A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence

Science

Volumn 319, Issue 5868, 2008, Pages 1391-1394

  Liu, Chia I ^a,b,c   Liu, George Y ^d   Song, Yongcheng ^e   Yin, Fenglin ^e   Hensler, Mary E ^f   Jeng, Wen Yih ^a,b   Nizet, Victor ^f,g   Wang, Andrew H J ^a,b,c   Oldfield, Eric ^e  

^a INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^b ACADEMIA SINICA   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d CEDARS SINAI MEDICAL CENTER   (United States)

^e UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^f UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^g UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; BPH 651; BPH 652; BPH 660; BPH 661; BPH 673; BPH 674; BPH 698; BPH 700; CAROTENOID; DEHYDROSQUALENE SYNTHASE; FARNESYL THIODIPHOSPHATE; SQUALENE SYNTHASE; SQUALENE SYNTHASE INHIBITOR; STAPHYLOXANTHIN; UNCLASSIFIED DRUG;

BACTERIUM; BIOCHEMISTRY; CAROTENOID; CRYSTAL STRUCTURE; DISEASE TREATMENT; ENZYME ACTIVITY; IMMUNE SYSTEM; INHIBITOR; METABOLISM; RODENT; STEROL; VIRULENCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL VIRULENCE; BACTERICIDAL ACTIVITY; BLOOD; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SCREENING; DRUG STRUCTURE; ENZYME STRUCTURE; IN VITRO STUDY; INHIBITION KINETICS; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CELL LINE; CELL PROLIFERATION; CHOLESTEROL; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; HUMANS; MICE; MOLECULAR SEQUENCE DATA; ORGANOTHIOPHOSPHORUS COMPOUNDS; POLYISOPRENYL PHOSPHATES; PROTEIN STRUCTURE, SECONDARY; SESQUITERPENES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VIRULENCE; XANTHOPHYLLS;

STAPHYLOCOCCUS AUREUS;

EID: 40449088993     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1153018     Document Type: Article

References (19)