-
1
-
-
0036674617
-
Live or let die: the cell's response to p53
-
Vousden K.H., Lu X. Live or let die: the cell's response to p53. Nat. Rev. Cancer 2002, 2:594-604.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
2
-
-
33646807832
-
The p53 pathway: what questions remain to be explored?
-
Levine A.J., Hu W., Feng Z. The p53 pathway: what questions remain to be explored?. Cell Death Differ. 2006, 13:1027-1036.
-
(2006)
Cell Death Differ.
, vol.13
, pp. 1027-1036
-
-
Levine, A.J.1
Hu, W.2
Feng, Z.3
-
4
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
Bensaad K., Tsuruta A., Selak M.A., Vidal M.N., Nakano K., Bartrons R., Gottlieb E., Vousden K.H. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 2006, 126:107-120.
-
(2006)
Cell
, vol.126
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.4
Nakano, K.5
Bartrons, R.6
Gottlieb, E.7
Vousden, K.H.8
-
5
-
-
33745149291
-
P53 regulates mitochondrial respiration
-
Matoba S., Kang J.G., Patino W.D., Wragg A., Boehm M., Gavrilova O., Hurley P.J., Bunz F., Hwang P.M. P53 regulates mitochondrial respiration. Science 2006, 312:1650-1653.
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
Hurley, P.J.7
Bunz, F.8
Hwang, P.M.9
-
6
-
-
77952212178
-
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
-
Hu W., Zhang C., Wu R., Sun Y., Levine A., Feng Z. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc. Natl. Acad. Sci. USA 2010, 107:7455-74560.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 7455-74560
-
-
Hu, W.1
Zhang, C.2
Wu, R.3
Sun, Y.4
Levine, A.5
Feng, Z.6
-
7
-
-
70449093664
-
GAMT a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress
-
Ide T., Brown-Endres L., Chu K., Ongusaha P.P., Ohtsuka T., El-Deiry W.S., Aaronson S.A., Lee S.W. GAMT a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress. Mol. Cell 2009, 36:379-392.
-
(2009)
Mol. Cell
, vol.36
, pp. 379-392
-
-
Ide, T.1
Brown-Endres, L.2
Chu, K.3
Ongusaha, P.P.4
Ohtsuka, T.5
El-Deiry, W.S.6
Aaronson, S.A.7
Lee, S.W.8
-
8
-
-
34249822779
-
Transcriptional activation of miR-34a contributes to p53-mediated apoptosis
-
Raver-Shapira N., Marciano E., Meiri E., Spector Y., Rosenfeld N., Moskovits N., Bentwich Z., Oren M. Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol. Cell 2007, 26:731-743.
-
(2007)
Mol. Cell
, vol.26
, pp. 731-743
-
-
Raver-Shapira, N.1
Marciano, E.2
Meiri, E.3
Spector, Y.4
Rosenfeld, N.5
Moskovits, N.6
Bentwich, Z.7
Oren, M.8
-
9
-
-
34249817549
-
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
-
Chang T.C., Wentzel E.A., Kent O.A., Ramachandran K., Mullendore M., Lee K.H., Feldmann G., Yamakuchi M., Ferlito M., Lowenstein C.J., Arking D.E., Beer M.A., Maitra A., Mendell J.T. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol. Cell 2007, 26:745-752.
-
(2007)
Mol. Cell
, vol.26
, pp. 745-752
-
-
Chang, T.C.1
Wentzel, E.A.2
Kent, O.A.3
Ramachandran, K.4
Mullendore, M.5
Lee, K.H.6
Feldmann, G.7
Yamakuchi, M.8
Ferlito, M.9
Lowenstein, C.J.10
Arking, D.E.11
Beer, M.A.12
Maitra, A.13
Mendell, J.T.14
-
10
-
-
34250851115
-
A microRNA component of the p53 tumour suppressor network
-
He L., He X., Lim L.P., De Stanchina E., Xuan Z., Liang Y., Xue W., Zender L., Magnus J., Ridzon D., Jackson A.L., Linsley P.S., Chen C., Lowe S.W., Cleary M.A., Hannon G.J. A microRNA component of the p53 tumour suppressor network. Nature 2007, 447:1130-1134.
-
(2007)
Nature
, vol.447
, pp. 1130-1134
-
-
He, L.1
He, X.2
Lim, L.P.3
De Stanchina, E.4
Xuan, Z.5
Liang, Y.6
Xue, W.7
Zender, L.8
Magnus, J.9
Ridzon, D.10
Jackson, A.L.11
Linsley, P.S.12
Chen, C.13
Lowe, S.W.14
Cleary, M.A.15
Hannon, G.J.16
-
11
-
-
35748961986
-
P53 enters the microRNA world
-
Hermeking H. P53 enters the microRNA world. Cancer Cell 2007, 12:414-418.
-
(2007)
Cancer Cell
, vol.12
, pp. 414-418
-
-
Hermeking, H.1
-
12
-
-
0016823448
-
IMP dehydrogenase, an enzyme linked with proliferation and malignancy
-
Jackson R.C., Weber G., Morris H.P. IMP dehydrogenase, an enzyme linked with proliferation and malignancy. Nature 1975, 256:331-333.
-
(1975)
Nature
, vol.256
, pp. 331-333
-
-
Jackson, R.C.1
Weber, G.2
Morris, H.P.3
-
13
-
-
0032775732
-
Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis
-
Jayaram H.N., Cooney D.A., Grusch M., Krupitza G. Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis. Curr. Med. Chem. 1999, 6:561-574.
-
(1999)
Curr. Med. Chem.
, vol.6
, pp. 561-574
-
-
Jayaram, H.N.1
Cooney, D.A.2
Grusch, M.3
Krupitza, G.4
-
14
-
-
0025232817
-
Two distinct cDNAs for human IMP dehydrogenase
-
Natsumeda Y., Ohno S., Kawasaki H., Konno Y., Weber G., Suzuki K. Two distinct cDNAs for human IMP dehydrogenase. J. Biol. Chem. 1990, 265:5292-5295.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 5292-5295
-
-
Natsumeda, Y.1
Ohno, S.2
Kawasaki, H.3
Konno, Y.4
Weber, G.5
Suzuki, K.6
-
15
-
-
0028343293
-
Tissue-differential expression of two distinct genes for human IMP dehydrogenase
-
Senda M., Natsumeda Y. Tissue-differential expression of two distinct genes for human IMP dehydrogenase. Life Sci. 1994, 54:1917-1926.
-
(1994)
Life Sci.
, vol.54
, pp. 1917-1926
-
-
Senda, M.1
Natsumeda, Y.2
-
16
-
-
0026707780
-
Increased inosine-5'-phosphate dehydrogenase gene expression in solid tumor tissues and tumor cell lines
-
Collart F.R., Chubb C.B., Mirkin B.L., Huberman E. Increased inosine-5'-phosphate dehydrogenase gene expression in solid tumor tissues and tumor cell lines. Cancer Res. 1992, 52:5826-5828.
-
(1992)
Cancer Res.
, vol.52
, pp. 5826-5828
-
-
Collart, F.R.1
Chubb, C.B.2
Mirkin, B.L.3
Huberman, E.4
-
17
-
-
0033616611
-
Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design
-
Colby T.D., Vanderveen K., Strickler M.D., Markham G.D., Goldstein B.M. Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design. Proc. Natl. Acad. Sci. USA 1999, 96:3531-3536.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 3531-3536
-
-
Colby, T.D.1
Vanderveen, K.2
Strickler, M.D.3
Markham, G.D.4
Goldstein, B.M.5
-
18
-
-
0026378294
-
Selective up-regulation of type II inosine 5'-monophosphate dehydrogenase messenger RNA expression in human leukemias
-
Nagai M., Natsumeda Y., Konno Y., Hoffman R., Irino S., Weber G. Selective up-regulation of type II inosine 5'-monophosphate dehydrogenase messenger RNA expression in human leukemias. Cancer Res. 1991, 51:3886-3890.
-
(1991)
Cancer Res.
, vol.51
, pp. 3886-3890
-
-
Nagai, M.1
Natsumeda, Y.2
Konno, Y.3
Hoffman, R.4
Irino, S.5
Weber, G.6
-
19
-
-
0020640494
-
Enzymes of purine metabolism in cancer
-
Weber G. Enzymes of purine metabolism in cancer. Clin. Biochem. 1983, 16:57-63.
-
(1983)
Clin. Biochem.
, vol.16
, pp. 57-63
-
-
Weber, G.1
-
20
-
-
0032523010
-
Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes
-
Laliberté J., Yee A., Xiong Y., Mitchell B.S. Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes. Blood 1998, 91:2896-2904.
-
(1998)
Blood
, vol.91
, pp. 2896-2904
-
-
Laliberté, J.1
Yee, A.2
Xiong, Y.3
Mitchell, B.S.4
-
21
-
-
33646439982
-
Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target
-
Chong C.R., Qian D.Z., Pan F., Wei Y., Pili R., Sullivan D.J., Liu J.O. Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target. J. Med. Chem. 2006, 49:2677-2680.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 2677-2680
-
-
Chong, C.R.1
Qian, D.Z.2
Pan, F.3
Wei, Y.4
Pili, R.5
Sullivan, D.J.6
Liu, J.O.7
-
22
-
-
39549088916
-
Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery
-
Shu Q., Nair V. Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery. Med. Res. Rev. 2008, 28:219-232.
-
(2008)
Med. Res. Rev.
, vol.28
, pp. 219-232
-
-
Shu, Q.1
Nair, V.2
-
23
-
-
0031910134
-
Inosine-5'-monophosphate dehydrogenase is a rate-determining factor for p53-dependent growth regulation
-
Liu Y., Bohn S.A., Sherley J.L. Inosine-5'-monophosphate dehydrogenase is a rate-determining factor for p53-dependent growth regulation. Mol. Biol. Cell 1998, 9:15-28.
-
(1998)
Mol. Biol. Cell
, vol.9
, pp. 15-28
-
-
Liu, Y.1
Bohn, S.A.2
Sherley, J.L.3
-
24
-
-
17144373352
-
Immortal DNA strand cosegregation requires p53/IMPDH-dependent asymmetric self-renewal associated with adult stem cells
-
Rambhatla L., Ram-Mohan S., Cheng J.J., Sherley J.L. Immortal DNA strand cosegregation requires p53/IMPDH-dependent asymmetric self-renewal associated with adult stem cells. Cancer Res. 2005, 65:3155-3161.
-
(2005)
Cancer Res.
, vol.65
, pp. 3155-3161
-
-
Rambhatla, L.1
Ram-Mohan, S.2
Cheng, J.J.3
Sherley, J.L.4
-
25
-
-
79960360757
-
Von Hippel-Lindau protein promotes Skp2 destabilization on DNA damage
-
Roe J.S., Kim H.R., Hwang I.Y., Cho E.J., Youn H.D. Von Hippel-Lindau protein promotes Skp2 destabilization on DNA damage. Oncogene 2011, 30:3127-3138.
-
(2011)
Oncogene
, vol.30
, pp. 3127-3138
-
-
Roe, J.S.1
Kim, H.R.2
Hwang, I.Y.3
Cho, E.J.4
Youn, H.D.5
-
26
-
-
53949088050
-
Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA
-
Heo I., Joo C., Cho J., Ha M., Han J., Kim V.N. Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol. Cell 2008, 32:276-284.
-
(2008)
Mol. Cell
, vol.32
, pp. 276-284
-
-
Heo, I.1
Joo, C.2
Cho, J.3
Ha, M.4
Han, J.5
Kim, V.N.6
-
27
-
-
34247592358
-
Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase
-
Mizushina Y., Dairaku I., Yanaka N., Takeuchi T., Ishimaru C., Sugawara F., Yoshida H., Kato N. Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase. Biochimie 2007, 89:581-590.
-
(2007)
Biochimie
, vol.89
, pp. 581-590
-
-
Mizushina, Y.1
Dairaku, I.2
Yanaka, N.3
Takeuchi, T.4
Ishimaru, C.5
Sugawara, F.6
Yoshida, H.7
Kato, N.8
-
28
-
-
0034985396
-
Nonradioactive determination of Ras-GTP levels using activated Ras interaction assay
-
Taylor S.J., Resnick R.J., Shalloway D. Nonradioactive determination of Ras-GTP levels using activated Ras interaction assay. Methods Enzymol. 2001, 333:333-342.
-
(2001)
Methods Enzymol.
, vol.333
, pp. 333-342
-
-
Taylor, S.J.1
Resnick, R.J.2
Shalloway, D.3
-
29
-
-
33646140913
-
P53 stabilization and transactivation by a von Hippel-Lindau protein
-
Roe J.S., Kim H., Lee S.M., Kim S.T., Cho E.J., Youn H.D. P53 stabilization and transactivation by a von Hippel-Lindau protein. Mol. Cell 2006, 22:395-405.
-
(2006)
Mol. Cell
, vol.22
, pp. 395-405
-
-
Roe, J.S.1
Kim, H.2
Lee, S.M.3
Kim, S.T.4
Cho, E.J.5
Youn, H.D.6
-
30
-
-
67349272249
-
A nucleocytoplasmic malate dehydrogenase regulates p53 transcriptional activity in response to metabolic stress
-
Lee S.M., Kim J.H., Cho E.J., Youn H.D. A nucleocytoplasmic malate dehydrogenase regulates p53 transcriptional activity in response to metabolic stress. Cell Death Differ. 2009, 16:738-748.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 738-748
-
-
Lee, S.M.1
Kim, J.H.2
Cho, E.J.3
Youn, H.D.4
-
31
-
-
18344365862
-
Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities
-
He G., Siddik Z.H., Huang Z., Wang R., Koomen J., Kobayashi R., Khokhar A.R., Kuang J. Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities. Oncogene 2005, 24:2929-2943.
-
(2005)
Oncogene
, vol.24
, pp. 2929-2943
-
-
He, G.1
Siddik, Z.H.2
Huang, Z.3
Wang, R.4
Koomen, J.5
Kobayashi, R.6
Khokhar, A.R.7
Kuang, J.8
-
32
-
-
42449114966
-
Transcriptional control of human p53-regulated genes
-
Riley T., Sontag E., Chen P., Levine A. Transcriptional control of human p53-regulated genes. Nat. Rev. Mol. Cell Biol. 2008, 9:402-412.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 402-412
-
-
Riley, T.1
Sontag, E.2
Chen, P.3
Levine, A.4
-
33
-
-
77955323879
-
A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response
-
Huarte M., Guttman M., Feldser D., Garber M., Koziol M.J., Kenzelmann-Broz D., Khalil A.M., Zuk O., Amit I., Rabani M., Attardi L.D., Regev A., Lander E.S., Jacks T., Rinn J.L. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 2010, 142:409-419.
-
(2010)
Cell
, vol.142
, pp. 409-419
-
-
Huarte, M.1
Guttman, M.2
Feldser, D.3
Garber, M.4
Koziol, M.J.5
Kenzelmann-Broz, D.6
Khalil, A.M.7
Zuk, O.8
Amit, I.9
Rabani, M.10
Attardi, L.D.11
Regev, A.12
Lander, E.S.13
Jacks, T.14
Rinn, J.L.15
-
34
-
-
54549108798
-
MicroRNAs to Nanog Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation
-
Tay Y., Zhang J., Thomson A.M., Lim B., Rigoutsos I. MicroRNAs to Nanog Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature 2008, 455:1124-1128.
-
(2008)
Nature
, vol.455
, pp. 1124-1128
-
-
Tay, Y.1
Zhang, J.2
Thomson, A.M.3
Lim, B.4
Rigoutsos, I.5
-
35
-
-
77953563697
-
The code within the code: microRNAs target coding regions
-
Forman J.J., Coller H.A. The code within the code: microRNAs target coding regions. Cell Cycle 2010, 9:1533-1541.
-
(2010)
Cell Cycle
, vol.9
, pp. 1533-1541
-
-
Forman, J.J.1
Coller, H.A.2
-
36
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis R.J. Signal transduction by the JNK group of MAP kinases. Cell 2000, 103:239-252.
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
37
-
-
0028329953
-
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
-
Dérijard B., Hibi M., Wu I.H., Barrett T., Su B., Deng T., Karin M., Davis R.J. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 1994, 76:1025-1037.
-
(1994)
Cell
, vol.76
, pp. 1025-1037
-
-
Dérijard, B.1
Hibi, M.2
Wu, I.H.3
Barrett, T.4
Su, B.5
Deng, T.6
Karin, M.7
Davis, R.J.8
-
38
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
39
-
-
0023655408
-
Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues
-
Hue L., Rider M.H. Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues. Biochem. J. 1987, 245:313-324.
-
(1987)
Biochem. J.
, vol.245
, pp. 313-324
-
-
Hue, L.1
Rider, M.H.2
-
40
-
-
0021981229
-
GTP: a central regulator of cellular anabolism
-
Pall M.L. GTP: a central regulator of cellular anabolism. Curr. Top. Cell. Regul. 1985, 25:1-20.
-
(1985)
Curr. Top. Cell. Regul.
, vol.25
, pp. 1-20
-
-
Pall, M.L.1
-
41
-
-
33750833479
-
GTP induces S-phase cell-cycle arrest and inhibits DNA synthesis in K562 cells but not in normal human peripheral lymphocytes
-
Moosavi M.A., Yazdanparast R., Lotfi A. GTP induces S-phase cell-cycle arrest and inhibits DNA synthesis in K562 cells but not in normal human peripheral lymphocytes. J. Biochem. Mol. Biol. 2006, 39:492-501.
-
(2006)
J. Biochem. Mol. Biol.
, vol.39
, pp. 492-501
-
-
Moosavi, M.A.1
Yazdanparast, R.2
Lotfi, A.3
-
42
-
-
0028578072
-
Signal transduction through the GTP-binding proteins Rac and Rho
-
Ridley A.J. Signal transduction through the GTP-binding proteins Rac and Rho. J. Cell Sci. Suppl. 1994, 18:127-131.
-
(1994)
J. Cell Sci. Suppl.
, vol.18
, pp. 127-131
-
-
Ridley, A.J.1
-
43
-
-
0019450783
-
Role of GTP hydrolysis in microtubule treadmilling and assembly
-
Margolis R.L. Role of GTP hydrolysis in microtubule treadmilling and assembly. Proc. Natl. Acad. Sci. USA 1981, 78:1586-1590.
-
(1981)
Proc. Natl. Acad. Sci. USA
, vol.78
, pp. 1586-1590
-
-
Margolis, R.L.1
-
44
-
-
2342627943
-
Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo
-
McLean J.E., Hamaguchi N., Belenky P., Mortimer S.E., Stanton M., Hedstrom L. Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo. Biochem. J. 2004, 379:243-251.
-
(2004)
Biochem. J.
, vol.379
, pp. 243-251
-
-
McLean, J.E.1
Hamaguchi, N.2
Belenky, P.3
Mortimer, S.E.4
Stanton, M.5
Hedstrom, L.6
-
45
-
-
61349192627
-
IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNA
-
Mortimer S.E., Xu D., McGrew D., Hamaguchi N., Lim H.C., Bowne S.J., Daiger S.P., Hedstrom L. IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNA. J. Biol. Chem. 2008, 283:36354-36360.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 36354-36360
-
-
Mortimer, S.E.1
Xu, D.2
McGrew, D.3
Hamaguchi, N.4
Lim, H.C.5
Bowne, S.J.6
Daiger, S.P.7
Hedstrom, L.8
-
46
-
-
76749134299
-
IMP dehydrogenase is recruited to the transcription complex through serine 2 phosphorylation of RNA polymerase II
-
Park J.H., Ahn S.H. IMP dehydrogenase is recruited to the transcription complex through serine 2 phosphorylation of RNA polymerase II. Biochem. Biophys. Res. Commun. 2010, 392:588-592.
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.392
, pp. 588-592
-
-
Park, J.H.1
Ahn, S.H.2
|