seco-Cyclothialidines: New concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties

Journal of Medicinal Chemistry

Volumn 44, Issue 4, 2001, Pages 619-626

  Rudolph, J ^a   Theis, H ^a   Hanke, R ^a   Endermann, R ^a   Johannsen, L ^a   Geschke, F U ^a  

^a BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOTHIAZOLE DERIVATIVE; ANTIINFECTIVE AGENT; BAY 50 7952; CYSTEINE DERIVATIVE; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); RO 61 6653; SECOCYCLOTHIALIDINE DERIVATIVE; TRITYL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GRAM POSITIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; RAT; REACTION ANALYSIS;

ANIMALS; ANTI-BACTERIAL AGENTS; COLONY COUNT, MICROBIAL; DNA TOPOISOMERASES, TYPE II; ENZYME INHIBITORS; FEMALE; GRAM-POSITIVE BACTERIA; HUMANS; HYDROXYBENZOIC ACIDS; MICE; STEREOISOMERISM; STREPTOCOCCAL INFECTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 0035865788     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0010623     Document Type: Article

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