PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4–S5 linker

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 36, 2012, Pages E2399-E2408

  Rodriguez Menchaca, Aldo A ^a,b   Adney, Scott K ^a   Tang, Qiong Yao ^a   Meng, Xuan Yu ^a   Rosenhouse Dantsker, Avia ^a,c   Cui, Meng ^a   Logothetis, Diomedes E ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSIDAD AUTÓNOMA DE SAN LUIS POTOSÍ   (Mexico)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Channel modulation; Lipids; Open probability; Voltage gated channels

Indexed keywords

PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; VOLTAGE GATED POTASSIUM CHANNEL; PHOSPHOLIPID;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; ION CONDUCTANCE; LIPID MEMBRANE; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; SENSOR; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; KINETICS; MEMBRANE POTENTIAL; METABOLISM; MOLECULAR DYNAMICS; MUTAGENESIS; OOCYTE; PATCH CLAMP; PHYSIOLOGY; PROTEIN SUBUNIT; X RAY CRYSTALLOGRAPHY; XENOPUS;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS; OOCYTES; PATCH-CLAMP TECHNIQUES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHOLIPIDS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN SUBUNITS; XENOPUS;

EID: 84866336468     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1207901109     Document Type: Article

References (37)

1. + channels: II. The components of gating currents and a model of channel activation. Biophys J 66:1011–1021.
2. Zagotta WN, Hoshi T, Dittman J, Aldrich RW (1994) Shaker potassium channel gating. II: Transitions in the activation pathway. J Gen Physiol 103:279–319.
3. Smith-Maxwell CJ, Ledwell JL, Aldrich RW (1998) Role of the S4 in cooperativity of voltage-dependent potassium channel activation. J Gen Physiol 111:399–420.
4. Ledwell JL, Aldrich RW (1999) Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation. J Gen Physiol 113:389–414.
5. Stühmer W, et al. (1989) Structural parts involved in activation and inactivation of the sodium channel. Nature 339:597–603.
6. + channel. Nature 353:752–756.
7. + channel result in corresponding decreases in gating charge. Neuron 8:531–540.
8. + channel in a lipid membrane-like environment. Nature 450:376–382.
9. + channel. Nature 423:33–41.
10. Milescu M, et al. (2009) Interactions between lipids and voltage sensor paddles detected with tarantula toxins. Nat Struct Mol Biol 16:1080–1085.
11. Ramu Y, Xu Y, Lu Z (2006) Enzymatic activation of voltage-gated potassium channels. Nature 442:696–699.
12. + channels. Nature 451:826–829.
13. 2 with ion channels and transporters. Sci STKE 2001:re19.
14. Logothetis DE, Petrou VI, Adney SK, Mahajan R (2010) Channelopathies linked to plasma membrane phosphoinositides. Pflugers Arch 460:321–341.
15. + channels by membrane lipids. Science 304:265–270.
16. Murata Y, Iwasaki H, Sasaki M, Inaba K, Okamura Y (2005) Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature 435:1239–1243.
17. Kohout SC, et al. (2010) Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Nat Chem Biol 6:369–375.
18. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391:85–100.
19. 2 and its stabilization by Gbetagamma. Nature 391:803–806.
20. 2 interactions. Nat Cell Biol 1:183–188.
21. Zhang H, et al. (2003) PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents. Neuron 37:963–975.
22. Rosenhouse-Dantsker A, Logothetis DE (2007) Molecular characteristics of phosphoinositide binding. Pflugers Arch 455:45–53.
23. + channel. Science 309:897–903.
24. +) channel. Neuron 56:124–140.
25. Khalili-Araghi F, et al. (2010) Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel. Biophys J 98:2189–2198.
26. + channel Kir2.2. Nature 477:495–498.
27. Suh BC, Hille B (2005) Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate. Curr Opin Neurobiol 15:370–378.
28. 2 interactions underlie channelopathies. Neuron 34:933–944.
29. Loussouarn G, et al. (2003) Phosphatidylinositol-4,5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: A functional homology between voltage-gated and inward rectifier K+ channels. EMBO J 22:5412–5421.
30. Villalba-Galea CA, Sandtner W, Starace DM, Bezanilla F (2008) S4-based voltage sensors have three major conformations. Proc Natl Acad Sci USA 105:17600–17607.
31. Börjesson SI, Hammarström S, Elinder F (2008) Lipoelectric modification of ion channel voltage gating by polyunsaturated fatty acids. Biophys J 95:2242–2253.
32. 2. Nature 419:947–952.
33. Kahraman A, Morris RJ, Laskowski RA, Thornton JM (2007) Shape variation in protein binding pockets and their ligands. J Mol Biol 368:283–301.
34. Morris AL, MacArthur MW, Hutchinson EG, Thornton JM (1992) Stereochemical quality of protein structure coordinates. Proteins 12:345–364.
35. Morris GM, et al. (1998) Automated docking using a lamarckian genetic algorithm and an empirical binding free energy function. J Comput Chem 19:1639–1662.
36. Hess B, Kutzner C, van der Spoel D, Lindahl E (2008) GROMACS 4: Algorithms for highly efficient, load-balanced, and scalable molecular simulation. J Chem Theory Comput 4:435–447.
37. Oostenbrink C, van Gunsteren WF (2004) Free energies of binding of polychlorinated biphenyls to the estrogen receptor from a single simulation. Proteins 54:237–246.