Synthesis and anticonvulsant activity of new phenytoin derivatives

European Journal of Medicinal Chemistry

Volumn 60, Issue , 2013, Pages 57-63

  Botros, S ^a   Khalil, Nadia A ^a   Naguib, Bassem H ^a   El Dash, Yara ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Anticonvulsant activity; Oxadiazole; Phenytoin; Thiadiazole; Triazole

Indexed keywords

1 [2 (2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL)ACETYL] 4 (4 CHLOROPHENYL) THIOSEMICARBAZIDE; 1 [2 (2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL)ACETYL] 4 (4 METHOXYPHENYL) THIOSEMICARBAZIDE; 1 [2 (2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL)ACETYL] 4 (4 METHYLPHENYL) THIOSEMICARBAZIDE; 1 [2 (2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL)ACETYL] 4 ETHYLTHIOSEMICARBAZIDE; 1 [2 (2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL)ACETYL] 4 PHENYLTHIOSEMICARBAZIDE; 3 [(4 ETHYL 5 SULPHANYL 4H 1,2,4 TRIAZOL 3 YL)METHYL] 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE; 3 [(4 PHENYL 5 SULPHANYL 4H 1,2,4 TRIAZOL 3 YL)METHYL] 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE; 3 [(5 ETHYLAMINO 1,3,4 THIADIAZOL 2 YL)METHYL] 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE; 3 [(5 PHENYLAMINO 1,3,4 THIADIAZOL 2 YL)METHYL] 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE; 3 [(5 SULPHANYL 1,3,4 OXADIAZOL 2 YL)METHYL] 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DION; 3 [[4 (4 CHLOROPHENYL) 5 SULPHANYL 4H 1,2,4 TRIAZOL 3 YL] METHYL] 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE; 3 [[4 (4 METHOXYPHENYL) 5 SULPHANYL 4H 1,2,4 TRIAZOL 3 YL] METHYL] 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE; 3 [[4 (4 METHYLPHENYL) 5 SULPHANYL 4H 1,2,4 TRIAZOL 3 YL] METHYL] 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE; 3 [[5 (4 METHOXYPHENYLAMINO) 1,3,4 THIADIAZOL 2 YL] METHYL] 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE; 3 [[5 (4 METHYLPHENYLAMINO) 1,3,4 THIADIAZOL 2 YL]METHYL] 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE; ANTICONVULSIVE AGENT; PENTETRAZOLE; PHENYTOIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC SHOCK; EPILEPSY; MOUSE; NEUROTOXICITY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; ROTAROD TEST;

ANIMALS; ANTICONVULSANTS; ELECTROSHOCK; MICE; MOLECULAR STRUCTURE; MOTOR ACTIVITY; PHENYTOIN; ROTAROD PERFORMANCE TEST; SEIZURES;

EID: 84871709945     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.11.025     Document Type: Article

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