Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents

European Journal of Medicinal Chemistry

Volumn 60, Issue , 2013, Pages 431-440

  Recher, Marion ^a   Barboza, Alejandro P ^a   Li, Zhu Hong ^b   Galizzi, Melina ^b   Ferrer Casal, Mariana ^a   Szajnman, Sergio H ^a   Docampo, Roberto ^b   Moreno, Silvia N J ^b   Rodriguez, Juan B ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

Antiparasitic agents; Chagas disease; Farnesyl diphosphate synthase; Toxoplasma gondii; Toxoplasmosis; Trypanosoma cruzi

Indexed keywords

1 [(ETHYLTHIO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N BUTYLSULFINYL)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N BUTYLTHIO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N DECYLTHIO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N HEPT 2 YLAMINO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N HEPTYLAMINO)ETHYL] 1 HYDROXY 1,1 BISPHOSPHONIC ACID; 1 [(N HEPTYLSULFINYL)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N HEPTYLTHIO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N HEXYLSULFINYL)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N HEXYLTHIO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N NONYLTHIO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N OCTYLSULFINYL)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N OCTYLTHIO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N PENTYLSULFINYL)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N PENTYLTHIO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N PROPYLTHIO)ETHYL] 1,1 BISPHOSPHONIC ACID; ANTIINFECTIVE AGENT; ANTIPARASITIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; GERANYLTRANSFERASE; TETRAETHYL 1 [(ETHYLTHIO)ETHYL] 1,1 BISPHOSPHONATE; TETRAETHYL 1 [(N BUT 1 YLTHIO)ETHYL] 1,1 BISPHOSPHONATE; TETRAETHYL 1 [(N DEC 1 YLTHIO)ETHYL] 1,1 BISPHOSPHONATE; TETRAETHYL 1 [(N HEPT 1 YLTHIO)ETHYL] 1,1 BISPHOSPHONATE; TETRAETHYL 1 [(N HEX 1 YLTHIO)ETHYL] 1,1 BISPHOSPHONATE; TETRAETHYL 1 [(N NON 1 YLTHIO)ETHYL] 1,1 BISPHOSPHONATE; TETRAETHYL 1 [(N OCT 1 YLTHIO)ETHYL] 1,1 BISPHOSPHONATE; TETRAETHYL 1 [(N PENT 1 YLTHIO)ETHYL] 1,1 BISPHOSPHONATE; TETRAETHYL 1 [(N PROP 1 YLTHIO)ETHYL] 1,1 BISPHOSPHONATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMASTIGOTE; ANTIMICROBIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHAGAS DISEASE; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; OXIDATION; PROTON NUCLEAR MAGNETIC RESONANCE; TACHYZOITE; TOXOPLASMA GONDII; TOXOPLASMOSIS; TRYPANOSOMA CRUZI;

ANTIPROTOZOAL AGENTS; DIPHOSPHONATES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFUR; TOXOPLASMA; TRYPANOSOMA CRUZI;

EID: 84872132292     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.015     Document Type: Article

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