Metabolism of lamotrigine to a reactive arene oxide intermediate

Chemical Research in Toxicology

Volumn 13, Issue 11, 2000, Pages 1075-1081

  Maggs, J L ^a   Naisbitt, D J ^a   Tettey, J N A ^a   Pirmohamed, M ^a   Park, B K ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; EPOXIDE; GLUTATHIONE; KETOCONAZOLE; LAMOTRIGINE; OXIDE; POLYCYCLIC AROMATIC HYDROCARBON; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SULFIDE;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG ACTIVATION; DRUG GLUCURONIDATION; DRUG METABOLISM; HUMAN; HYPERSENSITIVITY REACTION; LIVER MICROSOME; MALE; NONHUMAN; RAT; RISK ASSESSMENT;

ANIMALS; ANTICONVULSANTS; BILE; BIOTRANSFORMATION; CARBON RADIOISOTOPES; EPOXY COMPOUNDS; HEPATOCYTES; KIDNEY; LIVER; LUNG; MALE; MICROSOMES, LIVER; RATS; RATS, WISTAR; TISSUE DISTRIBUTION; TRIAZINES;

ANIMALIA; ARENE; RATTUS NORVEGICUS;

EID: 0033725544     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0000825     Document Type: Article

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