Bioactivation of lamotrigine in vivo in rat and in vitro in human liver microsomes, hepatocytes, and epidermal keratinocytes: Characterization of thioether conjugates by liquid chromatography/mass spectrometry and high field nuclear magnetic resonance spectroscopy

Chemical Research in Toxicology

Volumn 23, Issue 1, 2010, Pages 159-170

  Chen, Hao ^a   Grover, Scott ^a   Yu, Linning ^a   Walker, Gregory ^a   Mutlib, Abdul ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CYSTEINE CONJUGATE; CYSTEINYLGLYCINE; CYTOCHROME P450 2A6; CYTOCHROME P450 2C11; DRUG METABOLITE; EPOXIDE; GLUTATHIONE; LAMOTRIGINE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; SULFIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE; CELL FRACTIONATION; CONJUGATE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG STRUCTURE; ENZYME ACTIVATION; EPIDERMIS CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER MICROSOME; MALE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; SKIN CELL; SKIN MANIFESTATION;

ADMINISTRATION, ORAL; ANIMALS; ANTICONVULSANTS; ARYL HYDROCARBON HYDROXYLASES; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GLUTATHIONE; HEPATOCYTES; HUMANS; KERATINOCYTES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICROSOMES, LIVER; MOLECULAR CONFORMATION; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEROID 16-ALPHA-HYDROXYLASE; SULFIDES; TRIAZINES;

RATTUS;

EID: 75149197657     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx9003243     Document Type: Article

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