Variations in activity and inhibition with pH: The protonated amine is the substrate for monoamine oxidase, but uncharged inhibitors bind better

Journal of Neural Transmission

Volumn 114, Issue 6, 2007, Pages 707-712

  Jones, T Z E ^a   Balsa, D ^b   Unzeta, M ^b   Ramsay, R R ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Kinetics; Monoamine oxidase

Indexed keywords

AMINE; AMINE OXIDASE (FLAVIN CONTAINING); AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; KYNURAMINE; MONOAMINE OXIDASE INHIBITOR; NEUROTRANSMITTER; OXAZOLIDINONE DERIVATIVE; PHENETHYLAMINE; QUERCETIN;

CATALYSIS; CONFERENCE PAPER; ENZYME ACTIVITY; ENZYME INHIBITION; GRANULOCYTE; HUMAN; HUMAN CELL; HYDROPHOBICITY; KINETICS; MOLECULAR DYNAMICS; OXIDATION; OXIDATION REDUCTION REACTION; PH; PRIORITY JOURNAL; PROTEIN BINDING;

BINDING SITES; BIOGENIC AMINES; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVINS; GRANULOCYTES; HUMANS; HYDROGEN-ION CONCENTRATION; KYNURAMINE; MOLECULAR STRUCTURE; MONOAMINE OXIDASE; OXAZOLIDINONES; PHENETHYLAMINES; PROTONS;

EID: 34250811635     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-007-0675-y     Document Type: Conference Paper

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