1-Hydroxy-3-(methylpentylamino)-propylidene-1,1,-bisphosphonic acid as a potent inhibitor of squalene synthase

Arzneimittel-Forschung/Drug Research

Volumn 46, Issue 8, 1996, Pages 759-762

  Amin, Dilip ^a   Cornell, Susan A ^a,b   Perrone, Mark H ^a   Bilder, Glenda E ^a  

^a SANOFI   (France)

^b Sandoz Pharma Ltd   (Switzerland)

Author keywords

1 hydroxy 3 ( methylpentylamino) propylidene 1, 1 bisphosphonic acid; bisphosphonates; BM 21.0955, pharmacology, squalene synthase inhibition; cholesterol; lipid reducers

Indexed keywords

FARNESYL DIPHOSPHATE; HYPOCHOLESTEROLEMIC AGENT; IBANDRONIC ACID; MEVALONIC ACID; PRESQUALENE PYROPHOSPHATE; RADIOISOTOPE; SQUALENE; SQUALENE SYNTHASE; SQUALENE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL FREE SYSTEM; CELL LINE; CHOLESTEROL SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; LIPOPHILICITY; LIVER MICROSOME; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; RAT; STEROL SYNTHESIS;

ANIMALS; BONE RESORPTION; CELL LINE; CELL-FREE SYSTEM; CHOLESTEROL; DIPHOSPHONATES; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; LANOSTEROL; MEVALONIC ACID; MICE; MICROSOMES, LIVER; OCTANOIC ACIDS; RATS;

EID: 0029791778     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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