Design, synthesis and evaluation of dialkyl 4-(benzo[d][1,3]dioxol-6-yl)-1, 4-dihydro-2,6-dimethyl-1-substituted pyridine-3,5-dicarboxylates as potential anticonvulsants and their molecular properties prediction

European Journal of Medicinal Chemistry

Volumn 66, Issue , 2013, Pages 516-525

  Prasanthi, G ^a   Prasad, K V S R G ^a   Bharathi, K ^a  

^a INSTITUTE OF PHARMACEUTICAL TECHNOLOGY   (India)

Author keywords

1,4 Dihydropyridine; Anticonvulsant activity; Antinociceptive activity; Benzofurazanyl; Benzo d 1,3 dioxo 6 yl

Indexed keywords

3 ETHYL 5 METHYL 4 [BENZO(D)(1,3)DIOXOL 6 YL] 1,4 DIHYDRO 2,6 DIMETHYL 1 (2 NITROPHENYL) PYRIDINE 3,5 DICARBOXYLATE; 3 ETHYL 5 METHYL 4 [BENZO(D)(1,3)DIOXOL 6 YL] 1,4 DIHYDRO 2,6 DIMETHYL 1 (3 NITROPHENYL) PYRIDINE 3,5 DICARBOXYLATE; 3 ETHYL 5 METHYL 4 [BENZO(D)(1,3)DIOXOL 6 YL] 1,4 DIHYDRO 2,6 DIMETHYL 1 (4 NITROPHENYL) PYRIDINE 3,5 DICARBOXYLATE; 3 ETHYL 5 METHYL 4 [BENZO(D)(1,3)DIOXOL 6 YL] 1,4 DIHYDRO 2,6 DIMETHYL 1 PHENYL PYRIDINE 3,5 DICARBOXYLATE; 3 ETHYL 5 METHYL 4 [BENZO(D)(1,3)DIOXOL 6 YL] 1,4 DIHYDRO 2,6 DIMETHYL PYRIDINE 3,5 DICARBOXYLATE; ANTICONVULSIVE AGENT; ANTINOCICEPTIVE AGENT; ANTIOXIDANT; DIAZEPAM; DICARBOXYLIC ACID DERIVATIVE; DIETHYL 4 [BENZO(D)(1,3)DIOXOL 6 YL] 1,4 DIHYDRO 2,6 DIMETHYL 1 (2 NITROPHENYL) PYRIDINE 3,5 DICARBOXYLATE; DIETHYL 4 [BENZO(D)(1,3)DIOXOL 6 YL] 1,4 DIHYDRO 2,6 DIMETHYL 1 (3 NITROPHENYL) PYRIDINE 3,5 DICARBOXYLATE; DIETHYL 4 [BENZO(D)(1,3)DIOXOL 6 YL] 1,4 DIHYDRO 2,6 DIMETHYL 1 (4 NITROPHENYL) PYRIDINE 3,5 DICARBOXYLATE; DIETHYL 4 [BENZO(D)(1,3)DIOXOL 6 YL] 1,4 DIHYDRO 2,6 DIMETHYL 1 PHENYL PYRIDINE 3,5 DICARBOXYLATE; DIETHYL 4 [BENZO(D)(1,3)DIOXOL 6 YL] 1,4 DIHYDRO 2,6 DIMETHYL PYRIDINE 3,5 DICARBOXYLATE; DIMETHYL 4 [BENZO(D)(1,3)DIOXOL 6 YL] 1,4 DIHYDRO 2,6 DIMETHYL 1 (2 NITROPHENYL) PYRIDINE 3,5 DICARBOXYLATE; DIMETHYL 4 [BENZO(D)(1,3)DIOXOL 6 YL] 1,4 DIHYDRO 2,6 DIMETHYL 1 (3 NITROPHENYL) PYRIDINE 3,5 DICARBOXYLATE; DIMETHYL 4 [BENZO(D)(1,3)DIOXOL 6 YL] 1,4 DIHYDRO 2,6 DIMETHYL 1 (4 NITROPHENYL) PYRIDINE 3,5 DICARBOXYLATE; DIMETHYL 4 [BENZO(D)(1,3)DIOXOL 6 YL] 1,4 DIHYDRO 2,6 DIMETHYL 1 PHENYL PYRIDINE 3,5 DICARBOXYLATE; DIMETHYL 4 [BENZO(D)(1,3)DIOXOL 6 YL] 1,4 DIHYDRO 2,6 DIMETHYL PYRIDINE 3,5 DICARBOXYLATE; NIFEDIPINE; PHENYTOIN; UNCLASSIFIED DRUG; 3 ETHYL, 5 METHYL 4 (BENZO[D][1,3]DIOXOL 6 YL) 1,4 DIHYDRO 2, 6 DIMETHYL 1 PHENY PYRIDINE 3,5 DICARBOXYLATE; 3 ETHYL, 5 METHYL 4 (BENZO[D][1,3]DIOXOL 6 YL) 1,4 DIHYDRO 2, 6 DIMETHYLPYRIDINE 3,5 DICARBOXYLATE; 3 ETHYL, 5 METHYL 4 (BENZO[D][1,3]DIOXOL 6 YL) 1,4 DIHYDRO 2,6 DIMETHYL 1 (2 NITRO PHENYL)PYRIDINE 3,5 DICARBOXYLATE; 3 ETHYL, 5 METHYL 4 (BENZO[D][1,3]DIOXOL 6 YL) 1,4 DIHYDRO 2,6 DIMETHYL 1 (3 NITRO PHENYL)PYRIDINE 3,5 DICARBOXYLATE; 3 ETHYL, 5 METHYL 4 (BENZO[D][1,3]DIOXOL 6 YL) 1,4 DIHYDRO 2,6 DIMETHYL 1 (4 NITRO PHENYL)PYRIDINE 3,5 DICARBOXYLATE; CARBOXYLIC ACID DERIVATIVE; DIETHYL 4 (BENZO[D][1,3]DIOXOL 6 YL) 1,4 DIHYDRO 2,6 DIMETHYL 1 (2 NITROPHENYL)PYRIDINE 3,5 DICARBOXYLATE; DIETHYL 4 (BENZO[D][1,3]DIOXOL 6 YL) 1,4 DIHYDRO 2,6 DIMETHYL 1 (3 NITROPHENYL)PYRIDINE 3,5 DICARBOXYLATE; DIETHYL 4 (BENZO[D][1,3]DIOXOL 6 YL) 1,4 DIHYDRO 2,6 DIMETHYL 1 (4 NITROPHENYL)PYRIDINE 3,5 DICARBOXYLATE; DIETHYL 4 (BENZO[D][1,3]DIOXOL 6 YL) 1,4 DIHYDRO 2,6 DIMETHYL PYRIDINE 3,5 DICARBOXYLATE; DIMETHYL 4 (BENZO[D][1,3]DIOXOL 6 YL) 1,4 DIHYDRO 2,6 DIMETHYL 1 (2 NITROPHENYL)PYRIDINE 3,5 DICARBOXYLATE; DIMETHYL 4 (BENZO[D][1,3]DIOXOL 6 YL) 1,4 DIHYDRO 2,6 DIMETHYL 1 (3 NITROPHENYL)PYRIDINE 3,5 DICARBOXYLATE; DIMETHYL 4 (BENZO[D][1,3]DIOXOL 6 YL) 1,4 DIHYDRO 2,6 DIMETHYL 1 (4 NITROPHENYL)PYRIDINE 3,5 DICARBOXYLATE; DIMETHYL 4 (BENZO[D][1,3]DIOXOL 6 YL) 1,4 DIHYDRO 2,6 DIMETHYL 1 PHENYL PYRIDINE 3,5 DICARBOXYLATE; DIMETHYL 4 (BENZO[D][1,3]DIOXOL 6 YL) 1,4 DIHYDRO 2,6 DIMETHYL PYRIDINE 3,5 DICARBOXYLATE; ISRADIPINE; PENTETRAZOLE; PROTECTIVE AGENT; PYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ANTINOCICEPTION; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ELECTRIC SHOCK; IC 50; MALE; NONHUMAN; RAT; ANIMAL CELL; ANIMAL TISSUE; ASSESSMENT OF HUMANS; COMPARATIVE STUDY; DPPH RADICAL SCAVENGING ASSAY; IC50; IN VITRO STUDY; IN VIVO STUDY; MAXIMAL ELECTRIC SHOCK TEST; MOUSE; NEUROPROTECTION; PENTYLENETETRAZOLE-INDUCED SEIZURE; PLASMA PROTEIN BINDING; PREDICTION; PROTON NUCLEAR MAGNETIC RESONANCE; SEIZURE; SUBCUTANEOUS PENTYLENETETRAZOLE SEIZURE TEST;

EID: 84879817537     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.06.006     Document Type: Article

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