Synthesis and anticonvulsant activity of bioisosteres of trimethadione, N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides from α-hydroxyamides

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 4, 2013, Pages 841-846

  Pastore, Valentina ^a,b   Sabatier, Laureano ^a   Enrique, Andrea ^a   Marder, Mariel ^b   Bruno Blanch, Luis E ^a  

^a UNIVERSIDAD NACIONAL DE LA PLATA   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Hydroxyamides; Anticonvulsant screening; Microwave synthesis; N derivative 1,2,3 oxathiazolidine 4 one 2,2 dioxides

Indexed keywords

1,2,3 OXATHIAZOLIDINE 4 ONE 2,2 DIOXIDE DERIVATIVE; 3 BENZYL 5,5 DIMETHYL 1,2,3 OXATHIAZOLIDINE 4 ONE 2,2 DIOXIDE; 3 BUTYL 5,5 DIMETHYL 1,2,3 OXATHIAZOLIDINE 4 ONE 2,2 DIOXIDE; 3 PHENETHYL 5,5 DIMETHYL 1,2,3 OXATHIAZOLIDINE 4 ONE 2,2 DIOXIDE; 3 PROPYL 5,5 DIMETHYL 1,2,3 OXATHIAZOLIDINE 4 ONE 2,2 DIOXIDE; ALPHA HYDROXYAMIDE DERIVATIVE; AMIDE; N BENZYL 2 HYDROXYISOBUTYLAMIDE; N BUTYL 2 HYDROXYISOBUTYLAMIDE; N BUTYL 2,2 DIPHENYL 2 HYDROXYACETAMIDE; N CYCLOHEXYL 2 HYDROXYISOBUTYLAMIDE; N PHENETHYL 2 HYDROXYISOBUTYLAMIDE; N PROPYL 2 HYDROXYISOBUTYLAMIDE; OXAZOLIDINE DERIVATIVE; TRIMETHADIONE; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; ROTAROD TEST; SEIZURE;

AMIDES; ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; MALE; MICE; MICROWAVES; PHENYTOIN; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES; TRIMETHADIONE;

MUS;

EID: 84873317261     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.12.033     Document Type: Article

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