Inactivation of AR and Notch-1 signaling by miR-34a attenuates prostate cancer aggressiveness

American Journal of Translational Research

Volumn 4, Issue 4, 2012, Pages 432-442

  Kashat, Maria ^a   Azzouz, Lyna ^a   Sarkar, Shaan H ^a   Kong, Dejuan ^a   Li, Yiwei ^a   Sarkar, Fazlul H ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AR; MiR 34a; Notch 1; Prostate cancer; Self renewal

Indexed keywords

ANDROGEN RECEPTOR; MICRORNA 34A; NOTCH1 RECEPTOR; PROSTATE SPECIFIC ANTIGEN;

ARTICLE; ATTENUATION; CANCER CELL; CANCER GROWTH; CASTRATION RESISTANT PROSTATE CANCER; CELL FUNCTION; CELL RENEWAL; CONTROLLED STUDY; DISEASE SEVERITY; HUMAN; HUMAN CELL; MALE; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

EID: 84868011894     PISSN: None     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Siegel R, Naishadham D, and Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012; 62: 10-29.
2. Ryan CJ and Tindall DJ. Androgen receptor rediscovered: the new biology and targeting the androgen receptor therapeutically. J Clin Oncol 2011; 29: 3651-3658.
3. Kong D, Heath E, Chen W, Cher M, Powell I, Heilbrun L, Li Y, Ali S, Sethi S, Hassan O, Hwang C, Gupta N, Chitale D, Sakr WA, Menon M, and Sarkar FH. Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment. Am J Transl Res 2012; 4: 14-23.
4. Hu YY, Zheng MH, Zhang R, Liang YM, and Han H. Notch signaling pathway and cancer metastasis. Adv Exp Med Biol 2012; 727: 186-198.
5. Ye QF, Zhang YC, Peng XQ, Long Z, Ming YZ, and He LY. Silencing Notch-1 induces apoptosis and increases the chemosensitivity of prostate cancer cells to docetaxel through Bcl-2 and Bax. Oncol Lett 2012; 3: 879-884.
6. Chen F and Hu SJ. Effect of microRNA-34a in cell cycle, differentiation, and apoptosis: a review. J Biochem Mol Toxicol 2012 26: 79-86.
7. Hermeking H. The miR-34 family in cancer and apoptosis. Cell Death Differ 2010; 17: 193-199.
8. Peurala H, Greco D, Heikkinen T, Kaur S, Bartkova J, Jamshidi M, Aittomaki K, Heikkila P, Bartek J, Blomqvist C, Butzow R, and Nevanlinna H. MiR-34a expression has an effect for lower risk of metastasis and associates with expression patterns predicting clinical outcome in breast cancer. PLoS One 2011; 6: e26122.
9. Liu C, Kelnar K, Liu B, Chen X, Calhoun-Davis T, Li H, Patrawala L, Yan H, Jeter C, Honorio S, Wiggins JF, Bader AG, Fagin R, Brown D, and Tang DG. The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med 2011; 17: 211-215.
10. Kong D, Li Y, Wang Z, Banerjee S, and Sarkar FH. Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer. Cancer Res 2007; 67: 3310-3319.
11. Li Y, Ahmed F, Ali S, Philip PA, Kucuk O, and Sarkar FH. Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells. Cancer Res 2005; 65: 6934-6942.
12. Liu C, Kelnar K, Vlassov AV, Brown D, Wang J, and Tang DG. Distinct microRNA Expression Profiles in Prostate Cancer Stem/Progenitor Cells and Tumor-Suppressive Functions of let-7. Cancer Res 2012; 72: 3393-3404.
13. Attard G, Richards J, and de Bono JS. New strategies in metastatic prostate cancer: targeting the androgen receptor signaling pathway. Clin Cancer Res 2011; 17: 1649-1657.
14. Villaronga MA, Bevan CL, and Belandia B. Notch signaling: a potential therapeutic target in prostate cancer. Curr Cancer Drug Targets 2008; 8: 566-580.
15. Alison MR, Lin WR, Lim SM, and Nicholson U. Cancer stem cells: in the line of fire. Cancer Treat Rev 2012; 38: 589-598.
16. Bin HB, Adhami VM, Asim M, Siddiqui IA, Bhat KM, Zhong W, Saleem M, Din M, Setaluri V, and Mukhtar H. Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator. Clin Cancer Res 2009; 15: 452-459.
17. Leong KG and Gao WQ. The Notch pathway in prostate development and cancer. Differentiation 2008; 76: 699-716.
18. Fenner A. Prostate cancer: Unravelling AR splice variant signalling in CPRC. Nat Rev Urol 2012.
19. Cai H, Memarzadeh S, Stoyanova T, Beharry Z, Kraft AS, and Witte O. Collaboration of Kras and Androgen receptor signaling stimulates EZH2 expression and tumor propagating cells in prostate cancer. Cancer Res 2012.
20. Wen Y, Bi P, Liu W, Asakura A, Keller C, and Kuang S. Constitutive Notch activation upregulates Pax7 and promotes the self-renewal of skeletal muscle satellite cells. Mol Cell Biol 2012; 32: 2300-2311.
21. Wang CY, Wei Q, Han I, Sato S, Ghanbari-Azarnier R, Whetstone H, Poon R, Hu J, Zheng F, Zhang P, Wang W, Wunder JS, and Alman BA. Hedgehog and Notch signaling regulate self-renewal of undifferentiated pleomorphic sarcomas. Cancer Res 2012; 72: 1013-1022.