rb pathway status
    • Vinall, R. L., Ripoll, A. Z., Wang, S., et al. (2012). MiR-34achemosensitizes bladder cancer cells to cisplatin treatment regardless of p53-Rb pathway status. Int. J. Cancer 130, 2526-2538.
    • (2012) Int. J. Cancer , vol.130 , pp. 2526-2538
    • Vinall, R.L.1    Ripoll, A.Z.2    Wang, S.3
  • 159
    • 0034676455 scopus 로고    scopus 로고
    • Surfingthe p53 network
    • Vogelstein, B., Lane, D., and Levine, A. J. (2000). Surfingthe p53 network. Nature 408, 307-310.
    • (2000) Nature , vol.408 , pp. 307-310
    • Vogelstein, B.1    Lane, D.2    Levine, A.J.3
  • 160
    • 79954455860 scopus 로고    scopus 로고
    • Frequent concomitant inactiva-tion of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cellcarcinomas and soft tissuesarco-mas
    • Vogt, M., Munding, J., Gruner, M., et al. (2011). Frequent concomitant inactiva-tion of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cellcarcinomas and soft tissuesarco-mas. Virchows Arch. 458, 313-322.
    • (2011) Virchows Arch. , vol.458 , pp. 313-322
    • Vogt, M.1    Munding, J.2    Gruner, M.3
  • 161
    • 84870597310 scopus 로고    scopus 로고
    • MicroRNA miR-34a regulates cytodiffer-entiation and targets multi-signaling pathways in human dental papilla cells
    • Wan, M., Gao, B., Sun, F., et al. (2012). microRNA miR-34a regulates cytodiffer-entiation and targets multi-signaling pathways in human dental papilla cells. PLoS One 7, e50090.
    • (2012) PLoS One , vol.7
    • Wan, M.1    Gao, B.2    Sun, F.3
  • 163
    • 70349558133 scopus 로고    scopus 로고
    • MiR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation
    • Wang, X., Liu, P., Zhu, H., et al. (2009). miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation. Brain Res. Bull. 80, 268-273.
    • (2009) Brain Res. Bull. , vol.80 , pp. 268-273
    • Wang, X.1    Liu, P.2    Zhu, H.3
  • 164
    • 82755162444 scopus 로고    scopus 로고
    • Altered profile of seminal plasma microRNAs in the molecular diagnosis of male infertility
    • Wang, C., Yang, C., Chen, X., et al. (2011a). Altered profile of seminal plasma microRNAs in the molecular diagnosis of male infertility. Clin. Chem. 57, 1722-1731.
    • (2011) Clin. Chem. , vol.57 , pp. 1722-1731
    • Wang, C.1    Yang, C.2    Chen, X.3
  • 165
    • 79952331586 scopus 로고    scopus 로고
    • DNA hypermethylation of microRNA-34b/c has prognostic value for stage i non-small cell lung cancer
    • Wang, Z., Chen, Z., Gao, Y., et al. (2011b). DNA hypermethylation of microRNA-34b/c has prognostic value for stage I non-small cell lung cancer. Cancer Biol. Ther. 11, 490-496.
    • (2011) Cancer Biol. Ther. , vol.11 , pp. 490-496
    • Wang, Z.1    Chen, Z.2    Gao, Y.3
  • 166
    • 84873019665 scopus 로고    scopus 로고
    • Effects of low temperatures on proliferation-related signaling pathways in the hippocampus after traumatic brain injury
    • Wang, Y., Guo, F., Pan, C., et al. (2012). Effects of low temperatures on proliferation-related signaling pathways in the hippocampus after traumatic brain injury. Exp. Biol. Med. 237, 1424-1432.
    • (2012) Exp. Biol. Med. , vol.237 , pp. 1424-1432
    • Wang, Y.1    Guo, F.2    Pan, C.3
  • 167
    • 84878874617 scopus 로고    scopus 로고
    • MiR-34b regulates multiciliogenesis during organ formation in zebrafish
    • Wang, L., Fu, C., Fan, H., et al. (2013a). miR-34b regulates multiciliogenesis during organ formation in zebrafish. Development 140, 2755-2764.
    • (2013) Development , vol.140 , pp. 2755-2764
    • Wang, L.1    Fu, C.2    Fan, H.3
  • 168
    • 84881319995 scopus 로고    scopus 로고
    • Functional roleofmiR-34 familyinhuman cancer
    • Wang, R., Ma, J., Wu, Q., et al. (2013b). Functional roleofmiR-34 familyinhuman cancer. Curr. Drug Targets 14, 1185-1191.
    • (2013) Curr. Drug Targets , vol.14 , pp. 1185-1191
    • Wang, R.1    Ma, J.2    Wu, Q.3
  • 169
    • 84879736644 scopus 로고    scopus 로고
    • Mutant p53-R273H gains new func-tioninsustained activationofEGFR signaling viasuppressing miR-27aexpres-sion
    • Wang, W., Cheng, B., Miao, L., et al. (2013c). Mutant p53-R273H gains new func-tioninsustained activationofEGFR signaling viasuppressing miR-27aexpres-sion. Cell Death Dis. 4, e574.
    • (2013) Cell Death Dis. , vol.4
    • Wang, W.1    Cheng, B.2    Miao, L.3
  • 170
    • 51349157982 scopus 로고    scopus 로고
    • The MYCN oncogene is a direct target of miR-34a
    • Wei, J. S., Song, Y. K., Durinck, S., et al. (2008). The MYCN oncogene is a direct target of miR-34a. Oncogene 27, 5204-5213.
    • (2008) Oncogene , vol.27 , pp. 5204-5213
    • Wei, J.S.1    Song, Y.K.2    Durinck, S.3
  • 171
    • 84862624955 scopus 로고    scopus 로고
    • MiR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2
    • Wei, J., Shi, Y., Zheng, L., et al. (2012). miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2. J. Cell Biol. 197, 509-521.
    • (2012) J. Cell Biol. , vol.197 , pp. 509-521
    • Wei, J.1    Shi, Y.2    Zheng, L.3
  • 172
    • 34249812122 scopus 로고    scopus 로고
    • MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
    • DOI 10.1038/sj.onc.1210293, PII 1210293
    • Welch, C., Chen, Y., and Stallings, R. L. (2007). MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene 26, 5017-5022. (Pubitemid 47172643)
    • (2007) Oncogene , vol.26 , Issue.34 , pp. 5017-5022
    • Welch, C.1    Chen, Y.2    Stallings, R.L.3
  • 173
    • 77955022405 scopus 로고    scopus 로고
    • Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34
    • Wiggins, J. F., Ruffino, L., Kelnar, K., et al. (2010). Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34. Cancer Res. 70, 5923-5930.
    • (2010) Cancer Res. , vol.70 , pp. 5923-5930
    • Wiggins, J.F.1    Ruffino, L.2    Kelnar, K.3
  • 174
    • 84877267433 scopus 로고    scopus 로고
    • MiR-34a sets the 'sweet spot' for notch in colorectal cancer stem cells
    • Winton, D. J. (2013). miR-34a sets the 'sweet spot' for notch in colorectal cancer stem cells. Cell Stem Cell 12, 499-501.
    • (2013) Cell Stem Cell , vol.12 , pp. 499-501
    • Winton, D.J.1
  • 175
    • 82355171192 scopus 로고    scopus 로고
    • ′UTR of HNF4A mRNA reveals an interplay of regulatory elements including miRNA target sites
    • ′UTR of HNF4A mRNA reveals an interplay of regulatory elements including miRNA target sites. PLoS One 6, e27438.
    • (2011) PLoS One , vol.6
    • Wirsing, A.1    Senkel, S.2    Klein-Hitpass, L.3
  • 176
    • 84863230238 scopus 로고    scopus 로고
    • MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1
    • Wu, J., Wu, G., Lv, L., et al. (2012). MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1. Carcinogenesis 33, 519-528.
    • (2012) Carcinogenesis , vol.33 , pp. 519-528
    • Wu, J.1    Wu, G.2    Lv, L.3
  • 177
    • 84877926074 scopus 로고    scopus 로고
    • Regulation of microtubule-associated protein tau (MAPT) by miR-34c-5p determines the chemo-sensitivity of gastric cancer to paclitaxel
    • Wu, H., Huang, M., Lu, M., et al. (2013). Regulation of microtubule-associated protein tau (MAPT) by miR-34c-5p determines the chemo-sensitivity of gastric cancer to paclitaxel. Cancer Chemother. Pharmacol. 71, 1159-1171.
    • (2013) Cancer Chemother. Pharmacol. , vol.71 , pp. 1159-1171
    • Wu, H.1    Huang, M.2    Lu, M.3
  • 178
    • 84878196578 scopus 로고    scopus 로고
    • Genistein inhibits cell growth and induces apoptosis through up-regulation of miR-34a in pancreatic cancer cells
    • Xia, J., Duan, Q., Ahmad, A., et al. (2012). Genistein inhibits cell growth and induces apoptosis through up-regulation of miR-34a in pancreatic cancer cells. Curr. Drug Targets 13, 1750-1756.
    • (2012) Curr. Drug Targets , vol.13 , pp. 1750-1756
    • Xia, J.1    Duan, Q.2    Ahmad, A.3
  • 179
    • 84861623180 scopus 로고    scopus 로고
    • Micro-RNA-34a contributes to the impaired function of bone marrow-derived mononuclear cells from patients with cardiovascular disease
    • Xu, Q., Seeger, F. H., Castillo, J., et al. (2012). Micro-RNA-34a contributes to the impaired function of bone marrow-derived mononuclear cells from patients with cardiovascular disease. J. Am. Coll. Cardiol. 59, 2107-2117.
    • (2012) J. Am. Coll. Cardiol. , vol.59 , pp. 2107-2117
    • Xu, Q.1    Seeger, F.H.2    Castillo, J.3
  • 180
    • 84879448114 scopus 로고    scopus 로고
    • Associationsbetween circulating microRNAs (miR-21, miR-34a, miR-122 and miR-451) and non-alcoholic fatty liver
    • Yamada, H., Suzuki, K., Ichino, N., et al. (2013). Associationsbetween circulating microRNAs (miR-21, miR-34a, miR-122 and miR-451) and non-alcoholic fatty liver. Clin. Chim. Acta 424, 99-103.
    • (2013) Clin. Chim. Acta , vol.424 , pp. 99-103
    • Yamada, H.1    Suzuki, K.2    Ichino, N.3
  • 182
    • 84858632494 scopus 로고    scopus 로고
    • MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo
    • Yan, K., Gao, J., Yang, T., et al. (2012). MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo. PLoS One 7, e33778.
    • (2012) PLoS One , vol.7
    • Yan, K.1    Gao, J.2    Yang, T.3
  • 183
    • 84866018690 scopus 로고    scopus 로고
    • TGF-b-miR-34a-CCL22 signaling-induced Tregcell recruitmentpromotesvenousmetastasesofHBV-positive hepatocel-lular carcinoma
    • Yang, P., Li, Q.-J., Feng, Y., et al. (2012). TGF-b-miR-34a-CCL22 signaling-induced Tregcell recruitmentpromotesvenousmetastasesofHBV-positive hepatocel-lular carcinoma. Cancer Cell 22, 291-303.
    • (2012) Cancer Cell , vol.22 , pp. 291-303
    • Yang, P.1    Li, Q.-J.2    Feng, Y.3
  • 184
    • 84872616169 scopus 로고    scopus 로고
    • MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9
    • Yang, J., Chen, D., He, Y., et al. (2013a). MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9. Age 35, 11-22.
    • (2013) Age , vol.35 , pp. 11-22
    • Yang, J.1    Chen, D.2    He, Y.3
  • 185
    • 84883742665 scopus 로고    scopus 로고
    • MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1
    • Yang, S., Li, Y., Gao, J., et al. (2013b). MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1. Oncogene 32, 4294-4303.
    • (2013) Oncogene , vol.32 , pp. 4294-4303
    • Yang, S.1    Li, Y.2    Gao, J.3
  • 186
    • 84876939170 scopus 로고    scopus 로고
    • The long and short of microRNA
    • Yates, L. A., Norbury, C. J., and Gilbert, R. J. (2013). The long and short of microRNA. Cell 153, 516-519.
    • (2013) Cell , vol.153 , pp. 516-519
    • Yates, L.A.1    Norbury, C.J.2    Gilbert, R.J.3
  • 187
    • 84855279252 scopus 로고    scopus 로고
    • MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cells
    • Yu, F., Jiao, Y., Zhu, Y., et al. (2012). MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cells. J. Biol. Chem. 287, 465-473.
    • (2012) J. Biol. Chem. , vol.287 , pp. 465-473
    • Yu, F.1    Jiao, Y.2    Zhu, Y.3
  • 188
    • 84890521618 scopus 로고    scopus 로고
    • MiR-34c enhances mouse spermatogonial stem cells differentiation by targeting Nanos2
    • Yu, M., Mu, H., Niu, Z., et al. (2014). miR-34c enhances mouse spermatogonial stem cells differentiation by targeting Nanos2. J. Cell. Biochem. 115, 232-242.
    • (2014) J. Cell. Biochem. , vol.115 , pp. 232-242
    • Yu, M.1    Mu, H.2    Niu, Z.3
  • 189
    • 84870653895 scopus 로고    scopus 로고
    • MIR-34cregulatesmouse embryonic stem cells differentiation into male germ-like cells through RARg
    • Zhang, S., Yu, M., Liu, C., et al. (2012). MIR-34cregulatesmouse embryonic stem cells differentiation into male germ-like cells through RARg. Cell Biochem. Funct. 30, 623-632.
    • (2012) Cell Biochem. Funct. , vol.30 , pp. 623-632
    • Zhang, S.1    Yu, M.2    Liu, C.3
  • 190
    • 77953457652 scopus 로고    scopus 로고
    • MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1
    • Zhao, T., Li, J., andChen, A. F. (2010). MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1. Am. J. Physiol. Endocrinol. Metab. 299, E110-E116.
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.299
    • Zhao, T.1    Li Andchen J, A.F.2
  • 191
    • 84888597813 scopus 로고    scopus 로고
    • MicroRNA-34a suppresses cell proliferation by targeting LMTK3 in human breast cancer MCF-7 cell line
    • Zhao, G., Guo, J., Li, D., et al. (2013a). MicroRNA-34a suppresses cell proliferation by targeting LMTK3 in human breast cancer MCF-7 cell line. DNA Cell Biol. 32, 699-707.
    • (2013) DNA Cell Biol. , vol.32 , pp. 699-707
    • Zhao, G.1    Guo, J.2    Li, D.3
  • 192
    • 84872810157 scopus 로고    scopus 로고
    • MiR-34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44
    • Zhao, H., Ma, B., Wang, Y., et al. (2013b). miR-34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44. Oncol. Rep. 29, 1027-1036.
    • (2013) Oncol. Rep. , vol.29 , pp. 1027-1036
    • Zhao, H.1    Ma, B.2    Wang, Y.3
  • 193
    • 80054935981 scopus 로고    scopus 로고
    • MicroRNA-34c is a novel target to treat dementias
    • Zovoilis, A., Agbemenyah, H. Y., Agis-Balboa, R. C., et al. (2011). microRNA-34c is a novel target to treat dementias. EMBO J. 30, 4299-4308.
    • (2011) EMBO J. , vol.30 , pp. 4299-4308
    • Zovoilis, A.1    Agbemenyah, H.Y.2    Agis-Balboa, R.C.3


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