Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 18, 2004, Pages 4639-4642

  Shao, Dong ^a   Zou, Chunyan ^a   Luo, Cheng ^a   Tang, Xican ^a   Li, Yuanchao ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Acetylcholinesterase inhibitor; Alzheimer's disease; Hybrids; Tacrine E2020

Indexed keywords

CHOLINESTERASE INHIBITOR; DONEPEZIL; TACRINE;

ALZHEIMER DISEASE; ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HYBRID; IN VITRO STUDY; NONHUMAN; RAT;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; ANIMALS; BUTYRYLCHOLINESTERASE; CEREBRAL CORTEX; CHOLINESTERASE INHIBITORS; INDANS; LIGANDS; MODELS, MOLECULAR; NOOTROPIC AGENTS; PIPERIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 8544243477     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.07.005     Document Type: Article

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