miR-34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44

Oncology Reports

Volumn 29, Issue 3, 2013, Pages 1027-1036

  Zhao, Haien ^a,b   Ma, Baoan ^a   Wang, Yucai ^a   Han, Tao ^a   Zheng, Lianhe ^a   Sun, Cong ^a   Liu, Tao ^a   Zhang, Yinglong ^a   Qiu, Xiuchun ^a   Fan, Qingyu ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b XI'AN RESEARCH INSTITUTE OF HIGH TECHNOLOGY   (China)

Author keywords

Cancer stem cell; CD44; Invasion; Migration; MiR 34a; Osteosarcoma

Indexed keywords

HERMES ANTIGEN; MICRORNA 34A;

ANTIGEN EXPRESSION; ARTICLE; CANCER CELL CULTURE; CELL INVASION; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INHIBITION KINETICS; METASTASIS INHIBITION; METASTASIS POTENTIAL; OSTEOSARCOMA; OSTEOSARCOMA CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTIGENS, CD44; APOPTOSIS; BONE NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICRORNAS; NEOPLASM INVASIVENESS; OSTEOSARCOMA; RNA INTERFERENCE;

EID: 84872810157     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2234     Document Type: Article

References (55)

1. Bentzen SM, Poulsen HS, Kaae S, Jensen OM, Johansen H, Mouridsen HT, Daugaard S and Arnoldi C: Prognostic factors in osteosarcomas, a regression analysis. Cancer 62: 194-202, 1988.
2. Davis AM, Bell RS and Goodwin PJ: Prognostic factors in osteo-sarcoma: a critical review. J Clin Oncol 12: 423-431, 1994. (Pubitemid 24056419)
3. Mankin HJ, Hornicek FJ, Rosenberg AE, Harmon DC and Gebhardt MC: Survival data for 648 patients with osteosarcoma treated at one institution. Clin Orthop Relat Res 429: 286-291, 2004. (Pubitemid 39579224)
4. Filipowicz W, Bhattacharyya SN and Sonenberg N: Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 9: 102-114, 2008.
5. Medina PP and Slack FJ: microRNAs and cancer: an overview. Cell Cycle 7: 2485-2492, 2008.
6. Pillai RS, Bhattacharyya SN and Filipowiczm W: Repression of protein synthesis by miRNAs: how many mechanisms? Trends Cell Biol 17: 118-126, 2007. (Pubitemid 46357525)
7. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
8. Zhang B, Pan X, Cobb GP and Anderson TA: microRNAs as oncogenes and tumor suppressors. Dev Biol 302: 1-12, 2007. (Pubitemid 46096921)
9. Bartel DP: MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233, 2009.
10. Caldas C and Brenton JD: Sizing up miRNAs as cancer genes. Nat Med 11: 712-714, 2005. (Pubitemid 41021196)
11. He L, He X, Lim LP, de Stanchina E, Xuan Z, et al: A microRNA component of the p53 tumour suppressor network. Nature 447: 1130-1134, 2007. (Pubitemid 47014436)
12. Raver-Shapira N, Marciano E, Meiri E, Spector Y, Rosenfield N, et al: Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell 26: 731-743, 2007. (Pubitemid 46856247)
13. Welch C, Chen Y and Stallings RL: MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuro-blastoma cells. Oncogene 26: 5017-5022, 2007. (Pubitemid 47172643)
14. Lewis BP, Burge CB and Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120: 15-20, 2005. (Pubitemid 40094598)
15. Sun F, Fu H, Liu Q, Tie Y, Zhu J, et al: Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest. FEBS Lett 582: 1564-1568, 2005.
16. Wei JS, Song YK, Durinck S, Chen QR, Cheuk AT, et al: The MYCN oncogene is a direct target of miR-34a. Oncogene 27: 5204-5213, 2008.
17. Yamakuchi M, Ferlito M and Lowenstein CJ: miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci USA 105: 13421-13426, 2008.
18. Chen X, Yang TT, Wang W, Sun HH, Ma BA, Li CX, Ma Q, Yu Z and Fan QY: Establishment and characterization of human osteosarcoma cell lines with different pulmonary metastatic potentials. Cytotechnology 61: 37-44, 2009.
19. He C, Xiong J, Xu X, Lu W, Liu L, Xiao D and Wang D: Functional elucidation of MiR-34 in osteosarcoma cells and primary tumor samples. Biochem Biophys Res Commun 388: 35-40, 2009.
20. Guo Y, Li S, Qu J, Wang S, Dang Y, et al: MiR-34a inhibits lymphatic metastasis potential of mouse hepatoma cells. Mol Cell Biochem 354: 275-282, 2011.
21. Liu C, Kelnar K, Liu B, Chen X, Calhoun-Davis T, et al: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med 17: 211-215, 2011.
22. Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP and Burge CB: Prediction of mammalian microRNA targets. Cell 115: 787-798, 2003. (Pubitemid 38058492)
23. Krek A, Grün D, Poy MN, Wolf R, Rosenberg L, et al: Combinatorial microRNA target predictions. Nat Genet 37: 495-500, 2005. (Pubitemid 40617277)
24. John B, Enright AJ, Aravin A, Tuschl T, Sander C and Marks DS: Human MicroRNA targets. PLoS Biol 2: e264, 2004.
25. Coltella N, Manara MC, Cerisano V, Trusolino L, et al: Role of the MET/HGF receptor in proliferation and invasive behavior of osteosarcoma. FASEB J 17: 1162-1164, 2003.
26. Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, et al: Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451: 147-152, 2008.
27. Leite KR, Sousa-Canavez JM, Reis ST, Tomiyama AH, Camara-Lopes LH, Sañudo A, Antunes AA and Srougi M: Change in expression of miR-let7c, miR-100, and miR-218 from high grade localized prostate cancer to metastasis. Urol Oncol 29: 265-269, 2009.
28. Mazar J, DeBlasio D, Govindarajan SS, Zhang S and Perera RJ: Epigenetic regulation of microRNA-375 and its role in melanoma development in humans. FEBS Lett 585: 2467-2476, 2011.
29. Kumar MS, Lu J, Mercer KL, Golub TR and Jacks T: Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet 39: 673-677, 2007. (Pubitemid 46676103)
30. Tan S, Li R, Ding K, Lobie PE and Zhu T: miR-198 inhibits migration and invasion of hepatocellular carcinoma cells by targeting the HGF/c-MET pathway. FEBS Lett 585: 2229-2234, 2011.
31. Wu L, Cai C, Wang X, Liu M, Li X and Tang H: MicroRNA-142-3p, a new regulator of RAC1, suppresses the migration and invasion of hepatocellular carcinoma cells. FEBS Lett 585: 1322-1330, 2011.
32. Cozzolino AM, Pedace L, Castori M, De Simone P, Preziosi N, et al: Analysis of the miR-34a locus in 62 patients with familial cutaneous melanoma negative for CDKN2A/CDK4 screening. Fam Cancer 11: 201-208, 2012.
33. Yan D, Zhou X, Chen X, Hu D, Dong X, et al: MicroRNA-34a Inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met. Invest Ophthalmol Vis Sci 50: 1559-1565, 2009.
34. Zhao T, Li J and Chen AF: MicroRNA-34a induces endothe-lial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1. Am J Physiol Endocrinol Metab 299: E110-E116, 2010.
35. Pang RT, Leung CO, Ye TM, Liu W, Chiu PC, et al: MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells. Carcinogenesis 31: 1037-1044, 2010.
36. Doench JG and Sharp PA: Specificity of microRNA target selection in translational repression. Genes Dev 18: 504-511, 2004. (Pubitemid 38372808)
37. Aruffo A, Stamenkovic I, Melnick M, Underhill CB and Seed B: CD44 is the principal cell surface receptor for hyaluronate. Cell 61: 1303-1313, 1990.
38. Ponta H, Sherman L and Herrlich PA: CD44: from adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol 4: 33-45, 2003. (Pubitemid 36077255)
39. Marhaba R and Zöller M: CD44 in cancer progression: adhesion, migration and growth regulation. J Mol Histol 35: 211-231, 2004. (Pubitemid 40585308)
40. Gotte M and Yip GW: Heparanase, hyaluronan, and CD44 in cancers: a breast carcinoma perspective. Cancer Res 66: 10233-10237, 2006. (Pubitemid 44799736)
41. Olsson E, Honeth G, Bendahl PO, Saal LH, Gruvberger-Saal S, Ringnér M, et al: CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers. BMC Cancer 11: 418, 2011.
42. Heyse TJ, Malcherczyk D, Moll R, Timmesfeld N, Wapelhorst J, et al: CD44: survival and metastasis in chondrosarcoma. Osteoarthritis Cartilage 18: 849-856, 2010.
43. high metastatic subset in HCT116 colon cancer cells. Clin Exp Metastasis 28: 751-763, 2011.
44. + gastric cancer stem cells. J Cancer Res Clin Oncol 137: 1679-1686, 2011.
45. Takaishi S, Okumura T, Tu S, Wang SS, Shibata W, et al: Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells 27: 1006-1020, 2009.
46. Afify A, Purnell P and Nguyen L: Role of CD44s and CD44v6 on human breast cancer cell adhesion, migration, and invasion. Exp Mol Pathol 86: 95-100, 2009.
47. Kim HS, Park YB, Oh JH, Jeong J, Kim CJ and Lee SH: Expression of CD44 isoforms correlates with the metastatic potential of osteosarcoma. Clin Orthop Relat Res 396: 184-190, 2002. (Pubitemid 34207970)
48. Visvader JE and Lindeman GJ: Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8: 755-768, 2008.
49. Chen R, Nishimura MC, Bumbaca SM, et al: A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. Cancer Cell 17: 362-375, 2010.
50. Jin L, Hope KJ, Zhai Q, Smadja-Joffe F and Dick JE: Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med 12: 1167-1174, 2006. (Pubitemid 44527352)
51. Ji Q, Hao X, Zhang M, Tang W, Yang M, et al: MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLoS One 4: e6816, 2009.
52. Wiggins JF, Ruffino L, Kelnar K, Omotola M, Patrawala L, et al: Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34. Cancer Res 70: 5923-5930, 2010.
53. Huang N, Lin J, Ruan J, Su N, Qing R, Liu F, He B, Lv C, Zheng D and Luo R: MiR-219-5p inhibits hepatocellular carcinoma cell proliferation by targeting glypican-3. FEBS Lett 586: 884-891, 2012.
54. Kang HW, Wang F, Wei Q, Zhao YF, Liu M, Li X and Tang H: miR-20a promotes migration and invasion by regulating TNKS2 in human cervical cancer cells. FEBS Lett 586: 897-904, 2012.
55. Wu L, Li H, Jia CY, Cheng W, Yu M, Peng M, Zhu Y, Zhao Q, Dong YW, Shao K, Wu A and Wu XZ: MicroRNA-223 regulates FOXO1 expression and cell proliferation. FEBS Lett 586: 1038-1043, 2012.