Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 17, 2003, Pages 9750-9755

  Binda, Claudia ^a   Li, Min ^b   Hubálek, Frantisek ^b   Restelli, Nadia ^a   Edmondson, Dale E ^b   Mattevi, Andrea ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIPHENYL 2 BUTENE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CYSTEINE; ISATIN; MONOAMINE OXIDASE INHIBITOR; N (2 AMINOETHYL) 4 CHLOROBENZAMIDE; PHENYL GROUP; QUERCETIN; TRANYLCYPROMINE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; HUMAN TISSUE; HYDROGEN BOND; HYDROPHILICITY; LIVER MITOCHONDRION; MITOCHONDRIAL MEMBRANE; OUTER MEMBRANE; OXIDATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

CATALYTIC DOMAIN; COENZYMES; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; FLAVINS; HUMANS; ISATIN; MITOCHONDRIA; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PROTEIN CONFORMATION;

GYMNOMYZA SAMOENSIS;

EID: 0042693016     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1633804100     Document Type: Article

References (23)

1. Binda, C., Newton-Vinson, P., Hubálek, F., Edmondson, D. E. & Mattevi, A. (2002) Nat. Struct. Biol. 9, 22-26.
2. Glover, Y. & Sandler, M. (1993) in Monoamine Oxidase, eds. Uchida, E., Oguchi, K., Kiuchi, Y. & Yasuhara, H. (VSP, Zeist, The Netherlands), pp. 61-71.
3. Hubálek, F., Binda, C., Li, M., Mattevi, A. & Edmondson, D. E. (2003) Acta Crystallogr. D, in press.
4. Cesura, A. M., Gottowik, J., Lahm, H.-W., Lang, G., Imhof, R., Malherbe, P., Röthlisberger, U. & Da Prada, M. (1996) Eur. J. Biochem. 236, 996-1002.
5. Zhong, B. & Silverman, R. B. (1997) J. Am. Chem. Soc. 119, 6690-6691.
6. Paech, C., Salach, J. I. & Singer, T. P. (1980) J. Biol. Chem. 255, 2700-2704.
7. Newton-Vinson, P., Hubálek, F. & Edmondson, D. E. (2000) Protein Expression Purif. 20, 334-345.
8. Leslie, A. G. (1999) Acta Crystallogr. D 55, 1696-1702.
9. Collaborative Computational Project Number 4 (1994) Acta Crystallogr. D 50, 760-767.
10. Murshudov, G. N., Vagin, A. A. & Dodson, E. J. (1997) Acta Crystallogr. D 53, 240-255.
11. Morris, R. J., Perrakis, A. & Lamzin, V. S. (2002) Acta Crystallogr. D 58, 968-975.
12. Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. (1991) Acta Crystallogr. A 47, 110-119.
13. Kastenholz, M. A., Pastor, M., Cruciani, G., Haaksma, E. E. & Fox, T. (2000) J. Med. Chem. 43, 3033-3044.
14. Kleywegt, G. J. & Jones, T. A. (1994) Acta Crystallogr. D 50, 178-185.
15. Wallace, A. C., Laskowski, R. A. & Thornton, J. M. (1995) Protein Eng. 8, 127-134.
16. Esnouf, R. M. (1999) Acta Crystallogr. D 55, 938-940.
17. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.
18. Merritt, E. A. & Bacon, D. J. (1997) Methods Enzymol. 277, 505-524.
19. Sayre, L. M., Singh, M. P., Kokil, P. B. & Wang, F. (1991) J. Org. Chem. 56, 1353-1355.
20. Binda, C., Mattevi, A. & Edmondson, D. E. (2002) J. Biol. Chem. 277, 23973-23976.
21. Herzberg, O. & Moult, J. (1991) Proteins Struct. Funct. Genet. 11, 223-229.
22. Geha, R. M., Chen, K., Wouters, J., Ooms, F. & Shih, J. C. (2002) J. Biol. Chem. 277, 17209-17216.
23. Walker, M. C. & Edmondson, D. E. (1994) Biochemistry 33, 7088-7098.