Novel pyrazole derivatives: Synthesis and evaluation of anti-angiogenic activity

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 12, 2010, Pages 4338-4350

  Christodoulou, Michael S ^a   Liekens, Sandra ^b   Kasiotis, Konstantinos M ^a,c   Haroutounian, Serkos A ^a  

^a AGRICULTURAL UNIVERSITY OF ATHENS   (Greece)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c BENAKI PHYTOPATHOLOGICAL INSTITUTE   (Greece)

Author keywords

Angiogenesis; CAM assay; Endothelial cell proliferation and migration; Inhibition of tumor growth; Pyrazole; Pyrazolo 4,3 c quinoline

Indexed keywords

1 (4' HYDROXYPHENYL) 3 (3'' HYDROXYPHENYL) 1H PYRAZOLE 4 CARBOXALDEHYE; 1 (4' HYDROXYPHENYL) 3 (3'',4'' DIHYDROXYPHENYL) 1H PYRAZOLE 4 CARBOXALDEHYDE; 1 (4' HYDROXYPHENYL) 3 (4'' HYDROXYPHENYL) 1H PYRAZOLE 4 CARBOXALDEHYDE; 1 (4' HYDROXYPHENYL) 3 PHENYL 1H PYRAZOLE 4 CARBOXALDEHYDE; 4 [4 (1,4 BENZODIOXAN 6 YL) 5 METHYL 1H PYRAZOL 3 YL] 6 ETHYLRESORCINOL; 5 HYDROXY 2 (4' HYDROXYPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 4(5H) ONE; 5,7 DIHYDROXY 2 (4' HYDROXYPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 4(5H) ONE; 5,8 DIHYDROXY 2 (4' HYDROXYPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 4 ONE; ANGIOGENESIS INHIBITOR; PYRAZOLE DERIVATIVE; SEMAXANIB; UNCLASSIFIED DRUG; XRP 44X; CYTOSTATIC AGENT; QUINOLINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; BREAST CARCINOMA; CANCER INHIBITION; CARCINOMA CELL; CELL MIGRATION; CELL PROLIFERATION; CHICKEN; CHORIOALLANTOIS; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENDOTHELIUM CELL; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; ANIMAL; CELL MOTION; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; SYNTHESIS; TUMOR CELL LINE;

ANGIOGENESIS INHIBITORS; ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CHICKENS; CHORIOALLANTOIC MEMBRANE; CYTOSTATIC AGENTS; ENDOTHELIAL CELLS; HUMANS; MICE; PYRAZOLES; QUINOLINES;

EID: 77953127934     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.076     Document Type: Article

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