Synthesis, biological evaluation, and molecular docking studies of cinnamic acyl 1,3,4-thiadiazole amide derivatives as novel antitubulin agents

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 3, 2012, Pages 1181-1187

  Yang, Xian Hui ^a   Wen, Qing ^a   Zhao, Ting Ting ^a   Sun, Jian ^a   Li, Xi ^a   Xing, Man ^a   Lu, Xiang ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Antitubulin polymerization; Cinnamic acyl 1,3,4 thiadiazole amide derivatives; Molecular docking; Structure activity relationship

Indexed keywords

3 (4 FLUOROPHENYL) N (5 PHENYL 1,3,4 THIADIAZOL 2 YL)ACRYLAMIDE; 3 (4 FLUOROPHENYL) N [5 (4 METHOXYPHENYL) 1,3,4 THIADIAZOL 2 YL]ACRYLAMIDE; 3 (4 FLUOROPHENYL) N [5 (4 TOLYL) 1,3,4 THIADIAZOL 2 YL]ACRYLAMIDE; 3 (4 METHOXYPHENYL) N (5 PHENYL 1,3,4 THIADIAZOL 2 YL)ACRYLAMIDE; 3 (4 METHOXYPHENYL) N [5 (4 METHOXYPHENYL) 1,3,4 THIADIAZOL 2 YL]ACRYLAMIDE; 3 (4 METHOXYPHENYL) N [5 (4 TOLYL) 1,3,4 THIADIAZOL 2 YL]ACRYLAMIDE; 3 (4 TOLYL) N [5 (4 TOLYL) 1,3,4 THIADIAZOL 2 YL]ACRYLAMIDE; CINNAMIC ACID DERIVATIVE; CINNAMIC ACYL 1,3,4 THIADAZOLE AMIDE DERIVATIVE; COLCHICINE; N (5 PHENYL 1,3,4 THIADIAZOL 2 YL) 3 (PTOLYL)ACRYLAMIDE; N (5 PHENYL 1,3,4 THIADIAZOL 2 YL) 3 [4 (TRIFLUOROMETHYL)PHENYL]ACRYLAMIDE; N (5 PHENYL 1,3,4 THIADIAZOL 2 YL)CINNAMAMIDE; N [5 (4 BROMOPHENYL) 1,3,4 THIADIAZOL 2 YL] 3 (4 FLUOROPHENYL)ACRYLAMIDE; N [5 (4 BROMOPHENYL) 1,3,4 THIADIAZOL 2 YL] 3 (4 METHOXYPHENYL)ACRYLAMIDE; N [5 (4 BROMOPHENYL) 1,3,4 THIADIAZOL 2 YL] 3 (PTOLYL)ACRYLAMIDE; N [5 (4 BROMOPHENYL) 1,3,4 THIADIAZOL 2 YL] 3 [4 (TRIFLUOROMETHYL)PHENYL]ACRYLAMIDE; N [5 (4 BROMOPHENYL) 1,3,4 THIADIAZOL 2 YL]CINNAMAMIDE; N [5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL] 3 (4 FLUOROPHENYL)ACRYLAMIDE; N [5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL] 3 (4 METHOXYPHENYL)ACRYLAMIDE; N [5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL] 3 (PTOLYL)ACRYLAMIDE; N [5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL] 3 [4( TRIFLUOROMETHYL)PHENYL]ACRYLAMIDE; N [5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL]CINNAMIDE; N [5 (4 METHOXYPHENYL) 1,3,4 THIADIAZOL 2 YL]CINNAMAMIDE; N [5 (4 TOLYL) 1,3,4 THIADIAZOL 2 YL] 3 [4 (TRIFLUOROMETHYL)PHENYL]ACRYLAMIDE; N [5 (4 TOLYL) 1,3,4 THIADIAZOL 2 YL]CINNAMIDE; PROTEIN ANTIBODY; THIADIAZOLE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; PROTEIN POLYMERIZATION;

AMIDES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CINNAMATES; HUMANS; NEOPLASMS; THIADIAZOLES; TUBULIN; TUBULIN MODULATORS;

EID: 84862776639     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.12.057     Document Type: Article

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