2H kinetic isotope effects and pH dependence of catalysis as mechanistic probes of rat monoamine oxidase A: Comparisons with the human enzyme

Biochemistry

Volumn 50, Issue 35, 2011, Pages 7710-7717

  Wang, Jin ^a   Edmondson, Dale E ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; BENZYLAMINES; BINDING AFFINITIES; C-H BOND CLEAVAGE; DEUTERIUM KINETIC ISOTOPE EFFECT; DOMINANT CONTRIBUTIONS; ELECTRONIC SUBSTITUENT PARAMETERS; FLAVOENZYMES; FUNCTIONAL PROPERTIES; HUMAN ENZYMES; KINETIC ISOTOPE EFFECTS; MECHANISTIC PROBES; MEMBRANE-BOUND; MONOAMINE OXIDASE A; NUCLEOPHILIC MECHANISMS; PH DEPENDENCE; QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP; RATE LIMITING; STRUCTURE-ACTIVITY; VAN DER WAALS VOLUME;

AUTOMOBILE EXHIBITIONS; BINDING ENERGY; CARRIER MOBILITY; CATALYSIS; DEUTERIUM; ENZYMES; RATS; VAN DER WAALS FORCES;

PH EFFECTS;

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; BENZYLAMINE; DEUTERIUM; HARMAN;

ARTICLE; BINDING AFFINITY; CATALYSIS; COMPETITIVE INHIBITION; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME STABILITY; ENZYME SUBSTRATE; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR PROBE; NONHUMAN; NUCLEOPHILICITY; OXIDATION; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTON TRANSPORT; QUANTITATIVE ANALYSIS; RAT; STEADY STATE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; CATALYSIS; DEUTERIUM; HUMANS; HYDROGEN; HYDROGEN-ION CONCENTRATION; ISOTOPES; MONOAMINE OXIDASE; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; SPECIES SPECIFICITY;

ANIMALIA; RATTUS;

EID: 80052245133     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200951z     Document Type: Article

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