Squalene Synthase As a Target for Chagas Disease Therapeutics

PLoS Pathogens

Volumn 10, Issue 5, 2014, Pages

  Shang, Na ^a,b   Li, Qian ^a,b   Ko, Tzu Ping ^a,b   Chan, Hsiu Chien ^a   Li, Jikun ^c   Zheng, Yingying ^a   Huang, Chun Hsiang ^a   Ren, Feifei ^a   Chen, Chun Chi ^a   Zhu, Zhen ^a   Galizzi, Melina ^d   Li, Zhu Hong ^d   Rodrigues Poveda, Carlos A ^e   Gonzalez Pacanowska, Dolores ^e   Veiga Santos, Phercyles ^f,g   de Carvalho, Tecia Maria Ulisses ^f,g   de Souza, Wanderley ^f,g   Urbina, Julio A ^h   Wang, Andrew H J ^b   Docampo, Roberto ^d   Li, Kai ⁱ   Liu, Yi Liang ⁱ   Oldfield, Eric ^c,i   Guo, Rey Ting ^a   more..

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d UNIVERSITY OF GEORGIA   (United States)

^e INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^f FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^g INSTITUTO NACIONAL DE METROLOGIA   (Brazil)

^h INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

ⁱ UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITRYPANOSOMAL AGENT; BISPHOSPHONIC ACID DERIVATIVE; ENZYME INHIBITOR; FARNESYL DIPHOSPHATE; ISOPRENOID PHOSPHATE; PROTEIN BINDING; QUINUCLIDINE DERIVATIVE; SESQUITERPENE; SQUALENE SYNTHASE;

ANIMAL; ANTAGONISTS AND INHIBITORS; CHAGAS DISEASE; CHEMICAL STRUCTURE; CHEMISTRY; CHLOROCEBUS AETHIOPS; ENZYMOLOGY; HUMAN; METABOLISM; MOLECULARLY TARGETED THERAPY; PROCEDURES; TRYPANOSOMA CRUZI; VERO CELL LINE; X RAY CRYSTALLOGRAPHY;

ANIMALS; CERCOPITHECUS AETHIOPS; CHAGAS DISEASE; CRYSTALLOGRAPHY, X-RAY; DIPHOSPHONATES; ENZYME INHIBITORS; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; HUMANS; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY; POLYISOPRENYL PHOSPHATES; PROTEIN BINDING; QUINUCLIDINES; SESQUITERPENES; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI; VERO CELLS;

EID: 84901682377     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004114     Document Type: Article

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