Probucol and the cholesterol synthesis inhibitors simvastatin and triparanol regulate Iks channel function differently

Human and Experimental Toxicology

Volumn 32, Issue 10, 2013, Pages 1028-1037

  Hihara, Taro ^a,b   Taniguchi, Tomohiko ^b   Ueda, Masataka ^b   Yoshinaga, Takashi ^b   Miyamoto, Norimasa ^a,b   Sawada, Kohei ^a,b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b EISAI CO LTD   (Japan)

Author keywords

KCNE1; KCNQ1; probucol; QT prolongation; simvastatin; triparanol

Indexed keywords

DELAYED RECTIFIER POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNQ1; PROBUCOL; SIMVASTATIN; TRIPARANOL;

ARTICLE; CHOLESTEROL SYNTHESIS; DRUG EFFECT; DRUG MECHANISM; ELECTROPHYSIOLOGY; MAXIMUM PLASMA CONCENTRATION; PATCH CLAMP; PRIORITY JOURNAL; QT PROLONGATION; REGULATORY MECHANISM;

KCNE1; KCNQ1; PROBUCOL; QT PROLONGATION; SIMVASTATIN; TRIPARANOL;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CHO CELLS; CHOLESTEROL; CRICETULUS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROBUCOL; SIMVASTATIN; TRIPARANOL;

EID: 84886399568     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327112474848     Document Type: Article

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