-
1
-
-
0032584567
-
Regulation of a transcription factor network required for differentiation and metabolism
-
Duncan S.A., Navas M.A., Dufort D., Rossant J., Stoffel M. Regulation of a transcription factor network required for differentiation and metabolism. Science 1998, 281:692-695.
-
(1998)
Science
, vol.281
, pp. 692-695
-
-
Duncan, S.A.1
Navas, M.A.2
Dufort, D.3
Rossant, J.4
Stoffel, M.5
-
2
-
-
0026555197
-
A transcriptional hierarchy involved in mammalian cell-type specification
-
Kuo C.J., Conley P.B., Chen L., Sladek F.M., Darnell J.E., Crabtree G.R. A transcriptional hierarchy involved in mammalian cell-type specification. Nature 1992, 355:457-461.
-
(1992)
Nature
, vol.355
, pp. 457-461
-
-
Kuo, C.J.1
Conley, P.B.2
Chen, L.3
Sladek, F.M.4
Darnell, J.E.5
Crabtree, G.R.6
-
3
-
-
0038241793
-
HNF4: a central regulator of hepatocyte differentiation and function
-
Watt A.J., Garrison W.D., Duncan S.A. HNF4: a central regulator of hepatocyte differentiation and function. Hepatology 2003, 37:1249-1253.
-
(2003)
Hepatology
, vol.37
, pp. 1249-1253
-
-
Watt, A.J.1
Garrison, W.D.2
Duncan, S.A.3
-
4
-
-
0345017786
-
Transcription factors in liver development, differentiation, and regeneration
-
Costa R.H., Kalinichenko V.V., Holterman A.X., Wang X. Transcription factors in liver development, differentiation, and regeneration. Hepatology 2003, 38:1331-1347.
-
(2003)
Hepatology
, vol.38
, pp. 1331-1347
-
-
Costa, R.H.1
Kalinichenko, V.V.2
Holterman, A.X.3
Wang, X.4
-
5
-
-
0035141324
-
Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis
-
Hayhurst G.P., Lee Y.H., Lambert G., Ward J.M., Gonzalez F.J. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol. Cell. Biol. 2001, 21:1393-1403.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1393-1403
-
-
Hayhurst, G.P.1
Lee, Y.H.2
Lambert, G.3
Ward, J.M.4
Gonzalez, F.J.5
-
6
-
-
79951952676
-
Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4alpha
-
Wang Z., Bishop E.P., Burke P.A. Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4alpha. BMC Genomics 2011, 12:128.
-
(2011)
BMC Genomics
, vol.12
, pp. 128
-
-
Wang, Z.1
Bishop, E.P.2
Burke, P.A.3
-
7
-
-
10744227070
-
Control of pancreas and liver gene expression by HNF transcription factors
-
Odom D.T., Zizlsperger N., Gordon D.B., Bell G.W., Rinaldi N.J., Murray H.L., Volkert T.L., Schreiber J., Rolfe P.A., Gifford D.K., Fraenkel E., Bell G.I., Young R.A. Control of pancreas and liver gene expression by HNF transcription factors. Science 2004, 303:1378-1381.
-
(2004)
Science
, vol.303
, pp. 1378-1381
-
-
Odom, D.T.1
Zizlsperger, N.2
Gordon, D.B.3
Bell, G.W.4
Rinaldi, N.J.5
Murray, H.L.6
Volkert, T.L.7
Schreiber, J.8
Rolfe, P.A.9
Gifford, D.K.10
Fraenkel, E.11
Bell, G.I.12
Young, R.A.13
-
8
-
-
0034892164
-
Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences
-
Ryffel G.U. Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences. J. Mol. Endocrinol. 2001, 27:11-29.
-
(2001)
J. Mol. Endocrinol.
, vol.27
, pp. 11-29
-
-
Ryffel, G.U.1
-
9
-
-
10544236911
-
Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
-
Yamagata K., Furuta H., Oda N., Kaisaki P.J., Menzel S., Cox N.J., Fajans S.S., Signorini S., Stoffel M., Bell G.I. Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1). Nature 1996, 384:458-460.
-
(1996)
Nature
, vol.384
, pp. 458-460
-
-
Yamagata, K.1
Furuta, H.2
Oda, N.3
Kaisaki, P.J.4
Menzel, S.5
Cox, N.J.6
Fajans, S.S.7
Signorini, S.8
Stoffel, M.9
Bell, G.I.10
-
10
-
-
0037113238
-
Hepatocyte nuclear factor 4 response to injury involves a rapid decrease in DNA binding and transactivation via a JAK2 signal transduction pathway
-
Li X., Salisbury-Rowswell J., Murdock A.D., Forse R.A., Burke P.A. Hepatocyte nuclear factor 4 response to injury involves a rapid decrease in DNA binding and transactivation via a JAK2 signal transduction pathway. Biochem. J. 2002, 368:203-211.
-
(2002)
Biochem. J.
, vol.368
, pp. 203-211
-
-
Li, X.1
Salisbury-Rowswell, J.2
Murdock, A.D.3
Forse, R.A.4
Burke, P.A.5
-
11
-
-
34447325924
-
Effects of hepatocyte nuclear factor-4alpha on the regulation of the hepatic acute phase response
-
Wang Z., Burke P.A. Effects of hepatocyte nuclear factor-4alpha on the regulation of the hepatic acute phase response. J. Mol. Biol. 2007, 371:323-335.
-
(2007)
J. Mol. Biol.
, vol.371
, pp. 323-335
-
-
Wang, Z.1
Burke, P.A.2
-
12
-
-
0036923739
-
Dynamics of enhancer-promoter communication during differentiation-induced gene activation
-
Hatzis P., Talianidis I. Dynamics of enhancer-promoter communication during differentiation-induced gene activation. Mol. Cell 2002, 10:1467-1477.
-
(2002)
Mol. Cell
, vol.10
, pp. 1467-1477
-
-
Hatzis, P.1
Talianidis, I.2
-
13
-
-
0034796563
-
Regulatory mechanisms controlling human hepatocyte nuclear factor 4alpha gene expression
-
Hatzis P., Talianidis I. Regulatory mechanisms controlling human hepatocyte nuclear factor 4alpha gene expression. Mol. Cell. Biol. 2001, 21:7320-7330.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 7320-7330
-
-
Hatzis, P.1
Talianidis, I.2
-
14
-
-
0035445820
-
An enhancer element 6kb upstream of the mouse HNF4alpha1 promoter is activated by glucocorticoids and liver-enriched transcription factors
-
Bailly A., Torres-Padilla M.E., Tinel A.P., Weiss M.C. An enhancer element 6kb upstream of the mouse HNF4alpha1 promoter is activated by glucocorticoids and liver-enriched transcription factors. Nucleic Acids Res. 2001, 29:3495-3505.
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 3495-3505
-
-
Bailly, A.1
Torres-Padilla, M.E.2
Tinel, A.P.3
Weiss, M.C.4
-
15
-
-
0031127252
-
Serine/threonine phosphorylation of orphan receptor hepatocyte nuclear factor 4
-
Jiang G., Nepomuceno L., Yang Q., Sladek F.M. Serine/threonine phosphorylation of orphan receptor hepatocyte nuclear factor 4. Arch. Biochem. Biophys. 1997, 340:1-9.
-
(1997)
Arch. Biochem. Biophys.
, vol.340
, pp. 1-9
-
-
Jiang, G.1
Nepomuceno, L.2
Yang, Q.3
Sladek, F.M.4
-
16
-
-
0030877342
-
Protein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4
-
Viollet B., Kahn A., Raymondjean M. Protein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4. Mol. Cell. Biol. 1997, 17:4208-4219.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 4208-4219
-
-
Viollet, B.1
Kahn, A.2
Raymondjean, M.3
-
17
-
-
79958824196
-
Quantitative analysis of cytokine-induced hepatocyte nuclear factor-4alpha phosphorylation by mass spectrometry
-
Wang Z., Salih E., Burke P.A. Quantitative analysis of cytokine-induced hepatocyte nuclear factor-4alpha phosphorylation by mass spectrometry. Biochemistry 2011, 50:5292-5300.
-
(2011)
Biochemistry
, vol.50
, pp. 5292-5300
-
-
Wang, Z.1
Salih, E.2
Burke, P.A.3
-
18
-
-
0033636892
-
Acetylation regulates transcription factor activity at multiple levels
-
Soutoglou E., Katrakili N., Talianidis I. Acetylation regulates transcription factor activity at multiple levels. Mol. Cell 2000, 5:745-751.
-
(2000)
Mol. Cell
, vol.5
, pp. 745-751
-
-
Soutoglou, E.1
Katrakili, N.2
Talianidis, I.3
-
19
-
-
0033605598
-
CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression
-
Dell H., Hadzopoulou-Cladaras M. CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression. J. Biol. Chem. 1999, 274:9013-9021.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 9013-9021
-
-
Dell, H.1
Hadzopoulou-Cladaras, M.2
-
20
-
-
54049099951
-
Modulation of hepatocyte nuclear factor-4alpha function by the peroxisome-proliferator-activated receptor-gamma co-activator-1alpha in the acute-phase response
-
Wang Z., Burke P.A. Modulation of hepatocyte nuclear factor-4alpha function by the peroxisome-proliferator-activated receptor-gamma co-activator-1alpha in the acute-phase response. Biochem. J. 2008, 415:289-296.
-
(2008)
Biochem. J.
, vol.415
, pp. 289-296
-
-
Wang, Z.1
Burke, P.A.2
-
21
-
-
0032553439
-
SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4
-
Wang J.C., Stafford J.M., Granner D.K. SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4. J. Biol. Chem. 1998, 273:30847-30850.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 30847-30850
-
-
Wang, J.C.1
Stafford, J.M.2
Granner, D.K.3
-
23
-
-
0347444723
-
MicroRNAs: genomics, biogenesis, mechanism, and function
-
Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
-
(2004)
Cell
, vol.116
, pp. 281-297
-
-
Bartel, D.P.1
-
24
-
-
61849137222
-
Many roads to maturity: microRNA biogenesis pathways and their regulation
-
Winter J., Jung S., Keller S., Gregory R.I., Diederichs S. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat. Cell Biol. 2009, 11:228-234.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 228-234
-
-
Winter, J.1
Jung, S.2
Keller, S.3
Gregory, R.I.4
Diederichs, S.5
-
25
-
-
11844278458
-
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
-
Lewis B.P., Burge C.B., Bartel D.P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005, 120:15-20.
-
(2005)
Cell
, vol.120
, pp. 15-20
-
-
Lewis, B.P.1
Burge, C.B.2
Bartel, D.P.3
-
26
-
-
15244358503
-
Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals
-
Xie X., Lu J., Kulbokas E.J., Golub T.R., Mootha V., Lindblad-Toh K., Lander E.S., Kellis M. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature 2005, 434:338-345.
-
(2005)
Nature
, vol.434
, pp. 338-345
-
-
Xie, X.1
Lu, J.2
Kulbokas, E.J.3
Golub, T.R.4
Mootha, V.5
Lindblad-Toh, K.6
Lander, E.S.7
Kellis, M.8
-
28
-
-
82355171192
-
A systematic analysis of the 3'UTR of HNF4A mRNA reveals an interplay of regulatory elements including miRNA target sites
-
Wirsing A., Senkel S., Klein-Hitpass L., Ryffel G.U. A systematic analysis of the 3'UTR of HNF4A mRNA reveals an interplay of regulatory elements including miRNA target sites. PLoS One 2011, 6:e27438.
-
(2011)
PLoS One
, vol.6
-
-
Wirsing, A.1
Senkel, S.2
Klein-Hitpass, L.3
Ryffel, G.U.4
-
29
-
-
77951157723
-
MicroRNAs regulate human hepatocyte nuclear factor 4alpha, modulating the expression of metabolic enzymes and cell cycle
-
Takagi S., Nakajima M., Kida K., Yamaura Y., Fukami T., Yokoi T. MicroRNAs regulate human hepatocyte nuclear factor 4alpha, modulating the expression of metabolic enzymes and cell cycle. J. Biol. Chem. 2010, 285:4415-4422.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 4415-4422
-
-
Takagi, S.1
Nakajima, M.2
Kida, K.3
Yamaura, Y.4
Fukami, T.5
Yokoi, T.6
-
30
-
-
83255162659
-
An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis
-
Hatziapostolou M., Polytarchou C., Aggelidou E., Drakaki A., Poultsides G.A., Jaeger S.A., Ogata H., Karin M., Struhl K., Hadzopoulou-Cladaras M., Iliopoulos D. An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell 2011, 147:1233-1247.
-
(2011)
Cell
, vol.147
, pp. 1233-1247
-
-
Hatziapostolou, M.1
Polytarchou, C.2
Aggelidou, E.3
Drakaki, A.4
Poultsides, G.A.5
Jaeger, S.A.6
Ogata, H.7
Karin, M.8
Struhl, K.9
Hadzopoulou-Cladaras, M.10
Iliopoulos, D.11
-
31
-
-
84863391693
-
In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4alpha expression
-
Ramamoorthy A., Li L., Gaedigk A., Bradford L.D., Benson E.A., Flockhart D.A., Skaar T.C. In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4alpha expression. Drug Metab. Dispos. 2012, 40:726-733.
-
(2012)
Drug Metab. Dispos.
, vol.40
, pp. 726-733
-
-
Ramamoorthy, A.1
Li, L.2
Gaedigk, A.3
Bradford, L.D.4
Benson, E.A.5
Flockhart, D.A.6
Skaar, T.C.7
-
32
-
-
77956637947
-
Hepatocyte nuclear factor-4alpha interacts with other hepatocyte nuclear factors in regulating transthyretin gene expression
-
Wang Z., Burke P.A. Hepatocyte nuclear factor-4alpha interacts with other hepatocyte nuclear factors in regulating transthyretin gene expression. FEBS J. 2010, 277:4066-4075.
-
(2010)
FEBS J.
, vol.277
, pp. 4066-4075
-
-
Wang, Z.1
Burke, P.A.2
-
33
-
-
20944450160
-
Combinatorial microRNA target predictions
-
Krek A., Grun D., Poy M.N., Wolf R., Rosenberg L., Epstein E.J., MacMenamin P., da Piedade I., Gunsalus K.C., Stoffel M., Rajewsky N. Combinatorial microRNA target predictions. Nat. Genet. 2005, 37:495-500.
-
(2005)
Nat. Genet.
, vol.37
, pp. 495-500
-
-
Krek, A.1
Grun, D.2
Poy, M.N.3
Wolf, R.4
Rosenberg, L.5
Epstein, E.J.6
MacMenamin, P.7
da Piedade, I.8
Gunsalus, K.C.9
Stoffel, M.10
Rajewsky, N.11
-
35
-
-
0036162274
-
Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity
-
Maeda Y., Seidel S.D., Wei G., Liu X., Sladek F.M. Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity. Mol. Endocrinol. 2002, 16:402-410.
-
(2002)
Mol. Endocrinol.
, vol.16
, pp. 402-410
-
-
Maeda, Y.1
Seidel, S.D.2
Wei, G.3
Liu, X.4
Sladek, F.M.5
-
36
-
-
34250851115
-
A microRNA component of the p53 tumour suppressor network
-
He L., He X., Lim L.P., de Stanchina E., Xuan Z., Liang Y., Xue W., Zender L., Magnus J., Ridzon D., Jackson A.L., Linsley P.S., Chen C., Lowe S.W., Cleary M.A., Hannon G.J. A microRNA component of the p53 tumour suppressor network. Nature 2007, 447:1130-1134.
-
(2007)
Nature
, vol.447
, pp. 1130-1134
-
-
He, L.1
He, X.2
Lim, L.P.3
de Stanchina, E.4
Xuan, Z.5
Liang, Y.6
Xue, W.7
Zender, L.8
Magnus, J.9
Ridzon, D.10
Jackson, A.L.11
Linsley, P.S.12
Chen, C.13
Lowe, S.W.14
Cleary, M.A.15
Hannon, G.J.16
-
37
-
-
34249817549
-
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
-
Chang T.C., Wentzel E.A., Kent O.A., Ramachandran K., Mullendore M., Lee K.H., Feldmann G., Yamakuchi M., Ferlito M., Lowenstein C.J., Arking D.E., Beer M.A., Maitra A., Mendell J.T. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol. Cell 2007, 26:745-752.
-
(2007)
Mol. Cell
, vol.26
, pp. 745-752
-
-
Chang, T.C.1
Wentzel, E.A.2
Kent, O.A.3
Ramachandran, K.4
Mullendore, M.5
Lee, K.H.6
Feldmann, G.7
Yamakuchi, M.8
Ferlito, M.9
Lowenstein, C.J.10
Arking, D.E.11
Beer, M.A.12
Maitra, A.13
Mendell, J.T.14
|