Inhibition of monoamine oxidase A and B activities by imidazol(ine)/guanidine drugs, nature of the interaction and distinction from I2-imidazoline receptors in rat liver

British Journal of Pharmacology

Volumn 121, Issue 5, 1997, Pages 901-912

  Ozaita, Andrés ^a   Olmos, Gabriel ^a   Boronat, M Assumpció ^a   Lizcano, José Miguel ^b   Unzeta, Mercedes ^b   García Sevilla, Jesús A ^a  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

3H clonidine; Competitive inhibition; Guanidine drugs; I2 imidazoline receptors; Imidazol(ine); MAO A and MAO B isoforms; Mixed inhibition

Indexed keywords

2 BENZOFURANYL 2 IMIDAZOLINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CIRAZOLINE; CLONIDINE; GUANABENZ; GUANIDINE DERIVATIVE; IDAZOXAN; IMIDAZOLINE DERIVATIVE; IMIDAZOLINE I2 RECEPTOR; LAZABEMIDE; LSL 61112; N (2 AMINOETHYL) 5 (3 FLUOROPHENYL) 4 THIAZOLECARBOXAMIDE; OXYMETAZOLINE; TRACIZOLINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; LIVER; LIVER MITOCHONDRION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CLONIDINE; GUANIDINES; IMIDAZOLES; ISOENZYMES; KINETICS; LIVER; MALE; MITOCHONDRIA, LIVER; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PICOLINIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DRUG; THIAZOLES;

EID: 0030912161     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701214     Document Type: Article

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