Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease

European Journal of Medicinal Chemistry

Volumn 80, Issue , 2014, Pages 543-561

  Wang, Li ^a   Esteban, Gerard ^b   Ojima, Masaki ^a   Bautista Aguilera, Oscar M ^c   Inokuchi, Tsutomu ^a   Moraleda, Ignacio ^d   Iriepa, Isabel ^d   Samadi, Abdelouahid ^c   Youdim, Moussa B H ^e   Romero, Alejandro ^f   Soriano, Elena ^c   Herrero, Raquel ^g   Fernández Fernández, Ana Patricia ^g   Ricardo Martinez Murillo ^g   Marco Contelles, José ^c   Unzeta, Mercedes ^b  

^a OKAYAMA UNIVERSITY   (Japan)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^d UNIVERSITY OF ALCALÁ   (Spain)

^e TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^f UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^g INSTITUTO CAJAL   (Spain)

Author keywords

Alzheimer's disease; ChE and MAO inhibitors; Fe Cu Zn chelators; In vivo scopolamine induced long term memory deficit; Multifunctional drugs

Indexed keywords

2 (1 BENZYLPIPERIDIN 4 YL) 2 [[(8 HYDROXYQUINOLIN 5 YL)METHYL](PROP 2 YNYL)AMINO]ACETONITRILE; 2 METHYL 5 (3,4,5 TRIMETHOXYBENZAMIDO)DECAHYDROISOQUINOLINE; 3 (1 BENZYLPIPERIDIN 4 YL) 2 [[(8 HYDROXYQUINOLIN 5 YL)METHYL](PROP 2 YNYL)AMINO]PROPANENITRILE; 4 ( 1 BENZYLPIPERIDIN 4 YL) 2 [[(8 HYDROXYQUINOLIN 5 YL)METHYL](PROP 2 YNYL)AMINO]BUTANENITRILE; 5 [[(1 BENZYLPIPERIDIN 4 YL)(PROP 2 YNYL)AMINO]METHYL]QUINOLIN 8 OL; 5 [[(1 BENZYLPIPERIDIN 4 YL)METHYL](PROP 2 YNYL)AMINO]QUINOLIN 8 OL; 5 [[[2 (1 BENZYLPIPERIDIN 4 YL)ETHYL](PROP 2 YNYL)AMINO]METHYL]QUINOLIN 8 OL; 5 [[[3 (1 BENZYLPIPERIDIN 4 YL)PROPYL](PROP 2 YNYL)AMINO]METHYL]QUINOLIN 8 OL; 8 QUINOLINOL DERIVATIVE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; CLORGYLINE; DONEPEZIL; METAL CHELATE; MONOAMINE OXIDASE INHIBITOR; SELEGILINE; UNCLASSIFIED DRUG; ACETYLCHOLINESTERASE; AMINE OXIDASE (FLAVIN CONTAINING); CHELATING AGENT; INDAN DERIVATIVE; PARGYLINE; PIPERIDINE DERIVATIVE; PROPARGYLAMINE; PROPYLAMINE; QUINOLINOL DERIVATIVE;

ALZHEIMER DISEASE; AMINATION; ANIMAL EXPERIMENT; ARTICLE; BRAIN; CELL VIABILITY; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG PENETRATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENANTIOMER; EXPERIMENTAL AMNESIA; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; INTESTINE ABSORPTION; MALE; MDCK CELL LINE; MEMORY DISORDER; MOLECULAR MODEL; MOUSE; NONHUMAN; PASSIVE AVOIDANCE; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DRUG EFFECTS; HEPG2 CELL LINE; MEMORY; METABOLISM; MOLECULAR DOCKING; RAT; TOXICITY;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; ANIMALS; CHELATING AGENTS; CHOLINESTERASE INHIBITORS; HEP G2 CELLS; HUMANS; HYDROXYQUINOLINES; INDANS; MALE; MEMORY; MOLECULAR DOCKING SIMULATION; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PARGYLINE; PIPERIDINES; PROPYLAMINES; RATS;

EID: 84900532421     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.04.078     Document Type: Article

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