SCOPUS 정보 검색 플랫폼

Volumn 21, Issue 4, 2013, Pages 903-911

Probing the steric requirements of the γ-aminobutyric acid aminotransferase active site with fluorinated analogues of vigabatrin

(4) Juncosa Jr , Jose I a Groves, Andrew P a Xia, Guoyao a Silverman, Richard B a

a NORTHWESTERN UNIVERSITY (United States)

Author keywords

Aminobutyric acid aminotransferase; 4 Amino 5 fluoropentanoic acid; Enzyme inhibition; Molecular dynamics; Vigabatrin

Indexed keywords

1 (5 OXOTETRAHYDROFURAN 2 YL)ETHYL 4 NITROBENZOATE; 4 AMINO 5 FLUOROHEXANOIC ACID DERIVATIVE; 4 AMINO 5 FLUOROPENTANOIC ACID DERIVATIVE; 4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMMONIO 5 FLUOROHEXANOATE; 4,5 BENZYL 4 AZIDO 5 FLUOROHEXANOATE; 4,5 BENZYL 5 FLUORO 4 HYDROXYHEXANOATE; 5 (1 FLUOROETHYL)DIHYDROFURAN 2(3H) ONE; 5 (1 FLUOROETHYL)DIHYDROFURAN 2(3H)ONE; 5 (1 HYDROXYETHYL)DIHYDROFURAN 2(3H) ONE; 5 (1 HYDROXYETHYL)DIHYDROFURAN 2(3H)ONE; 5 FLUORO 4 (3,3,3 TRIFLUORO 2 METHOXY 2 PHENYLPROPANAMIDO)HEXANOIC ACID; ETHYL HEX 4 ENOATE; HEXANOIC ACID DERIVATIVE; UNCLASSIFIED DRUG; VIGABATRIN;

ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; FLUORINATION; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

4-AMINOBUTYRATE TRANSAMINASE; ANTICONVULSANTS; BINDING SITES; CATALYTIC DOMAIN; FLUORINE; GAMMA-AMINOBUTYRIC ACID; MOLECULAR DOCKING SIMULATION; VIGABATRIN;

EID: 84873292163 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.12.009 Document Type: Article

Times cited : (17)

References (27)

1
- 71449100040
- J.A. Tolman, and M.A. Faulkner Expert Opin. Pharmacother. 10 2009 3077
- (2009) Expert Opin. Pharmacother. , vol.10 , pp. 3077
- Tolman, J.A.¹ Faulkner, M.A.²

2
- 0026347939
- S.M. Nanavati, and R.B. Silverman J. Am. Chem. Soc. 113 1991 9341
- (1991) J. Am. Chem. Soc. , vol.113 , pp. 9341
- Nanavati, S.M.¹ Silverman, R.B.²

3
- 0037114069
- E.L. Gardner, W.K. Schiffer, B.A. Horan, D. Highfield, S.L. Dewey, J.D. Brodie, and C.R. Ashby Jr. Synapse 46 2002 240
- (2002) Synapse , vol.46 , pp. 240
- Gardner, E.L.¹ Schiffer, W.K.² Horan, B.A.³ Highfield, D.⁴ Dewey, S.L.⁵ Brodie, J.D.⁶ Ashby, Jr.C.R.⁷

4
- 59949094486
- A. DeMarco, R.M. Dalal, J. Pai, S.D. Aquilina, U. Mullapudi, C. Hammel, S.K. Kothari, M. Kahanda, C.N. Liebling, V. Patel, W.K. Schiffer, J.D. Brodie, and S.L. Dewey Synapse 63 2009 87
- (2009) Synapse , vol.63 , pp. 87
- Demarco, A.¹ Dalal, R.M.² Pai, J.³ Aquilina, S.D.⁴ Mullapudi, U.⁵ Hammel, C.⁶ Kothari, S.K.⁷ Kahanda, M.⁸ Liebling, C.N.⁹ Patel, V.¹⁰ Schiffer, W.K.¹¹ Brodie, J.D.¹² Dewey, S.L.¹³

5
- 0035452407
- M. Paul, S.L. Dewey, E.L. Gardner, J.D. Brodie, and C.R. Ashby Jr. Synapse 41 2001 219
- (2001) Synapse , vol.41 , pp. 219
- Paul, M.¹ Dewey, S.L.² Gardner, E.L.³ Brodie, J.D.⁴ Ashby, Jr.C.R.⁵

6
- 0022972790
- R.B. Silverman, and B.J. Invergo Biochemistry 25 1986 6817
- (1986) Biochemistry , vol.25 , pp. 6817
- Silverman, R.B.¹ Invergo, B.J.²

7
- 0020597703
- R.B. Silverman, A.J. Muztar, M.A. Levy, and J.D. Hirsch Life Sci. 32 1983 2717
- (1983) Life Sci. , vol.32 , pp. 2717
- Silverman, R.B.¹ Muztar, A.J.² Levy, M.A.³ Hirsch, J.D.⁴

8
- 0025316471
- M.J. Neal, and M.A. Shah Br. J. Pharmacol. 100 1990 324
- (1990) Br. J. Pharmacol. , vol.100 , pp. 324
- Neal, M.J.¹ Shah, M.A.²

9
- 0030070864
- H. Okumura, M. Omote, and S. Takeshita Arzneimittel-Forschung 46 1996 459
- (1996) Arzneimittel-Forschung , vol.46 , pp. 459
- Okumura, H.¹ Omote, M.² Takeshita, S.³

10
- 80051704092
- Y. Adachi, N. Kamei, S. Yokoshima, and T. Fukuyama Org. Lett. 13 2011 4446
- (2011) Org. Lett. , vol.13 , pp. 4446
- Adachi, Y.¹ Kamei, N.² Yokoshima, S.³ Fukuyama, T.⁴

11
- 29044438185
- E. Bourque, P.J. Kocienski, M. Stocks, and J. Yuen Synthesis 2005 3219
- (2005) Synthesis , pp. 3219
- Bourque, E.¹ Kocienski, P.J.² Stocks, M.³ Yuen, J.⁴

12
- 0033515856
- T. Sammakia, and J.S. Jacobs Tetrahedron Lett. 40 1999 2685
- (1999) Tetrahedron Lett. , vol.40 , pp. 2685
- Sammakia, T.¹ Jacobs, J.S.²

13
- 0033523938
- J. Qiu, J.M. Pingsterhaus, and R.B. Silverman J. Med. Chem. 42 1999 4725
- (1999) J. Med. Chem. , vol.42 , pp. 4725
- Qiu, J.¹ Pingsterhaus, J.M.² Silverman, R.B.³

14
- 0347052772
- P. Storici, D. De Biase, F. Bossa, S. Bruno, A. Mozzarelli, C. Peneff, R.B. Silverman, and T. Schirmer J. Biol. Chem. 279 2004 363
- (2004) J. Biol. Chem. , vol.279 , pp. 363
- Storici, P.¹ De Biase, D.² Bossa, F.³ Bruno, S.⁴ Mozzarelli, A.⁵ Peneff, C.⁶ Silverman, R.B.⁷ Schirmer, T.⁸

15
- 0141712450
- K.B. Sharpless, W. Amberg, Y.L. Bennani, G.A. Crispino, J. Hartung, K.S. Jeong, H.L. Kwong, K. Morikawa, and Z.M. Wang J. Org. Chem. 57 1992 2768
- (1992) J. Org. Chem. , vol.57 , pp. 2768
- Sharpless, K.B.¹ Amberg, W.² Bennani, Y.L.³ Crispino, G.A.⁴ Hartung, J.⁵ Jeong, K.S.⁶ Kwong, H.L.⁷ Morikawa, K.⁸ Wang, Z.M.⁹

16
- 84873300984
- Schrödinger, LLC
- The PyMOL Molecular Graphics System, Version 1.4.1. Schrödinger, LLC.
- The PyMOL Molecular Graphics System, Version 1.4.1

17
- 33947716119
- R. Huey, G.M. Morris, A.J. Olson, and D.S. Goodsell J. Comput. Chem. 28 2007 1145
- (2007) J. Comput. Chem. , vol.28 , pp. 1145
- Huey, R.¹ Morris, G.M.² Olson, A.J.³ Goodsell, D.S.⁴

18
- 70349932423
- G.M. Morris, R. Huey, W. Lindstrom, M.F. Sanner, R.K. Belew, D.S. Goodsell, and A.J. Olson J. Comput. Chem. 30 2009 2785
- (2009) J. Comput. Chem. , vol.30 , pp. 2785
- Morris, G.M.¹ Huey, R.² Lindstrom, W.³ Sanner, M.F.⁴ Belew, R.K.⁵ Goodsell, D.S.⁶ Olson, A.J.⁷

19
- 34247343346
- A.N. Jain J. Comput. Aided Mol. Des. 21 2007 281
- (2007) J. Comput. Aided Mol. Des. , vol.21 , pp. 281
- Jain, A.N.¹

20
- 84864245094
- 1699 South Hanley Rd., St. Louis, MO 63144, USA
- SYBYL 8.0, Tripos International, 1699 South Hanley Rd., St. Louis, MO 63144, USA.
- SYBYL 8.0, Tripos International

21
- 46249092554
- B. Hess, C. Kutzner, D. van der Spoel, and E. Lindahl J. Chem. Theory Comput. 4 2008 435
- (2008) J. Chem. Theory Comput. , vol.4 , pp. 435
- Hess, B.¹ Kutzner, C.² Van Der Spoel, D.³ Lindahl, E.⁴

22
- 77955309392
- M. Valiev, E.J. Bylaska, N. Govind, K. Kowalski, T.P. Straatsma, H.J.J. Van Dam, D. Wang, J. Nieplocha, E. Apra, T.L. Windus, and W. de Jong Comput. Phys. Commun. 181 2010 1477
- (2010) Comput. Phys. Commun. , vol.181 , pp. 1477
- Valiev, M.¹ Bylaska, E.J.² Govind, N.³ Kowalski, K.⁴ Straatsma, T.P.⁵ Van Dam, H.J.J.⁶ Wang, D.⁷ Nieplocha, J.⁸ Apra, E.⁹ Windus, T.L.¹⁰ De Jong, W.¹¹

23
- 79959999377
- E. Vanquelef, S. Simon, G. Marquant, E. Garcia, G. Klimerak, J.C. Delepine, P. Cieplak, and F.Y. Dupradeau Nucleic Acids Res. 39 2011 W511
- (2011) Nucleic Acids Res. , vol.39 , pp. 511
- Vanquelef, E.¹ Simon, S.² Marquant, G.³ Garcia, E.⁴ Klimerak, G.⁵ Delepine, J.C.⁶ Cieplak, P.⁷ Dupradeau, F.Y.⁸

24
- 33748538349
- J.M. Wang, W. Wang, P.A. Kollman, and D.A. Case J. Mol. Graph. Model. 25 2006 247
- (2006) J. Mol. Graph. Model. , vol.25 , pp. 247
- Wang, J.M.¹ Wang, W.² Kollman, P.A.³ Case, D.A.⁴

25
- 0019876595
- J.E. Churchich, and U. Moses J. Biol. Chem. 256 1981 1101
- (1981) J. Biol. Chem. , vol.256 , pp. 1101
- Churchich, J.E.¹ Moses, U.²

26
- 84965093141
- E.M. Scott, and W.B. Jakoby J. Biol. Chem. 234 1959 932
- (1959) J. Biol. Chem. , vol.234 , pp. 932
- Scott, E.M.¹ Jakoby, W.B.²

27
- 45549111632
- D. Jeffery, P.D.J. Weitzman, and G.G. Lunt Insect Biochem. 18 1988 347
- (1988) Insect Biochem. , vol.18 , pp. 347
- Jeffery, D.¹ Weitzman, P.D.J.² Lunt, G.G.³

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