Design, synthesis and antiepileptic properties of novel 1-(substituted benzylidene)-3-(1-(morpholino/piperidino methyl)-2,3-dioxoindolin-5-yl)urea derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 12, 2011, Pages 6057-6065

  Prakash, Chinnasamy Rajaram ^a   Raja, Sundararajan ^b  

^a JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

^b GITAM UNIVERSITY   (India)

Author keywords

Epilepsy; In vivo studies; Isatin; Neurotoxicity

Indexed keywords

1 (2 CHLOROBENZYLIDENE) 3 [1 (MORPHOLINOMETHYL) 2,3 DIOXOINDOLIN 5 YL]UREA; 1 (2 CHLOROBENZYLIDENE) 3 [2,3 DIOXO 1 (PIPERIDIN 1 YLMETHYL)INDOLIN 5 YL]UREA; 1 (3 NITROBENZYLIDENE) 3 [1 (MORPHOLINOMETHYL) 2,3 DIOXOINDOLIN 5 YL]UREA; 1 (3 NITROBENZYLIDENE) 3 [2,3 DIOXO 1 (PIPERIDIN 1 YLMETHYL)INDOLIN 5 YL]UREA; 1 (4 BROMOBENZYLIDENE) 3 [1 (MORPHOLINOMETHYL) 2,3 DIOXOINDOLIN 5 YL]UREA; 1 (4 BROMOBENZYLIDENE) 3 [2,3 DIOXO 1 (PIPERIDIN 1 YLMETHYL)INDOLIN 5 YL]UREA; 1 (4 CHLOROBENZYLIDENE) 3 [1 (MORPHOLINOLMETHYL) 2,3 DIOXOINDOLIN 5 YL]UREA; 1 (4 CHLOROBENZYLIDENE) 3 [2,3 DIOXO 1 (PIPERIDIN 1 YLMETHYL)INDOLIN 5 YL]UREA; 1 (4 FLUOROBENZYLIDENE) 3 [1 (MORPHOLINOMETHYL) 2,3 DIOXOINDOLIN 5 YL]UREA; 1 (4 FLUOROBENZYLIDENE) 3 [2,3 DIOXO 1 (PIPERIDIN 1 YLMETHYL)INDOLIN 5 YL]UREA; 1 (4 HYDROXYBENZYLIDENE) 3 [1 (MORPHOLINOMETHYL) 2,3 DIOXOINDOLIN 5 YL]UREA; 1 (4 HYDROXYBENZYLIDENE) 3 [2,3 DIOXO 1 (PIPERIDIN 1 YLMETHYL)INDOLIN 5 YL]UREA; 1 (4 METHOXYBENZYLIDENE) 3 [1 MORPHOLINOMETHYL) 1,2 DIOXOINDOLIN 5 YL]UREA; 1 (4 METHOXYBENZYLIDENE) 3 [2,3 DIOXO 1 (PIPERIDIN 1 YLMETHYL)INDOLIN 5 YL]UREA; 1 (4 METHYLBENZYLIDENE) 3 [1 (MORPHOLINOMETHYL) 2,3 DIOXOINDOLIN 5 YL]UREA; 1 (4 METHYLBENZYLIDENE) 3 [2,3 DIOXO 1 (PIPERIDIN 1 YLMETHYL)INDOLIN 5 YL]UREA; 1 (4 NITROBENZYLIDENE) 3 [1 (MORPHOLINOMETHYL) 2,3 DIOXOINDOLIN 5 YL]UREA; 1 (4 NITROBENZYLIDENE) 3 [2,3 DIOXO 1 (PIPERIDIN 1 YLMETHYL)INDOLIN 5 YL]UREA; 1 BENZYLIDENE 3 [1 (MORPHOLINOMETHYL) 2,3 DIOXOINDOLIN 5 YL]UREA; 1 BENZYLIDENE 3 [2,3 DIOXO1 (PIPERIDIN 1 YLMETHYL)INDOLIN 5 YL]UREA; ANTICONVULSIVE AGENT; BENZYLIDENE DERIVATIVE; ETHOSUXIMIDE; PHENYTOIN; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC SHOCK; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; RAT; ROTAROD TEST; SEIZURE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTICONVULSANTS; ELECTROSHOCK; EPILEPSY; HUMANS; ISATIN; MALE; MICE; MORPHOLINOS; PIPERIDINES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 80955137560     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.10.020     Document Type: Article

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