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Volumn 60, Issue 1, 2001, Pages 8-18

Gemcitabine: Progress in the treatment of pancreatic cancer

a LUDWIG MAXIMILIANS UNIVERSITY (Germany)

Author keywords

Clinical benefit response; Combination therapy; Gemcitabine; Palliative chemotherapy; Pancreatic cancer; Single agent; Tumor marker

Indexed keywords

CISPLATIN; FLUOROURACIL; GEMCITABINE;

ARTICLE; CANCER CHEMOTHERAPY; CANCER PALLIATIVE THERAPY; CANCER PATIENT; CANCER SURVIVAL; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG MEGADOSE; DRUG TOLERABILITY; HUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROGNOSIS;

ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CAMPTOTHECIN; CISPLATIN; CLINICAL TRIALS; DEOXYCYTIDINE; DRUG ADMINISTRATION SCHEDULE; ENZYME INHIBITORS; FLUOROURACIL; HUMANS; MATRIX METALLOPROTEINASES; PACLITAXEL; PALLIATIVE CARE; PANCREATIC NEOPLASMS; SURVIVAL ANALYSIS; TAXOIDS; TREATMENT OUTCOME;

EID: 0035165047 PISSN: 00302414 EISSN: None Source Type: Journal
DOI: 10.1159/000055290 Document Type: Article

Times cited : (144)

References (48)

1
- 0031014450
- Cancer statistics
- (1997) CA Cancer Clin , vol.47 , pp. 5-27
- Parker, S.L.¹ Tong, T.² Bold, S.³ Wingo, P.A.⁴

2
- 0029954462
- Pancreatic carcinoma in perspective: A continuing challenge
- (1996) Cancer , vol.78 , pp. 580-591
- Wanebo, H.J.¹ Vezeridis, M.P.²

3
- 0029943675
- Activity of gemcitabine in patients with advanced pancreatic carcinoma
- (1996) Cancer , vol.78 , pp. 633-638
- Moore, M.¹

4
- 0033559213
- An investigational new drug treatment program for patients with gemcitabine
- (1999) Cancer , vol.85 , pp. 1261-1268
- Storniolo, A.M.¹ Enas, M.H.² Brown, C.A.³ Voi, M.⁴ Rothenberg, M.L.⁵ Schilsky, R.⁶

5
- 0029973785
- A rationale for expanding the endpoints for clinical trials in advanced pancreatic carcinoma
- (1996) Cancer , vol.78 , pp. 627-632
- Rothenberg, M.L.¹ Abbruzzese, J.L.² Moore, M.³ Portenoy, R.K.⁴ Robertson, J.M.⁵ Wanebo, H.J.⁶

6
- 0030015038
- Chemotherapy for pancreatic carcinoma
- (1996) Cancer , vol.78 , pp. 654-663
- Ahlgren, J.D.¹

7
- 0033029525
- A combination of gemcitabine and 5-fluorouracil in advanced pancreatic cancer, a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD)
- (1999) Br J Cancer , vol.80 , pp. 1595-1598
- Cascinu, S.¹ Silva, R.R.² Barni, S.³ Labianca, R.⁴ Frontini, L.⁵ Piazza, E.⁶ Pancera, G.⁷ Giordani, P.⁸ Giuliodori, L.⁹ Pessi, M.A.¹⁰ Fusco, V.¹¹ Luporini, G.¹² Cellerino, R.¹³ Catalano, G.¹⁴

8
- 8244254377
- Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
- (1997) J Clin Oncol , vol.15 , pp. 2403-2413
- Burris, H.A.¹ Moore, M.J.² Andersen, J.³ Green, M.R.⁴ Rothenberg, M.L.⁵ Modiano, M.R.⁶ Cripps, C.⁷ Portenoy, R.K.⁸ Storniolo, A.M.⁹ Tarassoff, P.¹⁰ Nelson, R.¹¹ Dorr, F.A.¹² Stephens, C.D.¹³ Von Hoff, D.D.¹⁴

9
- 8944261362
- A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer
- (1996) Ann Oncol , vol.7 , pp. 347-353
- Rothenberg, M.L.¹ Moore, M.² Cripps, M.C.³ Andersen, J.S.⁴ Portenoy, R.K.⁵ Burris III, H.A.⁶ Green, M.R.⁷ Tarassoff, P.G.⁸ Brown, T.D.⁹ Casper, E.S.¹⁰ Storniolo, A.-M.¹¹ Von Hoff, D.D.¹²

10
- 0029951550
- Tumor markers in patients with pancreatic carcinoma
- (1996) Cancer , vol.78 , pp. 57-62
- Gattani, A.M.¹ Mandeli, J.² Bruckner, H.W.³

11
- 0023851586
- Evaluation of the utility of a radioimmunoassay for serum CA 19-9 levels in patients before and after treatment of carcinoma of the pancreas
- (1988) J Clin Oncol , vol.6 , pp. 462-468
- Glenn, J.¹ Steinberg, W.M.² Kurtzman, S.H.³ Steinberg, S.M.⁴ Sindelar, W.F.⁵

12
- 0028267303
- The prognostic value of preoperative serum levels of CA 19-9 and CEA in patients with pancreatic cancer
- (1994) Br J Cancer , vol.69 , pp. 515-519
- Lundin, J.¹ Roberts, P.J.² Kuusela, P.³ Haglund, C.⁴

13
- 0030273040
- CA 19-9 is an index of response to neoadjuvant chemoradiation therapy in pancreatic cancer
- (1996) Am J Surg , vol.172 , pp. 350-352
- Willett, C.G.¹ Daly, W.J.² Warshaw, A.L.³

14
- 0032780681
- CA 19-9: A predictor of response in pancreatic cancer treated with gemcitabine and cisplatin
- (1999) Anticancer Res , vol.19 , pp. 1-3
- Heinemann, V.¹ Schermuly, M.M.² Stieber, P.³ Schulz, L.⁴ Jüngst, D.⁵ Wilkowski, R.⁶ Schalhorn, A.⁷

15
- 0001588594
- Efficacy of 5-FU + cisplatin (FUP) compared to bolus 5-FU (FU) in advanced pancreatic carcinoma (APC): A randomized trial from the French Anticancer Centers Digestive Group (FNLCCDG)
- abstract 1050
- (1999) Proc Am Soc Clin Oncol , vol.18
- Rougier, P.¹ Ducreux, M.² Douillard, J.Y.³ Seitz, J.F.⁴ Bugat, R.⁵ Bosset, J.F.⁶ Merouche, Y.⁷ Raoul, J.L.⁸ Ychou, M.⁹ Adenis, A.¹⁰ Cvitkovic Bertheau, F.¹¹ Luboinski, M.¹² Pignon, J.P.¹³

16
- 0025360261
- A phase III trial on the therapy of advanced pancreatic carcinoma
- (1990) Cancer , vol.65 , pp. 2207-2212
- Cullinan, S.¹ Moertel, C.G.² Wieand, H.S.³ Schutt, A.J.⁴ Krook, J.E.⁵ Foley, J.F.⁶ Norris, B.N.⁷ Kardinal, C.G.⁸ Tschetter, L.K.⁹ Barlow, J.F.¹⁰

17
- 0023783698
- Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluoro-2′-deoxycytidine and 1-βD-arabinofuranosylcytosine
- (1988) Cancer Res , vol.48 , pp. 4024-4031
- Heinemann, V.¹ Hertel, L.W.² Grindey, G.B.³ Plunkett, W.⁴

18
- 0030049697
- Phase II study of gemcitabine in patients with advanced pancreatic cancer
- (1995) Br J Cancer , vol.73 , pp. 101-105
- Carmichael, J.¹ Fink, U.² Russell, R.C.G.³ Spittle, M.F.⁴ Harris, A.L.⁵ Spiessl, G.⁶ Blatter, J.⁷

19
- 0028292341
- Phase II trial of gemcitabine (2′,2′-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas
- (1994) Invest New Drugs , vol.12 , pp. 29-34
- Casper, E.S.¹ Green, M.R.² Kelsen, D.P.³ Heelan, R.T.⁴ Brown, T.D.⁵ Flombaum, C.D.⁶ Trochanowski, B.⁷ Tarassoff, P.G.⁸

20
- 0031025090
- Maximum-tolerated dose defined for single-agent gemcitabine: A phase I dose-escalation study in chemotherapy-naive patients with advanced non-small-cell lung cancer
- (1997) J Clin Oncol , vol.15 , pp. 310-316
- Fossella, F.V.¹ Lippman, S.M.² Shin, D.M.³ Tarassoff, P.⁴ Calayag-Jung, M.⁵ Perez-Soler, R.⁶ Lee, J.S.⁷ Murphy, W.K.⁸ Glisson, B.⁹ Rivera, E.¹⁰ Hong, W.K.¹¹

21
- 0003068332
- Phase II trial of high-dose gemcitabine in patients with metastatic pancreatic adenocarcinoma
- (1999) Onkologie , vol.22 , Issue.SUPPL. 1 , pp. 81
- Pur, H.U.¹ Kornek, G.V.² Raderer, M.³ Fiebiger, W.⁴ Zickero, G.⁵ Pidlich, J.⁶ Greul, R.⁷ Schneeweiss, B.⁸ Depisch, D.⁹ Scheithauer, W.¹⁰

22
- 0000025839
- Randomised phase II trial of dose intense gemcitabine by standard infusion vs. fixed dose rate in metastatic pancreatic adenocarcinoma
- abstract 1048
- (1999) Proc Am Soc Clin Oncol , vol.18 , pp. 273
- Tempero, M.¹ Plunkett, W.² Ruiz van Harperen, V.³ Hainsworth, J.⁴ Hochster, H.⁵ Lenzi, R.⁶ Abbruzzese, J.⁷

23
- 0029584109
- Preclinical characteristics of gemcitabine
- (1995) Anticancer Drugs , vol.6 , pp. 7-13
- Plunkett, W.¹ Huang, P.² Gandhi, V.³

24
- 0000106419
- Synergistic interaction between cisplatin and gemcitabine in ovarian and colon cancer cell lines
- (1995) Purine and Pyrimidine Metabolism in Man , vol.7 , pp. 139-143
- Bergman, A.M.¹ Ruiz van Haperen, V.W.T.² Veerman, G.³ Kuiper, C.M.⁴ Peters, G.J.⁵

25
- 0028839329
- Radiosensitization of human tumor cells by gemcitabine in vitro
- (1995) Semin Oncol , vol.22 , Issue.SUPPL. 11 , pp. 68-71
- Shewach, D.S.¹ Lawrence, T.S.²

26
- 0027234993
- Activity of cisplatin in adenocarcinoma of the pancreas
- (1993) Eur J Cancer , vol.29 A , pp. 203-204
- Wils, J.A.¹ Kok, T.² Wagener, D.J.Th.³ Selleslags, J.⁴ Duez, N.⁵

27
- 0001461012
- Gemcitabine and cisplatin in the treatment of advanced and metastatic pancreatic cancer. Final results of a phase II study
- abstract 1052
- (1999) Proc Am Soc Clin Oncol , vol.18 , pp. 274
- Heinemann, V.¹ Wilke, H.² Possinger, K.³ Mergenthaler, H.-G.⁴ Clemens, M.⁵ König, H.J.⁶ Illiger, H.J.⁷ Ohnmacht, U.⁸ Arning, M.⁹ Schalhorn, A.¹⁰ Fink, U.¹¹

28
- 0000115916
- Phase II study of gemcitabine and cisplatin in advanced or metastatic pancreatic cancer
- abstract 1053
- (1999) Proc Am Soc Clin Oncol , vol.18 , pp. 274
- Philip, P.A.¹ Zalupski, M.² Vaitkevicius, V.K.³ Arlauskas, P.⁴ Shields, A.⁵

29
- 0000575676
- Randomized trial of gemcitabine (GEM) alone or with cisplatin (CDDP) in the treatment of advanced pancreatic cancer (APC): A phase II multicenter study of the Southern Italy Oncology Group
- abstract 961
- (1999) Proc Am Soc Clin Oncol , vol.18 , pp. 250
- Colucci, G.¹ Riccardi, F.² Giuliani, F.³ Lopez, M.⁴ Gebbia, V.⁵ Uomo, M.⁶ Biglietto Mcigolari, S.⁷ Borsellino, N.⁸ Paoletti, G.⁹ Maiello, E.¹⁰ Gebbia, N.¹¹

30
- 0000327536
- Phase II trial of the use of gemcitabine and 5-fluorouracil in the treatment of advanced pancreatic and biliary tract adenocarcinoma
- abstract 1116
- (1998) Proc Am Soc Clin Oncol , vol.17
- De Gusmao, C.B.R.A.¹ Murad, A.M.² Scalabrini-Neto, A.M.³

31
- 0033012340
- Phase I-II study of gemcitabine and fluorouracil as a continuous infusion in patients with pancreatic cancer
- (1999) J Clin Oncol , vol.17 , pp. 585-592
- Hidalgo, M.¹ Castellano, D.² Paz-Ares, L.³ Gravalos, C.⁴ Diaz-Puente, M.⁵ Hitt, R.⁶ Alonso, S.⁷ Cortes-Funes, H.⁸

32
- 0000407910
- Phase II trial with gemcitabine (GEM) + 5-fluorouracil (5-FU) in advanced pancreatic cancer (APC)
- abstract 1110
- (2000) Proc Am Soc Clin Oncol , vol.19
- Pastorelli, D.¹ Peddrazoli, S.² Sperti, C.³ Vicario, G.⁴ Scelzi, E.⁵ Santarossa, S.⁶ Sgarbossa, G.⁷ Fosser, V.⁸ Manente, P.⁹

33
- 0003200037
- Phase II study of gemcitabine (G) and continuous intravenous infusion (CIV) 5-fluorouracil (5-FU) in advanced pancreatic cancer (PC): A University of Chicago phase II consortium study
- abstract 1126
- (2000) Proc Am Soc Clin Oncol , vol.19
- Schulman, K.L.¹ Kindler, H.L.² Lad, T.E.³ Reilly, K.⁴ Mani, S.⁵ Vokes, E.E.⁶

34
- 0001317902
- Phase I-II study of gemcitabine in combination with 24 hours continuous infusion (CI) of 5-fluorouracil 5-FU) and L-leucovorin (LV) in patients (pts) with advanced pancreatic carcinoma
- abstract 1235
- (2000) Proc Am Soc Clin Oncol , vol.19
- Lencioni, M.¹ Falcone, A.² Masi, G.³ Fioretto, L.⁴ Meucci, I.⁵ Di Marsico, R.⁶ Pfanner, E.⁷ Galli, C.⁸ Bonifazi, V.⁹ Mazzocchi, B.¹⁰ Tognarini, L.¹¹ Conte, P.¹²

35
- 0000128087
- Multi-center phase II study in advanced pancreatic adenocarcinoma patients treated with a combination of leucovorin, 5-FU bolus and infusion, and gemcitabine (FOLFUGEM regimen)
- abstract 1054
- (1999) Proc Am Soc Clin Oncol , vol.18
- Louvet, C.¹ Hammel, P.² Andre, T.³ Vanica, R.⁴ Landi, B.⁵ Balosso, J.⁶ Cattan, S.⁷ Fonck, M.⁸ Flesch, M.⁹ Colin, P.¹⁰ Gruson, T.¹¹ De Gramont, A.¹²

36
- 0006604588
- High-dose 5-fluorouracil (FU) 24-hour-infusion with gemcitabine (GEM): Tolerable and efficient in palliative outpatient treatment of pancreatic cancer
- abstract 1248
- (2000) Proc Am Soc Clin Oncol , vol.19
- Riedel, C.¹ Wein, A.² Wehler, M.³ Lampert, S.⁴ Fischer, B.⁵ Hohenberger, W.⁶ Hahn, E.⁷ Schneider, T.⁸

37
- 0000901075
- Phase II study of gemcitabine (GEM) and weekly 48-hour continuous infusion (CI) high dose 5-fluorouracil (5-FU) in advanced exocrine pancreatic cancer (APC)
- abstract 1145
- (1999) Proc Am Soc Clin Oncol , vol.18
- Rodriguez-Lescure, A.¹ Carrato, A.² Massuti, B.³ Garcia-Gomez, J.⁴ Herrero, J.⁵ Gallego, J.⁶ Diaz-Fernandez, N.⁷ Gonzalvez, M.L.⁸

38
- 0006591108
- Definitive results of a phase II trial PEF-G (cisplatin, epirubicin, 5-fluorouracil continuous infusion, gemcitabine) in stage IV pancreatic adenocarcinoma
- abstract 1019
- (2000) Proc Am Soc Clin Oncol , vol.19
- Reni, M.¹ Passoni, P.² Villa, E.³

39
- 0003357550
- Phase I/II study in advanced pancreatic adenocarcinoma (APA) and carcinoma of unknown primary (CUP): A combination of leucovorin (LV), 5-FU bolus and infusion, gemcitabine (GEM), and oxaliplatin (L.OHP) (FOLFU GEMOX Regimen)
- abstract 913
- (2000) Proc Am Soc Clin Oncol , vol.19
- Mousseau, M.¹ Rebischung, C.² Garnier, C.³ Chirpaz, E.⁴ Provencal, J.⁵ Papillon, E.⁶ Balosso, J.⁷ Charlety, D.⁸ Lemoigne, A.⁹ Pasquier, D.¹⁰ Schaerer, R.¹¹ Esterni, J.¹²

40
- 0000421620
- Multicenter phase II trial of first-line irinotecan and gemcitabine (Irinogem) in patients with locally advanced or metastatic pancreatic cancer (PC)
- abstract 1023
- (2000) Proc Am Soc Clin Oncol , vol.19 , pp. 263
- Rocha Lima, C.¹ Savarese, D.² Bruchner, H.³ Dudek, A.⁴ Echardt, J.⁵ Hainsworth, J.⁶ Lester, E.⁷ Compton, L.⁸ Locker, P.⁹ Elfring, G.¹⁰ Miller, L.¹¹ Green, M.¹²

41
- 0000421614
- Front-line treatment of pancreatic carcinoma with gemcitabine (GMB) in combination with irinotecan (CPT-11): Preliminary results of a multicenter phase II study
- abstract 1260
- (2000) Proc Am Soc Clin Oncol , vol.19
- Stathopoulos, G.¹ Rigatos, G.² Dimopoulos, M.³ Kouroussis, C.⁴ Panopoulos, C.⁵ Giannakakis, T.⁶ Tzanninis, D.⁷ Georgoulias, V.⁸

42
- 0006526970
- Final results of a phase I study of weekly gemcitabine and docetaxel in pancreatic carcinoma and preliminary results of a phase II study
- abstract 1256
- (2000) Proc Am Soc Clin Oncol
- Ridwelski, K.¹ Kettner, E.² Florschütz, A.³ Klein, U.⁴ Eichelmann, K.⁵ Lippert, H.⁶

43
- 0001317899
- A phase I/II study of gemcitabine (G) and docetaxel (D) in patients (pts) with unresectable pancreatic cancer
- abstract 1032
- (2000) Proc Am Soc Clin Oncol , vol.19 , pp. 288
- Jacobs, A.D.¹ Otero, H.² Picozzi V., Jr.³ Aboulafia, D.M.⁴ Weiden, P.L.⁵

44
- 0000667913
- Phase II study of gemcitabine and docetaxel in patients with metastatic pancreatic cancer
- abstract 1238
- (2000) Proc Am Soc Clin Oncol , vol.19
- Clark, J.W.¹ Ryan, D.P.² Kulke, M.H.³ Grossbard, M.L.⁴ Fuchs, C.S.⁵ Grossman, S.R.⁶ Morgan, J.A.⁷ Earle, C.C.⁸ Shivdasani, R.⁹ Grenon, N.¹⁰ Berg, D.¹¹ Mayer, R.J.¹²

45
- 0033999308
- Matrix metalloproteinases: Biologic activity and clinical implications
- (2000) J Clin Oncol , vol.18 , pp. 1135-1149
- Nelson, A.R.¹ Fingleton, B.² Rothenberg, M.L.³ Matrisian, L.M.⁴

46
- 0000632527
- Phase IB study of concurrent administration of marimastat and gemcitabine in non-resectable pancreatic cancer
- abstract 888
- (1998) Proc Am Soc Clin Oncol , vol.17 , pp. 232
- Carmichael, J.¹ Ledermann, J.A.² Woll, P.J.³ Gulliford, T.⁴ Russel, R.C.⁵

47
- 0000511054
- A randomized study comparing marimastat to gemcitabine as first line therapy in patients with non-resectable pancreatic cancer
- abstract 1005
- (1999) Proc Am Soc Clin Oncol , vol.18 , pp. 261
- Rosemurgy, A.¹ Buckels, J.² Charnley, R.³ Winston, R.⁴ Steward, W.⁵ Staddon, A.⁶ Curtis, L.⁷ Rugg, T.⁸ Rasmussen, H.⁹

48
- 0006527224
- Release date, 2/15/99
- Results of marimastat study 128: Pancreatic cancer monotherapy trial

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