A long QT mutation substitutes cholesterol for phosphatidylinositol-4,5- bisphosphate in KCNQ1 channel regulation

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Coyan, Fabien C ^a,b,c   Abderemane Ali, Fayal ^a,b,c   Amarouch, Mohamed Yassine ^a,b,c,f   Piron, Julien ^a,b,c   Mordel, Jérôme ^a,b,c   Nicolas, Céline S ^a,b,c   Steenman, Marja ^a,b   Mérot, Jean ^a,b,c   Marionneau, Céline ^a,b,c   Thomas, Annick ^d   Brasseur, Robert ^e   Baró, Isabelle ^a,b,c   Loussouarn, Gildas ^a,b,c  

^a L INSTITUT DU THORAX   (France)

^b CNRS   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^e UNIVERSITY OF LIÈGE   (Belgium)

^f UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNQ1; R243H; R539W; R555C; UNCLASSIFIED DRUG; MAGNESIUM;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CONTROLLED STUDY; COS 7 CELL LINE; NONHUMAN; PATCH CLAMP TECHNIQUE; PROTEIN LIPID INTERACTION; QT PROLONGATION; ANIMAL; CELL LINE; CHLOROCEBUS AETHIOPS; CONGENITAL MALFORMATION; COS 1 CELL LINE; GENETICS; HEART ARRHYTHMIA; HEART MUSCLE CONDUCTION SYSTEM; LONG QT SYNDROME; METABOLISM; MUTATION;

ANIMALS; ARRHYTHMIAS, CARDIAC; CELL LINE; CERCOPITHECUS AETHIOPS; CHOLESTEROL; COS CELLS; HEART CONDUCTION SYSTEM; KCNQ1 POTASSIUM CHANNEL; LONG QT SYNDROME; MAGNESIUM; MUTATION; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE;

EID: 84899821150     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0093255     Document Type: Article

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