Synthesis and Structure-Activity Relationships of Conformationally Constrained Histamine H3 Receptor Agonists

Journal of Medicinal Chemistry

Volumn 46, Issue 25, 2003, Pages 5445-5457

  Kitbunnadaj, Ruengwit ^a,b   Zuiderveld, Obbe P ^a   De Esch, Iwan J P ^a   Vollinga, Roeland C ^a   Bakker, Remko ^a   Lutz, Martin ^c   Spek, Anthony L ^c   Cavoy, Emile ^d   Deltent, Marie France ^d   Menge, Wiro M P B ^a   Timmerman, Henk ^a   Leurs, Rob ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b NARESUAN UNIVERSITY   (Thailand)

^c UTRECHT UNIVERSITY   (Netherlands)

^d UCB PHARMA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3 (1H IMIDAZOL 5 YL)PROPYLPIPERIDINE; HISTAMINE AGONIST; HISTAMINE DERIVATIVE; HISTAMINE H3 RECEPTOR; HISTAMINE H4 RECEPTOR; IMBUTAMINE; IMMEPIP; PROPYLENE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HUMAN CELL; RECEPTOR AFFINITY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

BINDING, COMPETITIVE; CELL LINE; COLORIMETRY; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; HISTAMINE; HISTAMINE AGONISTS; HISTAMINE ANTAGONISTS; HUMANS; IMIDAZOLES; LIGANDS; MOLECULAR CONFORMATION; PIPERIDINES; PYRROLIDINES; RADIOLIGAND ASSAY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RECEPTORS, HISTAMINE H3; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 10744234014     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030905y     Document Type: Article

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