Signal transduction during cardiac hypertrophy: The role of Gα(q), PLC βI, and PKC

Cardiovascular Research

Volumn 44, Issue 1, 1999, Pages 5-9

  Jalili, Thunder ^b   Takeishi, Yasuchika ^a   Walsh, Richard A ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; CALCIUM CHANNEL; ENDOTHELIN; GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATE; ION CHANNEL; PHENYLEPHRINE; PHOSPHOLIPASE C; PROTEIN KINASE C; RYANODINE RECEPTOR; TRANSCRIPTION FACTOR;

ENZYME ACTIVATION; GUINEA PIG; HEART FAILURE; HEART VENTRICLE HYPERTROPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

CARDIOMEGALY; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEINS; HUMANS; ISOENZYMES; MYOCARDIUM; PHOSPHOLIPASE C; PROTEIN KINASE C; SIGNAL TRANSDUCTION;

EID: 0002565735     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(99)00211-4     Document Type: Review

References (35)

1. Zafeiridis A., Jeevanandam V., Houser S.R., Margulies K.B. Regression of cellular hypertrophy after left ventricular assist device support. Circulation. 98:1998;656-662.
2. Sakata Y., Hoit B.D., Liggett S.B., Walsh R.A., Dorn G.W. Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice. Circulation. 97:1998;1488-1495.
3. Meij J.T. Regulation of G protein function: implications for heart disease. Mol Cell Biochem. 157:1996;31-38.
4. Schnabel P., Gas H., Nohr T., Camps M., Bohm M. Identification and characterization of G protein-regulated phospholipase C in human myocardium. J Mol Cell Cardiol. 28:1996;2419-2427.
5. Berman D.M., Gilman A.G. Mammalian RGS proteins: barbarians at the gate. J Biol Chem. 273:1998;1269-1272.
6. Neer E.J. Heterotrimeric G proteins: organizers of transmembrane signals. Cell. 80:1995;249-257.
7. Sadoshima J., Izumo S. Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. EMBO J. 12:1993;1681-1992.
8. Kojima M., Shiojima I., Yamazaki T., et al. Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitro. Circulation. 89:1994;2204-2211.
9. Yamazaki T., Komuro I., Shiojima I., Yazaki Y. Angiotensin II mediates mechanical stress-induced cardiac hypertrophy. Diabetes Res Clin Pract. 3:(Suppl):1996;107-111.
10. D'Angelo D.D., Sakata Y., Lorenz J.N., Boivin G.P., Walsh R., Dorn G. Transgenic Gαq overexpression induces cardiac contractile failure in mice. Proc Natl Acad Sci USA. 94:1997;8121-8126.
11. Akhter S.A., Luttrell L.M., Rockman H.A., et al. Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science. 280:1998;574-577.
12. Harada K., Komuro I., Shiojima I., et al. Pressure overload induces cardiac hypertrophy in angiotensin II type 1A receptor knockout mice. Circulation. 97:1998;1952-1959.
13. Hamawaki M., Coffman T.M., Lashus A., et al. Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors. Am J Physiol. 274:1998;H868-H873.
14. LaBelle E.F., Polyak F. Phospholipase C β 2 in vascular smooth muscle. J Cell Physiol. 169:1996;358-363.
15. Lee C.W., Lee K.H., Lee S.B., Park D., Rhee S.G. Regulation of phospholipase C-β 4 by ribonucleotides and the alpha subunit of Gq. J Biol Chem. 269:1994;25335-25338.
16. Roustan P., Abitbol M., Menini C., et al. The rat phospholipase C β 4 gene is expressed at high abundance in cerebellar Purkinje cells. NeuroReport. 6:1995;1837-1841.
17. Berstein G., Blank J.L., Jhon D.Y., et al. Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator. Cell. 70:1992;411-418.
18. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science. 258:1992;607-614.
19. Brodde O.E., Michel M.C., Zerkowski H.R. Signal transduction mechanisms controlling cardiac contractility and their alterations in chronic heart failure. Cardiovasc Res. 30:1995;570-584.
20. Dekker L.V., Parker P.J. Protein kinase C - a question of specificity. Trends Biochem Sci. 19:1994;73-77.
21. Newton A.C. Regulation of protein kinase C. Curr Opin Cell Biol. 9:1997;161-167.
22. Shubeita H.E., Martinson E.A., Van Bilsen M., Chien K.R., Brown J.H. Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes. Proc Natl Acad Sci USA. 89:1992;1305-1309.
23. Chien K.R., Knowlton K.U., Zhu H., Chien S. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response. FASEB J. 5:1991;3037-3046.
24. Zamponi G.W., Bourinet E., Nelson D., Nargeot J., Snutch T.P. Crosstalk between G proteins and protein kinase C mediated by the calcium channel alpha1 subunit. Nature. 385:1997;442-446.
25. Sugden P.H., Bogoyevitch M.A. Intracellular signalling through protein kinases in the heart. Cardiovasc Res. 30:1995;478-492.
26. Iwasa Y., Hosey M.M. Phosphorylation of cardiac sarcolemma proteins by the calcium-activated phospholipid-dependent protein kinase. J Biol Chem. 259:1984;534-540.
27. Takeishi Y., Chu G., Kirkpatrick D.M., et al. In vivo phosphorylation of cardiac troponin I by PKCβ2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts. J Clin Invest. 102:1998;72-78.
28. Jideama N.M., Noland T.A. Jr., Raynor R.L., et al. Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. J Biol Chem. 271:1996;23277-23283.
29. Disatnik M.H., Buraggi G., Mochly-Rosen D. Localization of protein kinase C isozymes in cardiac myocytes. Exp Cell Res. 210:1994;287-297.
30. Bogoyevitch M.A., Glennon P.E., Sugden P.H. Endothelin-1, phorbol esters and phenylephrine stimulate MAP kinase activities in ventricular cardiomyocytes. FEBS Lett. 317:1993;271-275.
31. Gu X., Bishop S.P. Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat. Circ Res. 75:1994;926-931.
32. Paul K., Ball N.A., Dorn G.W., Walsh R.A. Left ventricular stretch stimulates angiotensin II-mediated phosphatidylinositol hydrolysis and protein kinase Cε isoform translocation in adult guinea pig hearts. Circ Res. 81:1997;643-650.
33. Takeishi Y., Bhagwat A., Ball N.A., et al. Effect of angiotensin converting enzyme inhibition on protein kinase C and SR proteins in heart failure. Am J Physiol. 276:1999;H53-H62.
34. Wakasaki H., Koya D., Schoen F.J., et al. Targeted overexpression of protein kinase C β2 isoform in myocardium causes cardiomyopathy. Proc Natl Acad Sci USA. 94:1997;9320-9325.
35. 2+ sensitive isoforms in the failing human heart. Circulation. 99:1999;384-391.