Mechanism of action and inhibition of dehydrosqualene synthase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 50, 2010, Pages 21337-21342

  Lin, Fu Yang ^a   Liu, Chia I ^b,c,d   Liu, Yi Liang ^a   Zhang, Yonghui ^a   Wang, Ke ^a   Jeng, Wen Yih ^c,d   Ko, Tzu Ping ^c,d   Cao, Rong ^a   Wang, Andrew H J ^b,c,d   Oldfield, Eric ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^d ACADEMIA SINICA   (Taiwan)

Author keywords

Drug discovery; Quinuclidine; Staphyloxanthin; Triterpene; X ray crystallography

Indexed keywords

ALKENE; CATION; DEHYDROSQUALENE SYNTHASE; ISOPRENOID; MAGNESIUM ION; PYROPHOSPHATE; SQUALENE SYNTHASE; TERPENE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE; IONIZATION; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; STAPHYLOCOCCUS AUREUS;

ALKYL AND ARYL TRANSFERASES; ANIMALS; BACTERIAL PROTEINS; CATALYSIS; CATIONS; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; HUMANS; MOLECULAR STRUCTURE; POLYISOPRENYL PHOSPHATES; SQUALENE;

STAPHYLOCOCCUS AUREUS;

EID: 78650722294     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1010907107     Document Type: Article

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