Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in staphylococcus aureus

Journal of Medicinal Chemistry

Volumn 52, Issue 4, 2009, Pages 976-988

  Song, Yongcheng ^a   Lin, Fu Yang ^a   Yin, Fenglin ^a   Hensler, Mary ^b   Poveda, Carlos A Rodrígues ^c   Mukkamala, Dushyant ^a   Cao, Rong ^a   Wang, Hong ^d   Morita, Craig T ^d   Pacanowska, Dolores González ^c   Nizet, Victor ^b   Oldfield, Eric ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^d UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 PHOSPHONO 2 (3 PHENOXYPHENYL)ETHYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 3 (3 PHENOXYPHENYL)PROPYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 (3 BENZYLPHENYL)BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 (3 PHENOXYPHENYL)BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 (3 PHENYLAMINOPHENYL)BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 (4 BIPHENYL)BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 (4 PHENOXYPHENYL)BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 (9 ETHYLCARBAZOLE 3 YL)BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 [3 (2 BENZYLPHENOXY)PHENYL]BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 [3 (2 FLUOROPHENOXY)PHENYL]BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 [3 (2 TRIFLUOROMETHYLPHENOXY)PHENYL]BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 [3 (3 FLUOROPHENOXY)PHENYL]BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 [3 (3 TRIFLUOROMETHYLPHENOXY)PHENYL]BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 [3 (4 BENZYLPHENOXY)PHENYL]BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 [3 (4 CHLOROPHENOXY)PHENYL]BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 [3 (4 FLUOROPHENOXY)PHENYL]BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 [3 (4 PROPYLPHENOXY)PHENYL]BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 [3 (4 TERT BUTYLPHENOXY)PHENYL]BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 [3 (4 TRIFLUOROMETHYLPHENOXY)PHENYL]BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 [4 (2,4 DIFLUOROPHENYL)PHENYL]BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 [4 (3 PROPOXYPHENYL)PHENYL]BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 [4 (4 BUTYLPHENYL)PHENYL]BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 1 PHOSPHONO 4 [4 (4 METHYLPHENYL)PHENYL]BUTYLSULFONIC ACID TRIPOTASSIUM SALT; 4 (4 BIPHENYL)BUTYLDIPHOSPHONIC ACID DIPOTASSIUM SALT; 4 (4 BIPHENYL)BUTYLDIPHOSPHONIC ACID TETRAPOTASSIUM SALT; 4 [4 (4 TRIFLUOROMETHYLPHENYL)PHENYL)]BUTYLDIPHOSPHONIC ACID DIPOTASSIUM SALT; SQUALENE SYNTHASE INHIBITOR; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; XANTHINE DERIVATIVE;

ARTICLE; BACTERIAL VIRULENCE; BIOSYNTHESIS; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; NONHUMAN; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; ENZYME INHIBITORS; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; HUMANS; INHIBITORY CONCENTRATION 50; STAPHYLOCOCCUS AUREUS; SULFONIC ACIDS; XANTHOPHYLLS;

EID: 64349124952     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm801023u     Document Type: Article

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