Down-regulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance

Arthritis and Rheumatism

Volumn 64, Issue 6, 2012, Pages 1771-1779

  Niederer, Fabienne ^a   Trenkmann, Michelle ^a   Ospelt, Caroline ^a   Karouzakis, Emmanuel ^a   Neidhart, Michel ^a   Stanczyk, Joanna ^a   Kolling, Christoph ^b   Gay, Renate E ^a   Detmar, Michael ^c   Gay, Steffen ^a   Jüngel, Astrid ^a   Kyburz, Diego ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b SCHULTHESS CLINIC   (Switzerland)

^c ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; BISULFITE; FAS LIGAND; INTERLEUKIN 1BETA; MICRORNA 34A; MICRORNA 34B; MICRORNA 34C; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FIBROBLAST; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; IMMUNOHISTOCHEMISTRY; METHYLATION; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; RESTRICTION MAPPING; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIOCYTE;

ANOXIA; APOPTOSIS; ARTHRITIS, RHEUMATOID; AZACITIDINE; CELLS, CULTURED; DOWN-REGULATION; FIBROBLASTS; HUMANS; INTERLEUKIN-1BETA; MICRORNAS; SYNOVIAL MEMBRANE; TUMOR NECROSIS FACTOR-ALPHA; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84857887315     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.34334     Document Type: Article

References (35)

1. Karouzakis E, Neidhart M, Gay RE, Gay S,. Molecular and cellular basis of rheumatoid joint destruction. Immunol Lett 2006; 106: 8-13.
2. Ospelt C, Brentano F, Rengel Y, Stanczyk J, Kolling C, Tak PP, et al. Overexpression of Toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis. Arthritis Rheum 2008; 58: 3684-92.
3. Korb A, Pavenstadt H, Pap T,. Cell death in rheumatoid arthritis. Apoptosis 2009; 14: 447-54.
4. Pundt N, Peters MA, Wunrau C, Strietholt S, Fehrmann C, Neugebauer K, et al. Susceptibility of rheumatoid arthritis synovial fibroblasts to FasL- and TRAIL-induced apoptosis is cell cycle-dependent. Arthritis Res Ther 2009; 11: R16.
5. Bartok B, Firestein GS,. Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev 2010; 233: 233-55.
6. Meinecke I, Cinski A, Baier A, Peters MA, Dankbar B, Wille A, et al. Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts. Proc Natl Acad Sci U S A 2007; 104: 5073-8.
7. Palao G, Santiago B, Galindo M, Rullas J, Alcami J, Ramirez JC, et al. Fas activation of a proinflammatory program in rheumatoid synoviocytes and its regulation by FLIP and caspase 8 signaling. Arthritis Rheum 2006; 54: 1473-81.
8. Liu H, Eksarko P, Temkin V, Haines GK III, Perlman H, Koch AE, et al. Mcl-1 is essential for the survival of synovial fibroblasts in rheumatoid arthritis. J Immunol 2005; 175: 8337-45.
9. Kloosterman WP, Plasterk RH,. The diverse functions of microRNAs in animal development and disease. Dev Cell 2006; 11: 441-50.
10. Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, et al. Altered expression of microRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum 2008; 58: 1001-9.
11. Takeshita D, Zenno S, Lee WC, Nagata K, Saigo K, Tanokura M,. Homodimeric structure and double-stranded RNA cleavage activity of the C-terminal RNase III domain of human dicer. J Mol Biol 2007; 374: 106-20.
12. Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, et al. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 2007; 26: 745-52.
13. He L, He X, Lim LP, de Stanchina E, Xuan Z, Liang Y, et al. A microRNA component of the p53 tumour suppressor network. Nature 2007; 447: 1130-4.
14. Lodygin D, Tarasov V, Epanchintsev A, Berking C, Knyazeva T, Korner H, et al. Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer. Cell Cycle 2008; 7: 2591-600.
15. Sotillo E, Laver T, Mellert H, Schelter JM, Cleary MA, McMahon S, et al. Myc overexpression brings out unexpected antiapoptotic effects of miR-34a. Oncogene 2011; 30: 2587-94.
16. Bhatt K, Zhou L, Mi QS, Huang S, She JX, Dong Z,. MicroRNA-34a is induced via p53 during cisplatin nephrotoxicity and contributes to cell survival. Mol Med 2010; 16: 409-16.
17. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
18. T method. Nat Protoc 2008; 3: 1101-8.
19. Distler JH, Wenger RH, Gassmann M, Kurowska M, Hirth A, Gay S, et al. Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis [review]. Arthritis Rheum 2004; 50: 10-23.
20. Chim CS, Wong KY, Qi Y, Loong F, Lam WL, Wong LG, et al. Epigenetic inactivation of the miR-34a in hematological malignancies. Carcinogenesis 2010; 31: 745-50.
21. Karouzakis E, Gay RE, Michel BA, Gay S, Neidhart M,. DNA hypomethylation in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 2009; 60: 3613-22.
22. Dharmapatni AA, Smith MD, Findlay DM, Holding CA, Evdokiou A, Ahern MJ, et al. Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium. Arthritis Res Ther 2009; 11: R13.
23. Mudduluru G, Ceppi P, Kumarswamy R, Scagliotti GV, Papotti M, Allgayer H,. Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer. Oncogene 2011; 30: 2888-99.
24. Yamakuchi M, Ferlito M, Lowenstein CJ,. miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A 2008; 105: 13421-6.
25. Dogar AM, Towbin H, Hall J,. Suppression of latent transforming growth factor (TGF)-β1 restores growth inhibitory TGF-β signaling through microRNAs. J Biol Chem 2011; 286: 16447-58.
26. Ro S, Park C, Young D, Sanders KM, Yan W,. Tissue-dependent paired expression of miRNAs. Nucleic Acids Res 2007; 35: 5944-53.
27. Okamura K, Phillips MD, Tyler DM, Duan H, Chou YT, Lai EC,. The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolution. Nat Struct Mol Biol 2008; 15: 354-63.
28. Goparaju CM, Blasberg JD, Volinia S, Palatini J, Ivanov S, Donington JS, et al. Onconase mediated NFKβ downregulation in malignant pleural mesothelioma. Oncogene 2011: 30: 2767-77.
29. Vaucheret H, Vazquez F, Crete P, Bartel DP,. The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development. Genes Dev 2004; 18: 1187-97.
30. Zhou H, Huang X, Cui H, Luo X, Tang Y, Chen S, et al. miR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells. Blood 2010; 116: 5885-94.
31. Hunter AM, LaCasse EC, Korneluk RG,. The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis 2007; 12: 1543-68.
32. Damgaard RB, Gyrd-Hansen M,. Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity. Discov Med 2011; 11: 221-31.
33. Lopez J, Meier P,. To fight or die-inhibitor of apoptosis proteins at the crossroad of innate immunity and death. Curr Opin Cell Biol 2010; 22: 872-81.
34. Smolewska E, Stanczyk J, Robak T, Smolewski P,. Inhibited apoptosis of synovial fluid lymphocytes in children with juvenile idiopathic arthritis is associated with increased expression of myeloid cell leukemia 1 and XIAP proteins. J Rheumatol 2006; 33: 1684-90.
35. Carter BZ, Milella M, Tsao T, McQueen T, Schober WD, Hu W, et al. Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia. Leukemia 2003; 17: 2081-9.