메뉴 건너뛰기




Volumn 389, Issue 1-2, 2014, Pages 40-47

Non-feminizing estrogens: A novel neuroprotective therapy

Author keywords

Alzheimer's disease; Estradiol; Estrogen receptors; Neuroprotection; Non feminizing estrogens; Traumatic brain injury

Indexed keywords

17ALPHA ESTRADIOL; ESTRADIOL; ESTROGEN; ESTROGEN DERIVATIVE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTRONE; G 1; GENISTEIN; HORMONE RECEPTOR STIMULATING AGENT; PLACEBO; UNCLASSIFIED DRUG; ESTROGEN RECEPTOR; NEUROPROTECTIVE AGENT;

EID: 84901491465     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2013.12.017     Document Type: Review
Times cited : (20)

References (93)
  • 1
    • 77954558825 scopus 로고    scopus 로고
    • Alzheimer's disease therapeutic research: the path forward
    • Online Only
    • Aisen P.S. Alzheimer's disease therapeutic research: the path forward. Alzheimer's Res. Ther. 2009, 1(1). Online Only.
    • (2009) Alzheimer's Res. Ther. , vol.1 , Issue.1
    • Aisen, P.S.1
  • 4
    • 65249125762 scopus 로고    scopus 로고
    • Sex differences in stroke epidemiology: a systematic review
    • Appelros P., Stegmayr B., Terent A. Sex differences in stroke epidemiology: a systematic review. Stroke 2009, 40:1082-1090.
    • (2009) Stroke , vol.40 , pp. 1082-1090
    • Appelros, P.1    Stegmayr, B.2    Terent, A.3
  • 8
    • 13444311864 scopus 로고    scopus 로고
    • Requirements of a brain selective estrogen: advances and remaining challenges for developing a NeuroSERM
    • Brinton R.D. Requirements of a brain selective estrogen: advances and remaining challenges for developing a NeuroSERM. J. Alzheimer's Dis. 2004, 6:S27-S35.
    • (2004) J. Alzheimer's Dis. , vol.6
    • Brinton, R.D.1
  • 9
    • 18844395104 scopus 로고    scopus 로고
    • 17-Beta estradiol rapidly enhances extracellular signal-regulated kinase 2 phosphorylation in the rat brain
    • Bryant D.N., Bosch M.A., Rønnekleiv O.K., Dorsa D.M. 17-Beta estradiol rapidly enhances extracellular signal-regulated kinase 2 phosphorylation in the rat brain. Neuroscience 2005, 133:343-352.
    • (2005) Neuroscience , vol.133 , pp. 343-352
    • Bryant, D.N.1    Bosch, M.A.2    Rønnekleiv, O.K.3    Dorsa, D.M.4
  • 10
    • 0035743291 scopus 로고    scopus 로고
    • Estrogen modulation of the cyclic AMP response element-binding protein pathway. Effects of long-term and acute treatments
    • Carlstrom L., Ke Z.J., Unnerstall J.R., Cohen R.S., Pandey S.C. Estrogen modulation of the cyclic AMP response element-binding protein pathway. Effects of long-term and acute treatments. Neuroendocrinology 2001, 74:227-243.
    • (2001) Neuroendocrinology , vol.74 , pp. 227-243
    • Carlstrom, L.1    Ke, Z.J.2    Unnerstall, J.R.3    Cohen, R.S.4    Pandey, S.C.5
  • 14
    • 16344390950 scopus 로고    scopus 로고
    • Vascular consequences of menopause and hormone therapy: importance of timing of treatment and type of estrogen
    • Dubey R.K., Imthurn B., Barton M., Jackson E.K. Vascular consequences of menopause and hormone therapy: importance of timing of treatment and type of estrogen. Cardiovasc. Res. 2005, 66:295-306.
    • (2005) Cardiovasc. Res. , vol.66 , pp. 295-306
    • Dubey, R.K.1    Imthurn, B.2    Barton, M.3    Jackson, E.K.4
  • 15
    • 37349024272 scopus 로고    scopus 로고
    • Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: evidence for the critical period hypothesis
    • Dumas J., Hancur-Bucci C., Naylor M., Sites C., Newhouse P. Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: evidence for the critical period hypothesis. Horm. Behav. 2008, 53:159-169.
    • (2008) Horm. Behav. , vol.53 , pp. 159-169
    • Dumas, J.1    Hancur-Bucci, C.2    Naylor, M.3    Sites, C.4    Newhouse, P.5
  • 17
    • 79960557155 scopus 로고    scopus 로고
    • Neuroprotective actions of estradiol and novel estrogen analogs in ischemia: translational implications
    • Etgen A.M., Jover-Mengual T., Zukin R.S. Neuroprotective actions of estradiol and novel estrogen analogs in ischemia: translational implications. Front. Neuroendocrinol. 2011, 32:336-352.
    • (2011) Front. Neuroendocrinol. , vol.32 , pp. 336-352
    • Etgen, A.M.1    Jover-Mengual, T.2    Zukin, R.S.3
  • 18
    • 0036127836 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer
    • Filardo E.J. Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer. J. Steroid Biochem. Mol. Biol. 2002, 80:231-238.
    • (2002) J. Steroid Biochem. Mol. Biol. , vol.80 , pp. 231-238
    • Filardo, E.J.1
  • 19
    • 0033780783 scopus 로고    scopus 로고
    • Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
    • Filardo E.J., Quinn J.A., Bland K.I., Frackelton A.R. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol. Endocrinol. 2000, 14:1649-1660.
    • (2000) Mol. Endocrinol. , vol.14 , pp. 1649-1660
    • Filardo, E.J.1    Quinn, J.A.2    Bland, K.I.3    Frackelton, A.R.4
  • 20
    • 0036320770 scopus 로고    scopus 로고
    • Estrogen-mediated neuroprotection against beta-amyloid toxicity requires expression of estrogen receptor alpha or beta and activation of the MAPK pathway
    • Fitzpatrick J.L., Mize A.L., Wade C.B., Harris J.A., Shapiro R.A., Dorsa D.M. Estrogen-mediated neuroprotection against beta-amyloid toxicity requires expression of estrogen receptor alpha or beta and activation of the MAPK pathway. J. Neurochem. 2002, 82:674-682.
    • (2002) J. Neurochem. , vol.82 , pp. 674-682
    • Fitzpatrick, J.L.1    Mize, A.L.2    Wade, C.B.3    Harris, J.A.4    Shapiro, R.A.5    Dorsa, D.M.6
  • 22
    • 17044439074 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta links neuroprotection by 17beta-estradiol to key Alzheimer processes
    • Goodenough S., Schleusner D., Pietrzik C., Skutella T., Behl C. Glycogen synthase kinase 3beta links neuroprotection by 17beta-estradiol to key Alzheimer processes. Neuroscience 2005, 132:581-589.
    • (2005) Neuroscience , vol.132 , pp. 581-589
    • Goodenough, S.1    Schleusner, D.2    Pietrzik, C.3    Skutella, T.4    Behl, C.5
  • 23
    • 0034513825 scopus 로고    scopus 로고
    • Role of estrogens and estrogen-like non-feminizing compounds in the prevention and treatment of Alzheimer's disease
    • Green P.S., Simpkins J.W. Role of estrogens and estrogen-like non-feminizing compounds in the prevention and treatment of Alzheimer's disease. Ann. N. Y. Acad. Sci. 2000, 924:93-98.
    • (2000) Ann. N. Y. Acad. Sci. , vol.924 , pp. 93-98
    • Green, P.S.1    Simpkins, J.W.2
  • 24
    • 0031021372 scopus 로고    scopus 로고
    • 17 Alpha-estradiol exerts neuroprotective effects on SK-N-SH cells
    • Green P.S., Bishop J., Simpkins J.W. 17 Alpha-estradiol exerts neuroprotective effects on SK-N-SH cells. J. Neurosci. 1997, 17:511-515.
    • (1997) J. Neurosci. , vol.17 , pp. 511-515
    • Green, P.S.1    Bishop, J.2    Simpkins, J.W.3
  • 25
    • 0031404546 scopus 로고    scopus 로고
    • Phenolic A ring requirement for the neuroprotective effects of steroids
    • Green P.S., Gordon K., Simpkins J.W. Phenolic A ring requirement for the neuroprotective effects of steroids. J. Steroid Biochem. Mol. Biol. 1997, 63:229-235.
    • (1997) J. Steroid Biochem. Mol. Biol. , vol.63 , pp. 229-235
    • Green, P.S.1    Gordon, K.2    Simpkins, J.W.3
  • 26
    • 0031940591 scopus 로고    scopus 로고
    • Nuclear estrogen receptor-independent neuroprotection by estratrienes: a novel interaction with glutathione
    • Green P.S., Gridley K.E., Simpkins J.W. Nuclear estrogen receptor-independent neuroprotection by estratrienes: a novel interaction with glutathione. Neuroscience 1998, 84:7-10.
    • (1998) Neuroscience , vol.84 , pp. 7-10
    • Green, P.S.1    Gridley, K.E.2    Simpkins, J.W.3
  • 27
    • 85047686351 scopus 로고    scopus 로고
    • The nonfeminizing enantiomer of 17α-estradiol exerts protective effects in neuronal cultures and a rat model of cerebral ischemia
    • Green P.S., Yang S.H., Nilsson K.R., Kumar A.S., Covey D.F., Simpkins J.W. The nonfeminizing enantiomer of 17α-estradiol exerts protective effects in neuronal cultures and a rat model of cerebral ischemia. Endocrinology 2001, 142:400-406.
    • (2001) Endocrinology , vol.142 , pp. 400-406
    • Green, P.S.1    Yang, S.H.2    Nilsson, K.R.3    Kumar, A.S.4    Covey, D.F.5    Simpkins, J.W.6
  • 28
    • 32044435429 scopus 로고    scopus 로고
    • Hormone therapy and coronary heart disease: the role of time since menopause and age at hormone initiation
    • Grodstein F., Manson J.E., Stampfer M.J. Hormone therapy and coronary heart disease: the role of time since menopause and age at hormone initiation. J. Women's Health 2006, 15:35-44.
    • (2006) J. Women's Health , vol.15 , pp. 35-44
    • Grodstein, F.1    Manson, J.E.2    Stampfer, M.J.3
  • 29
    • 0041878673 scopus 로고    scopus 로고
    • What pharmacologists can learn from recent advances in estrogen signaling
    • Gustafsson J.-Å. What pharmacologists can learn from recent advances in estrogen signaling. Trends Pharmacol. Sci. 2003, 24:479-485.
    • (2003) Trends Pharmacol. Sci. , vol.24 , pp. 479-485
    • Gustafsson, J.-Å.1
  • 30
    • 0035813112 scopus 로고    scopus 로고
    • The multifaceted mechanisms of estradiol and estrogen receptor signaling
    • Hall J.M., Couse J.F., Korach K.S. The multifaceted mechanisms of estradiol and estrogen receptor signaling. J. Biol. Chem. 2001, 276:36869-36872.
    • (2001) J. Biol. Chem. , vol.276 , pp. 36869-36872
    • Hall, J.M.1    Couse, J.F.2    Korach, K.S.3
  • 31
    • 3242731206 scopus 로고    scopus 로고
    • What do hormones have to do with aging? What does aging have to do with hormones?
    • Harman S.M. What do hormones have to do with aging? What does aging have to do with hormones?. Ann. N. Y. Acad. Sci. 2004, 1019:299-308.
    • (2004) Ann. N. Y. Acad. Sci. , vol.1019 , pp. 299-308
    • Harman, S.M.1
  • 35
    • 27744483468 scopus 로고    scopus 로고
    • CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation
    • Hudmon A., Schulman H., Kim J., Maltez J.M., Tsien R.W., Pitt G.S. CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation. J. Cell Biol. 2005, 171:537-547.
    • (2005) J. Cell Biol. , vol.171 , pp. 537-547
    • Hudmon, A.1    Schulman, H.2    Kim, J.3    Maltez, J.M.4    Tsien, R.W.5    Pitt, G.S.6
  • 36
    • 0033853008 scopus 로고    scopus 로고
    • Prevalence of AD among whites: a summary by levels of severity
    • Hy L.X., Keller D.M. Prevalence of AD among whites: a summary by levels of severity. Neurology 2000, 55:198-204.
    • (2000) Neurology , vol.55 , pp. 198-204
    • Hy, L.X.1    Keller, D.M.2
  • 37
    • 0042425738 scopus 로고    scopus 로고
    • Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice
    • Ishizawa T., Sahara N., Ishiguro K., Kersh J., McGowan E., Lewis J., Hutton M., Dickson D.W., Yen S.H. Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice. Am. J. Pathol. 2003, 163:1057-1067.
    • (2003) Am. J. Pathol. , vol.163 , pp. 1057-1067
    • Ishizawa, T.1    Sahara, N.2    Ishiguro, K.3    Kersh, J.4    McGowan, E.5    Lewis, J.6    Hutton, M.7    Dickson, D.W.8    Yen, S.H.9
  • 38
    • 0034727891 scopus 로고    scopus 로고
    • Region- and peptide-specific regulation of the neurotrophins by estrogen
    • Jezierski M.K., Sohrabji F. Region- and peptide-specific regulation of the neurotrophins by estrogen. Brain Res. Mol. Brain Res. 2000, 85:77-84.
    • (2000) Brain Res. Mol. Brain Res. , vol.85 , pp. 77-84
    • Jezierski, M.K.1    Sohrabji, F.2
  • 39
    • 0034623827 scopus 로고    scopus 로고
    • Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C
    • Kamp T.J., Hell J.W. Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C. Circ. Res. 2000, 87:1095-1102.
    • (2000) Circ. Res. , vol.87 , pp. 1095-1102
    • Kamp, T.J.1    Hell, J.W.2
  • 40
    • 0345732757 scopus 로고    scopus 로고
    • 17Beta-estradiol inhibits oxidative stress-induced apoptosis in keratinocytes by promoting Bcl-2 expression
    • Kanda N., Watanabe S. 17Beta-estradiol inhibits oxidative stress-induced apoptosis in keratinocytes by promoting Bcl-2 expression. J. Invest. Dermatol. 2003, 121:1500-1509.
    • (2003) J. Invest. Dermatol. , vol.121 , pp. 1500-1509
    • Kanda, N.1    Watanabe, S.2
  • 41
    • 33746089884 scopus 로고    scopus 로고
    • The Octopus vulgaris estrogen receptor is a constitutive transcriptional activator: evolutionary and functional implications
    • Keay J., Bridgham J.T., Thornton J.W. The Octopus vulgaris estrogen receptor is a constitutive transcriptional activator: evolutionary and functional implications. Endocrinology 2006, 147:3861-3869.
    • (2006) Endocrinology , vol.147 , pp. 3861-3869
    • Keay, J.1    Bridgham, J.T.2    Thornton, J.W.3
  • 43
    • 0036967245 scopus 로고    scopus 로고
    • 17Alpha-estradiol and 17beta-estradiol treatments are effective in lowering cerebral amyloid-beta levels in AbetaPPSWE transgenic mice
    • Levin-Allerhand J.A., Lominska C.E., Wang J., Smith J.D. 17Alpha-estradiol and 17beta-estradiol treatments are effective in lowering cerebral amyloid-beta levels in AbetaPPSWE transgenic mice. J. Alzheimer's Dis. 2002, 4:449-457.
    • (2002) J. Alzheimer's Dis. , vol.4 , pp. 449-457
    • Levin-Allerhand, J.A.1    Lominska, C.E.2    Wang, J.3    Smith, J.D.4
  • 45
    • 74049100935 scopus 로고    scopus 로고
    • Estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin
    • Liang K., Yang L., Yin C., Xiao Z., Zhang J., Liu Y., Huang J. Estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin. J. Biol. Chem. 2010, 285:935-942.
    • (2010) J. Biol. Chem. , vol.285 , pp. 935-942
    • Liang, K.1    Yang, L.2    Yin, C.3    Xiao, Z.4    Zhang, J.5    Liu, Y.6    Huang, J.7
  • 47
    • 48349124965 scopus 로고    scopus 로고
    • Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A
    • Liu X.A., Zhu L.Q., Zhang Q., Shi H.R., Wang S.H., Wang Q., Wang J.Z. Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A. Neurochem. Res. 2008, 33:1811-1820.
    • (2008) Neurochem. Res. , vol.33 , pp. 1811-1820
    • Liu, X.A.1    Zhu, L.Q.2    Zhang, Q.3    Shi, H.R.4    Wang, S.H.5    Wang, Q.6    Wang, J.Z.7
  • 48
    • 33646005802 scopus 로고    scopus 로고
    • Potential importance of early initiation of hormone therapy for cognitive benefit
    • Maki P.M. Potential importance of early initiation of hormone therapy for cognitive benefit. Menopause 2006, 13:6-7.
    • (2006) Menopause , vol.13 , pp. 6-7
    • Maki, P.M.1
  • 49
    • 33646378684 scopus 로고    scopus 로고
    • Steering estrogen signals from the plasma membrane to the nucleus: two sides of the coin
    • Manavathi B., Kumar R. Steering estrogen signals from the plasma membrane to the nucleus: two sides of the coin. J. Cell. Physiol. 2006, 207:594-604.
    • (2006) J. Cell. Physiol. , vol.207 , pp. 594-604
    • Manavathi, B.1    Kumar, R.2
  • 52
    • 0034818022 scopus 로고    scopus 로고
    • Estrogen induces a rapid secretion of amyloid beta precursor protein via the mitogen-activated protein kinase pathway
    • Manthey D., Heck S., Engert S., Behl C. Estrogen induces a rapid secretion of amyloid beta precursor protein via the mitogen-activated protein kinase pathway. Eur. J. Biochem. / FEBS 2001, 268:4285-4291.
    • (2001) Eur. J. Biochem. / FEBS , vol.268 , pp. 4285-4291
    • Manthey, D.1    Heck, S.2    Engert, S.3    Behl, C.4
  • 53
    • 1342288028 scopus 로고    scopus 로고
    • An ICI 182,780-sensitive, membrane-related estrogen receptor contributes to estrogenic neuroprotective actions against amyloid-beta toxicity
    • Marin R., Guerra B., Morales A., Diaz M., Alonso R. An ICI 182,780-sensitive, membrane-related estrogen receptor contributes to estrogenic neuroprotective actions against amyloid-beta toxicity. Ann. N. Y. Acad. Sci. 2003, 1007:108-116.
    • (2003) Ann. N. Y. Acad. Sci. , vol.1007 , pp. 108-116
    • Marin, R.1    Guerra, B.2    Morales, A.3    Diaz, M.4    Alonso, R.5
  • 54
    • 0029980953 scopus 로고    scopus 로고
    • In vitro antioxidant effects of estrogens with a hindered 3-OH function on the copper-induced oxidation of low density lipoprotein
    • Miller C.P., Jirkovsky I., Hayhurst D.A., Adelman S.J. In vitro antioxidant effects of estrogens with a hindered 3-OH function on the copper-induced oxidation of low density lipoprotein. Steroids 1996, 61:305-308.
    • (1996) Steroids , vol.61 , pp. 305-308
    • Miller, C.P.1    Jirkovsky, I.2    Hayhurst, D.A.3    Adelman, S.J.4
  • 56
    • 78149298225 scopus 로고    scopus 로고
    • Analysis of oestrogen regulation of alpha-, beta- and gamma-secretase gene and protein expression in cultured human neuronal and glial cells
    • Nord L.C., Sundqvist J., Andersson E., Fried G. Analysis of oestrogen regulation of alpha-, beta- and gamma-secretase gene and protein expression in cultured human neuronal and glial cells. Neuro-degenerative Dis. 2010, 7:349-364.
    • (2010) Neuro-degenerative Dis. , vol.7 , pp. 349-364
    • Nord, L.C.1    Sundqvist, J.2    Andersson, E.3    Fried, G.4
  • 57
    • 14744293013 scopus 로고    scopus 로고
    • Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo
    • Perez E., Liu R., Yang S.-H., Cai Z.Y., Covey D.F., Simpkins J.W. Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo. Brain Res. 2005, 1038:216-222.
    • (2005) Brain Res. , vol.1038 , pp. 216-222
    • Perez, E.1    Liu, R.2    Yang, S.-H.3    Cai, Z.Y.4    Covey, D.F.5    Simpkins, J.W.6
  • 59
    • 0033625861 scopus 로고    scopus 로고
    • Ovariectomy and 17beta-estradiol modulate the levels of Alzheimer's amyloid beta peptides in brain
    • Petanceska S.S., Nagy V., Frail D., Gandy S. Ovariectomy and 17beta-estradiol modulate the levels of Alzheimer's amyloid beta peptides in brain. Exp. Gerontol. 2000, 35:1317-1325.
    • (2000) Exp. Gerontol. , vol.35 , pp. 1317-1325
    • Petanceska, S.S.1    Nagy, V.2    Frail, D.3    Gandy, S.4
  • 60
    • 65249177143 scopus 로고    scopus 로고
    • Gender differences in stroke incidence and poststroke disability in the framingham heart study
    • Petrea R.E., Beiser A.S., Seshadri S., Kelly-Hayes M., Kase C.S., Wolf P.A. Gender differences in stroke incidence and poststroke disability in the framingham heart study. Stroke 2009, 40:1032-1037.
    • (2009) Stroke , vol.40 , pp. 1032-1037
    • Petrea, R.E.1    Beiser, A.S.2    Seshadri, S.3    Kelly-Hayes, M.4    Kase, C.S.5    Wolf, P.A.6
  • 61
    • 69949132002 scopus 로고    scopus 로고
    • Differential processing of amyloid-β precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells
    • Porayette P., Gallego M.J., Kaltcheva M.M., Bowen R.L., Vadakkadath Meethal S., Atwood C.S. Differential processing of amyloid-β precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells. J. Biol. Chem. 2009, 284:23806-23817.
    • (2009) J. Biol. Chem. , vol.284 , pp. 23806-23817
    • Porayette, P.1    Gallego, M.J.2    Kaltcheva, M.M.3    Bowen, R.L.4    Vadakkadath Meethal, S.5    Atwood, C.S.6
  • 63
    • 67349105361 scopus 로고    scopus 로고
    • Mechanisms of estrogen signaling and gene expression via GPR30
    • Prossnitz E.R., Maggiolini M. Mechanisms of estrogen signaling and gene expression via GPR30. Mol. Cell. Endocrinol. 2009, 308:32-38.
    • (2009) Mol. Cell. Endocrinol. , vol.308 , pp. 32-38
    • Prossnitz, E.R.1    Maggiolini, M.2
  • 66
    • 14844343093 scopus 로고    scopus 로고
    • A transmembrane intracellular estrogen receptor mediates rapid cell signaling
    • Revankar C.M., Cimino D.F., Sklar L.A., Arterburn J.B., Prossnitz E.R. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 2005, 307:1625-1630.
    • (2005) Science , vol.307 , pp. 1625-1630
    • Revankar, C.M.1    Cimino, D.F.2    Sklar, L.A.3    Arterburn, J.B.4    Prossnitz, E.R.5
  • 67
    • 79959404165 scopus 로고    scopus 로고
    • Estrogen protection in Friedreich's ataxia skin fibroblasts
    • Richardson T.E., Yang S.-H., Wen Y., Simpkins J.W. Estrogen protection in Friedreich's ataxia skin fibroblasts. Endocrinology 2011, 152:2742-2749.
    • (2011) Endocrinology , vol.152 , pp. 2742-2749
    • Richardson, T.E.1    Yang, S.-H.2    Wen, Y.3    Simpkins, J.W.4
  • 69
    • 33646271366 scopus 로고    scopus 로고
    • Brief report: coronary heart disease events associated with hormone therapy in younger and older women. A meta-analysis
    • Salpeter S.R., Walsh J.M.E., Greyber E., Salpeter E.E. Brief report: coronary heart disease events associated with hormone therapy in younger and older women. A meta-analysis. J. Gen. Int. Med. 2006, 21:363-366.
    • (2006) J. Gen. Int. Med. , vol.21 , pp. 363-366
    • Salpeter, S.R.1    Walsh, J.M.E.2    Greyber, E.3    Salpeter, E.E.4
  • 71
    • 42449158652 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators: an update on recent clinical findings
    • Shelly W., Draper M.W., Krishnan V., Wong M., Jaffe R.B. Selective estrogen receptor modulators: an update on recent clinical findings. Obstet. Gynecol. Surv. 2008, 63:163-181.
    • (2008) Obstet. Gynecol. Surv. , vol.63 , pp. 163-181
    • Shelly, W.1    Draper, M.W.2    Krishnan, V.3    Wong, M.4    Jaffe, R.B.5
  • 73
    • 84885510257 scopus 로고    scopus 로고
    • Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds
    • Wiley Publishers, A.G. Gravanis, S.H. Mellon (Eds.)
    • Simpkins J.W., Yi K.D., Perez E., Covey D.F. Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds. Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis 2011, 13-28. Wiley Publishers. A.G. Gravanis, S.H. Mellon (Eds.).
    • (2011) Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis , pp. 13-28
    • Simpkins, J.W.1    Yi, K.D.2    Perez, E.3    Covey, D.F.4
  • 76
    • 0032479933 scopus 로고    scopus 로고
    • Modulation of Bcl-2 expression: a potential component of estrogen protection in NT2 neurons
    • Singer C.A., Rogers K.L., Dorsa D.M. Modulation of Bcl-2 expression: a potential component of estrogen protection in NT2 neurons. Neuroreport 1998, 9:2565-2568.
    • (1998) Neuroreport , vol.9 , pp. 2565-2568
    • Singer, C.A.1    Rogers, K.L.2    Dorsa, D.M.3
  • 77
    • 0033118665 scopus 로고    scopus 로고
    • The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons
    • Singer C.A., Figueroa-Masot X.A., Batchelor R.H., Dorsa D.M. The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons. J. Neurosci. 1999, 19:2455-2463.
    • (1999) J. Neurosci. , vol.19 , pp. 2455-2463
    • Singer, C.A.1    Figueroa-Masot, X.A.2    Batchelor, R.H.3    Dorsa, D.M.4
  • 78
    • 0344097487 scopus 로고    scopus 로고
    • Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: convergence of estrogen and neurotrophin signaling pathways
    • Singh M., Sétáló G., Guan X., Warren M., Toran-Allerand C.D. Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: convergence of estrogen and neurotrophin signaling pathways. J. Neurosci. 1999, 19:1179-1188.
    • (1999) J. Neurosci. , vol.19 , pp. 1179-1188
    • Singh, M.1    Sétáló, G.2    Guan, X.3    Warren, M.4    Toran-Allerand, C.D.5
  • 79
    • 0028843912 scopus 로고
    • Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor
    • Sohrabji F., Miranda R.C., Toran-Allerand C.D. Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor. Proc. Natl. Acad. Sci. USA 1995, 92:11110-11114.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 11110-11114
    • Sohrabji, F.1    Miranda, R.C.2    Toran-Allerand, C.D.3
  • 80
    • 1842510667 scopus 로고    scopus 로고
    • Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology
    • Sontag E., Luangpirom A., Hladik C., Mudrak I., Ogris E., Speciale S., White C.L. Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology. J. Neuropathol. Exp. Neurol. 2004, 63:287-301.
    • (2004) J. Neuropathol. Exp. Neurol. , vol.63 , pp. 287-301
    • Sontag, E.1    Luangpirom, A.2    Hladik, C.3    Mudrak, I.4    Ogris, E.5    Speciale, S.6    White, C.L.7
  • 82
    • 0348110368 scopus 로고    scopus 로고
    • Molecular sensors of estrogen receptor conformations and dynamics
    • Tamrazi A., Carlson K.E., Katzenellenbogen J.A. Molecular sensors of estrogen receptor conformations and dynamics. Mol. Endocrinol. 2003, 17:2593-2602.
    • (2003) Mol. Endocrinol. , vol.17 , pp. 2593-2602
    • Tamrazi, A.1    Carlson, K.E.2    Katzenellenbogen, J.A.3
  • 83
    • 36048994244 scopus 로고    scopus 로고
    • A midlife stroke surge among women in the United States
    • Towfighi A., Saver J.L., Engelhardt R., Ovbiagele B. A midlife stroke surge among women in the United States. Neurology 2007, 69:1898-1904.
    • (2007) Neurology , vol.69 , pp. 1898-1904
    • Towfighi, A.1    Saver, J.L.2    Engelhardt, R.3    Ovbiagele, B.4
  • 84
    • 38549085278 scopus 로고    scopus 로고
    • Oestradiol or genistein rescues neurons from amyloid beta-induced cell death by inhibiting activation of p38
    • Valles S.L., Borras C., Gambini J., Furriol J., Ortega A., Sastre J., Pallardo F.V., Vina J. Oestradiol or genistein rescues neurons from amyloid beta-induced cell death by inhibiting activation of p38. Aging Cell 2008, 7:112-118.
    • (2008) Aging Cell , vol.7 , pp. 112-118
    • Valles, S.L.1    Borras, C.2    Gambini, J.3    Furriol, J.4    Ortega, A.5    Sastre, J.6    Pallardo, F.V.7    Vina, J.8
  • 85
    • 79952313774 scopus 로고    scopus 로고
    • Divergent mechanisms for trophic actions of estrogens in the brain and peripheral tissues
    • Walf A.A., Paris J.J., Rhodes M.E., Simpkins J.W., Frye C.A. Divergent mechanisms for trophic actions of estrogens in the brain and peripheral tissues. Brain Res. 2011, 1379:119-136.
    • (2011) Brain Res. , vol.1379 , pp. 119-136
    • Walf, A.A.1    Paris, J.J.2    Rhodes, M.E.3    Simpkins, J.W.4    Frye, C.A.5
  • 86
    • 2542428253 scopus 로고    scopus 로고
    • Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like Tauopathy in female rats
    • Wen Y., Yang S., Liu R., Brun-Zinkernagel A.M., Koulen P., Simpkins J.W. Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like Tauopathy in female rats. J. Biol. Chem. 2004, 279:22684-22692.
    • (2004) J. Biol. Chem. , vol.279 , pp. 22684-22692
    • Wen, Y.1    Yang, S.2    Liu, R.3    Brun-Zinkernagel, A.M.4    Koulen, P.5    Simpkins, J.W.6
  • 91
    • 51649110188 scopus 로고    scopus 로고
    • Role of Dickkopf-1, an antagonist of the Wnt/beta-catenin signaling pathway, in estrogen-induced neuroprotection and attenuation of tau phosphorylation
    • Zhang Q.G., Wang R., Khan M., Mahesh V., Brann D.W. Role of Dickkopf-1, an antagonist of the Wnt/beta-catenin signaling pathway, in estrogen-induced neuroprotection and attenuation of tau phosphorylation. J. Neurosci. 2008, 28:8430-8441.
    • (2008) J. Neurosci. , vol.28 , pp. 8430-8441
    • Zhang, Q.G.1    Wang, R.2    Khan, M.3    Mahesh, V.4    Brann, D.W.5
  • 92
    • 80052640194 scopus 로고    scopus 로고
    • 17Beta-estradiol regulates insulin-degrading enzyme expression via an ERbeta/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention
    • Zhao L., Yao J., Mao Z., Chen S., Wang Y., Brinton R.D. 17Beta-estradiol regulates insulin-degrading enzyme expression via an ERbeta/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention. Neurobiol. Aging 2011, 32:1949-1963.
    • (2011) Neurobiol. Aging , vol.32 , pp. 1949-1963
    • Zhao, L.1    Yao, J.2    Mao, Z.3    Chen, S.4    Wang, Y.5    Brinton, R.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.