Synthesis and cytotoxic activity of novel 3-(1H-indol-3-yl)-1H-pyrazole-5- carbohydrazide derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 12, 2011, Pages 5868-5877

  Zhang, Datong ^a   Wang, Guangtian ^a   Zhao, Guilong ^b   Xu, Weiren ^b   Huo, Lingyan ^a  

^a Shandong Polytechnic University   (China)

^b TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

Carbohydrazide; Cell cycle; Cytotoxic activity; Indole; Pyrazole; Synthesis

Indexed keywords

1 (2,4 DICHLOROBENZYL) 3 (1 PROPYL 1H INDOL 3 YL) 1H PYRAZOLE 5 CARBOHYDRAZIDE; 1 (3,4 DICHLOROBENZYL) 3 (1 PROPYL 1H INDOL 3 YL) 1H PYRAZOLE 5 CARBOHYDRAZIDE; 1 (3,4 DIMETHOXYBENZYL) 3 (1 PROPYL 1H INDOL 3 YL) 1H PYRAZOLE 5 CARBOHYDRAZIDE; 1 (4 FLUOROBENZYL) 3 (1 PROPYL 1H INDOL 3 YL) 1H PYRAZOLE 5 CARBOHYDRAZIDE; 1 (4 FLUOROBENZYL) 3 (1H INDOL 3 YL) 1H PYRAZOLE 5 CARBOHYDRAZIDE; 1 (4 FLUOROBENZYL) 5 (1 PROPYL 1H INDOL 3 YL) 1H PYRAZOLE 3 CARBOHYDRAZIDE; 1 (4 METHOXYBENZYL) 3 (1 PROPYL 1H INDOL 3 YL) 1H PYRAZOLE 5 CARBOHYDRAZIDE; 1 BENZYL 3 (1 PROPYL 1H INDOL 3 YL) 1H PYRAZOLE 5 CARBOHYDRAZIDE; 1 PROPYL 3 (1 PROPYL 1H INDOL 3 YL) 1H PYRAZOLE 5 CARBOHYDRAZIDE; 3 (1 BENZYL 1H INDOL 3 YL) 1 PROPYL 1H PYRAZOLE 5 CARBOHYDRAZIDE; 3 (1 PPROPYL 1H INDOL 3 YL) 1H PYRAZOLE 5 CARBOHYDRAZIDE; 3 [1 (2,4 DICHLOROBENZYL) 1H INDOL 3 YL] 1 PROPYL 1H PYRAZOLE 5 CARBOHYDRAZIDE; 3 [1 (3,4 DICHLOROBENZYL) 1H INDOL 3 YL] 1 PROPYL 1H PYRAZOLE 5 CARBOHYDRAZIDE; 3 [1 (3,4 DIMETHOXYBENZYL) 1H INDOL 3 YL] 1 PROPYL 1H PYRAZOLE 5 CARBOHYDRAZIDE; 3 [1 (4 FLUOROBENZYL) 1H INDOL 3 YL] 1 PROPYL 1H PYRAZOLE 5 CARBOHYDRAZIDE; 3 [1 (4 METHOXYBENZYL) 1H INDOL 3 YL] 1 PROPYL 1H PYRAZOLE 5 CARBOHYDRAZIDE; 5 [1 (4 FLUOROBENZYL) 1H INDOL 3 YL] 1 PROPYL 1H PYRAZOLE 3 CARBOHYDRAZIDE; ANTINEOPLASTIC AGENT; FLUOROURACIL; HYDRAZIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL ASSAY; CELL CYCLE ARREST; CELL CYCLE S PHASE; CHEMICAL REACTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDRAZINES; MODELS, MOLECULAR; NEOPLASMS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80955145694     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.09.049     Document Type: Article

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