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Volumn 16, Issue 7, 2007, Pages 636-644

Timed pentylenetetrazol infusion test: A comparative analysis with s.c.PTZ and MES models of anticonvulsant screening in mice

Author keywords

Antiepileptic drugs; Epilepsy; i.v. pentylenetetrazol; Mice

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; DIAZEPAM; ETHOSUXIMIDE; ETIRACETAM; GABAPENTIN; LAMOTRIGINE; OXCARBAZEPINE; PENTETRAZOLE; PHENOBARBITAL; PHENYTOIN; PREGABALIN; TIAGABINE; TOPIRAMATE; VALPROIC ACID; ZONISAMIDE;

EID: 34548165281     PISSN: 10591311     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.seizure.2007.05.005     Document Type: Article
Times cited : (156)

References (41)
  • 1
    • 30144443464 scopus 로고    scopus 로고
    • Molecular target versus models for new antiepileptic drug discovery
    • Rogawski M.A. Molecular target versus models for new antiepileptic drug discovery. Epilepsy Res 68 (2006) 22-28
    • (2006) Epilepsy Res , vol.68 , pp. 22-28
    • Rogawski, M.A.1
  • 2
    • 0034864170 scopus 로고    scopus 로고
    • Animal models used in the screening of antiepileptic drugs
    • Kupferberg H. Animal models used in the screening of antiepileptic drugs. Epilepsia 42 Suppl. 4 (2001) 7-12
    • (2001) Epilepsia , vol.42 , Issue.SUPPL. 4 , pp. 7-12
    • Kupferberg, H.1
  • 3
    • 0347364701 scopus 로고    scopus 로고
    • Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: summary of the NIH/NINDS/AES models II workshop
    • Stables J.P., Bertram E., Dudek F.E., Holmes G., Mathern G., Pitkanen A., et al. Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: summary of the NIH/NINDS/AES models II workshop. Epilepsia 44 (2003) 1472-1478
    • (2003) Epilepsia , vol.44 , pp. 1472-1478
    • Stables, J.P.1    Bertram, E.2    Dudek, F.E.3    Holmes, G.4    Mathern, G.5    Pitkanen, A.6
  • 4
    • 0042416551 scopus 로고    scopus 로고
    • Preclinical development of antiepileptic drugs: past, present, and future directions
    • White H.S. Preclinical development of antiepileptic drugs: past, present, and future directions. Epilepsia 44 Suppl. 7 (2003) 2-8
    • (2003) Epilepsia , vol.44 , Issue.SUPPL. 7 , pp. 2-8
    • White, H.S.1
  • 5
    • 0021996795 scopus 로고
    • Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate
    • Piredda S.G., Woodhead J.H., and Swinyard E.A. Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate. J Pharmacol Exp Ther 232 (1985) 741-745
    • (1985) J Pharmacol Exp Ther , vol.232 , pp. 741-745
    • Piredda, S.G.1    Woodhead, J.H.2    Swinyard, E.A.3
  • 6
    • 0010506065 scopus 로고
    • Comparison of maximal seizures evoked by pentylenetetrazol (metrazol) and electroshock in mice and their modification by anticonvulsants
    • Goodman L.S., Grewal M.S., Brown W.C., and Swinyard E.A. Comparison of maximal seizures evoked by pentylenetetrazol (metrazol) and electroshock in mice and their modification by anticonvulsants. J Pharmacol Exp Ther 108 (1953) 168-176
    • (1953) J Pharmacol Exp Ther , vol.108 , pp. 168-176
    • Goodman, L.S.1    Grewal, M.S.2    Brown, W.C.3    Swinyard, E.A.4
  • 7
    • 0026490745 scopus 로고
    • Pharmacological models of generalized absence seizures in rodents
    • Snead O.C. Pharmacological models of generalized absence seizures in rodents. J Neural Transm Suppl 35 (1992) 7-19
    • (1992) J Neural Transm Suppl , vol.35 , pp. 7-19
    • Snead, O.C.1
  • 8
    • 0002544304 scopus 로고
    • Experimental selection, quantification and evaluation of anticonvulsants
    • Levy R., Mattson R., Meldrum B., Penry J.K., and Dreifuss F.E. (Eds), Raven Press, New York
    • Swinyard E.A., Woodhead J.H., White H.S., and Franklin M.R. Experimental selection, quantification and evaluation of anticonvulsants. In: Levy R., Mattson R., Meldrum B., Penry J.K., and Dreifuss F.E. (Eds). Antiepileptic drugs. 3rd ed. (1989), Raven Press, New York 85-102
    • (1989) Antiepileptic drugs. 3rd ed. , pp. 85-102
    • Swinyard, E.A.1    Woodhead, J.H.2    White, H.S.3    Franklin, M.R.4
  • 9
    • 0029015820 scopus 로고
    • The early identification of anticonvulsant activity: role of the maximal electroshock and subcutaneous pentylenetetrazol seizure models
    • White H.S., Johnson M., Wolf H.H., and Kupferberg H.J. The early identification of anticonvulsant activity: role of the maximal electroshock and subcutaneous pentylenetetrazol seizure models. Ital J Neurol Sci 16 (1995) 73-77
    • (1995) Ital J Neurol Sci , vol.16 , pp. 73-77
    • White, H.S.1    Johnson, M.2    Wolf, H.H.3    Kupferberg, H.J.4
  • 10
    • 0030951771 scopus 로고    scopus 로고
    • Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs
    • White H.S. Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs. Epilepsia 38 Suppl. (1997) S9-S17
    • (1997) Epilepsia , vol.38 , Issue.SUPPL
    • White, H.S.1
  • 11
    • 84958122975 scopus 로고
    • Timed intravenous infusion of metrazol and strychnine for testing anticonvulsant drugs
    • Orloff M.J., Williams H.L., and Pfeiffer C.C. Timed intravenous infusion of metrazol and strychnine for testing anticonvulsant drugs. Proc Soc Exp Biol Med 70 (1949) 254-257
    • (1949) Proc Soc Exp Biol Med , vol.70 , pp. 254-257
    • Orloff, M.J.1    Williams, H.L.2    Pfeiffer, C.C.3
  • 12
    • 0022457277 scopus 로고
    • Optimizing the pentetrazol infusion test for seizure threshold measurement
    • Nutt D.J., Taylor S.C., and Little H.J. Optimizing the pentetrazol infusion test for seizure threshold measurement. J Pharm Pharmacol 38 (1986) 697-698
    • (1986) J Pharm Pharmacol , vol.38 , pp. 697-698
    • Nutt, D.J.1    Taylor, S.C.2    Little, H.J.3
  • 13
    • 0021906711 scopus 로고
    • A timed intravenous pentylenetetrazol infusion seizure model for quantitating the anticonvulsant effect of valproic acid in the rat
    • Pollack G.M., and Shen D.D. A timed intravenous pentylenetetrazol infusion seizure model for quantitating the anticonvulsant effect of valproic acid in the rat. J Pharmacol Methods 13 (1985) 135-146
    • (1985) J Pharmacol Methods , vol.13 , pp. 135-146
    • Pollack, G.M.1    Shen, D.D.2
  • 14
    • 0025817126 scopus 로고
    • The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazol seizure models
    • Loscher W., Honack D., Fassbender C.P., and Nolting B. The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazol seizure models. Epilepsy Res 8 (1991) 171-189
    • (1991) Epilepsy Res , vol.8 , pp. 171-189
    • Loscher, W.1    Honack, D.2    Fassbender, C.P.3    Nolting, B.4
  • 15
    • 0020692951 scopus 로고
    • The evaluation of different types of anti-convulsant drug activity against leptazol-induced epileptogenic activity in the anesthetized rat
    • Kent A.P., and Webster R.A. The evaluation of different types of anti-convulsant drug activity against leptazol-induced epileptogenic activity in the anesthetized rat. Br J Pharmacol 78 (1983) 553-559
    • (1983) Br J Pharmacol , vol.78 , pp. 553-559
    • Kent, A.P.1    Webster, R.A.2
  • 16
    • 0023897574 scopus 로고
    • Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations
    • Loscher W., and Schmidt D. Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res 2 (1988) 145-181
    • (1988) Epilepsy Res , vol.2 , pp. 145-181
    • Loscher, W.1    Schmidt, D.2
  • 17
    • 84940141832 scopus 로고
    • Comparative assays of antiepileptic drugs in mice and rats
    • Swinyard E.A., Brown W.C., and Goodman L.S. Comparative assays of antiepileptic drugs in mice and rats. J Pharmacol Exp Ther 106 (1952) 319-330
    • (1952) J Pharmacol Exp Ther , vol.106 , pp. 319-330
    • Swinyard, E.A.1    Brown, W.C.2    Goodman, L.S.3
  • 18
    • 0036345479 scopus 로고    scopus 로고
    • New strategies for the identification of drugs to prevent the development or progression of epilepsy
    • Schmidt D., and Rogawski M.A. New strategies for the identification of drugs to prevent the development or progression of epilepsy. Epilepsy Res 50 (2002) 71-78
    • (2002) Epilepsy Res , vol.50 , pp. 71-78
    • Schmidt, D.1    Rogawski, M.A.2
  • 19
    • 3242808732 scopus 로고    scopus 로고
    • Chemoconvulsants
    • Peterson S.L., and Albertson T.E. (Eds), CRC, Boca Raton
    • White H.S. Chemoconvulsants. In: Peterson S.L., and Albertson T.E. (Eds). Neuropharmacology methods in epilepsy research (1998), CRC, Boca Raton 24-40
    • (1998) Neuropharmacology methods in epilepsy research , pp. 24-40
    • White, H.S.1
  • 20
    • 0018852261 scopus 로고
    • Relationship between pentylenetetrazol-induced seizures and brain pentylenetetrazol levels in mice
    • Yonekawa W.D., Kupferberg H.J., and Woodbury D.M. Relationship between pentylenetetrazol-induced seizures and brain pentylenetetrazol levels in mice. J Pharmacol Exp Ther 214 (1980) 589-593
    • (1980) J Pharmacol Exp Ther , vol.214 , pp. 589-593
    • Yonekawa, W.D.1    Kupferberg, H.J.2    Woodbury, D.M.3
  • 21
    • 0021921241 scopus 로고
    • Kinetics of drug action in disease states. XIV. Effect of infusion rate on pentylenetetrazol concentrations in serum, brain and cerebrospinal fluid of rats at onset of convulsions
    • Ramzan I.M., and Levy G. Kinetics of drug action in disease states. XIV. Effect of infusion rate on pentylenetetrazol concentrations in serum, brain and cerebrospinal fluid of rats at onset of convulsions. J Pharmacol Exp Ther 234 (1985) 624-628
    • (1985) J Pharmacol Exp Ther , vol.234 , pp. 624-628
    • Ramzan, I.M.1    Levy, G.2
  • 22
    • 0021361095 scopus 로고
    • Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-GABA receptor-ionophore complex
    • Ramanjaneyulu R., and Ticku M.K. Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-GABA receptor-ionophore complex. Eur J Pharmacol 98 (1984) 337-345
    • (1984) Eur J Pharmacol , vol.98 , pp. 337-345
    • Ramanjaneyulu, R.1    Ticku, M.K.2
  • 24
    • 0032992977 scopus 로고    scopus 로고
    • A receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density
    • A receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density. J Pharmacol Exp Ther 289 (1999) 1626-1633
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 1626-1633
    • Walsh, L.A.1    Li, M.2    Zhao, T.J.3    Chiu, T.H.4    Rosenberg, H.C.5
  • 25
    • 0027223365 scopus 로고
    • Valproate and sodium currents in cultured hippocampal neurons
    • Van den Berg R.J., Kok P., and Voskuyl R.A. Valproate and sodium currents in cultured hippocampal neurons. Exp Brain Res 93 (1993) 279-287
    • (1993) Exp Brain Res , vol.93 , pp. 279-287
    • Van den Berg, R.J.1    Kok, P.2    Voskuyl, R.A.3
  • 26
    • 0025309183 scopus 로고
    • Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons
    • Kelly K.M., Gross R.A., and Macdonald R.L. Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons. Neurosci Lett 116 (1990) 233-238
    • (1990) Neurosci Lett , vol.116 , pp. 233-238
    • Kelly, K.M.1    Gross, R.A.2    Macdonald, R.L.3
  • 27
    • 0025050694 scopus 로고
    • Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds
    • Rogawski M.A., and Porter R.J. Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol Rev 42 (1990) 223-286
    • (1990) Pharmacol Rev , vol.42 , pp. 223-286
    • Rogawski, M.A.1    Porter, R.J.2
  • 29
    • 0035097209 scopus 로고    scopus 로고
    • Oxcarbazepine. An update of its efficacy in the management of epilepsy
    • Wellington K., and Goa K.L. Oxcarbazepine. An update of its efficacy in the management of epilepsy. CNS Drugs 15 (2001) 137-163
    • (2001) CNS Drugs , vol.15 , pp. 137-163
    • Wellington, K.1    Goa, K.L.2
  • 30
    • 0031957398 scopus 로고    scopus 로고
    • Advances in the medical treatment of epilepsy
    • Bazil C.W., and Pedley T.A. Advances in the medical treatment of epilepsy. Annu Rev Med 49 (1998) 135-162
    • (1998) Annu Rev Med , vol.49 , pp. 135-162
    • Bazil, C.W.1    Pedley, T.A.2
  • 31
    • 0031908063 scopus 로고    scopus 로고
    • Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy
    • Loscher W., Honack D., and Rundfeldt C. Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy. J Pharmacol Exp Ther 284 (1998) 474-479
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 474-479
    • Loscher, W.1    Honack, D.2    Rundfeldt, C.3
  • 33
    • 0030574062 scopus 로고    scopus 로고
    • The novel antiepileptic drug (ucb L059) induces alterations in GABA metabolism and turnover in discrete areas of rat brain and reduces neuronal activity in substantia nigra pars reticulata
    • Loscher W., Honack D., and Bloms-Funke P. The novel antiepileptic drug (ucb L059) induces alterations in GABA metabolism and turnover in discrete areas of rat brain and reduces neuronal activity in substantia nigra pars reticulata. Brain Res 735 (1996) 208-216
    • (1996) Brain Res , vol.735 , pp. 208-216
    • Loscher, W.1    Honack, D.2    Bloms-Funke, P.3
  • 35
    • 0025757288 scopus 로고
    • Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilepsy
    • Silver J.M., Shin C., and Mcnamara J.O. Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilepsy. Ann Neurol 29 (1991) 356-363
    • (1991) Ann Neurol , vol.29 , pp. 356-363
    • Silver, J.M.1    Shin, C.2    Mcnamara, J.O.3
  • 37
    • 0023266775 scopus 로고
    • Functional anatomy of pentylenetetrazol and electroshock seizures in the rat brain stem
    • Miller J.W., McKeon A.C., and Ferrendelli J.A. Functional anatomy of pentylenetetrazol and electroshock seizures in the rat brain stem. Ann Neurol 22 (1987) 615-621
    • (1987) Ann Neurol , vol.22 , pp. 615-621
    • Miller, J.W.1    McKeon, A.C.2    Ferrendelli, J.A.3
  • 38
    • 0038666152 scopus 로고    scopus 로고
    • Effect of topiramate on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy
    • Borowicz K.K., Luszczki J.J., Duda A.M., and Czuczwar S.J. Effect of topiramate on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy. Epilepsia 44 (2003) 640-646
    • (2003) Epilepsia , vol.44 , pp. 640-646
    • Borowicz, K.K.1    Luszczki, J.J.2    Duda, A.M.3    Czuczwar, S.J.4
  • 39
    • 0029975930 scopus 로고    scopus 로고
    • The novel anticonvulsant drug, gabapentin (neurontin), binds to the α2δ subunit of a calcium channel
    • Gee N.S., Brown J.P., Dissanayake V.U., Offord J., Thurlow R., and Woodruff G.N. The novel anticonvulsant drug, gabapentin (neurontin), binds to the α2δ subunit of a calcium channel. J Biol Chem 271 (1996) 5768-5776
    • (1996) J Biol Chem , vol.271 , pp. 5768-5776
    • Gee, N.S.1    Brown, J.P.2    Dissanayake, V.U.3    Offord, J.4    Thurlow, R.5    Woodruff, G.N.6
  • 40
    • 13444291643 scopus 로고    scopus 로고
    • Voltage gated ion channels: targets for anticonvulsant drugs
    • Errington A.C., Stohr T., and Lees G. Voltage gated ion channels: targets for anticonvulsant drugs. Curr Top Med Chem 5 (2005) 15-30
    • (2005) Curr Top Med Chem , vol.5 , pp. 15-30
    • Errington, A.C.1    Stohr, T.2    Lees, G.3


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