Design and synthesis of new 1,3-benzthiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 15, 2009, Pages 5369-5373

  Zarghi, Afshin ^a   Zebardast, Tannaz ^a   Daraie, Bahram ^b   Hedayati, Mehdi ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TARBIAT MODARES UNIVERSITY   (Iran)

Author keywords

1,3 Benzthiazinan 4 ones; COX 2 inhibition; SAR

Indexed keywords

1,3 BENZTHIAZINAN 4 ONE DERIVATIVE; 3 (4 FLUOROPHENYL) 2 (4 METHYLSULFONYLPHENYL) 1,3 BENZTHIAZINAN 4 ONE; BENZTHIAZIDE; CELECOXIB; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; ROFECOXIB; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; INHIBITION KINETICS; NONHUMAN; PHARMACOPHORE;

ANIMALS; CATALYTIC DOMAIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DRUG DESIGN; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MURINAE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZINES;

EID: 67651091710     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.06.056     Document Type: Article

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