2-(2-Hydrazinyl)thiazole derivatives: Design, synthesis and in vitro antimycobacterial studies

European Journal of Medicinal Chemistry

Volumn 69, Issue , 2013, Pages 564-576

  Makam, Parameshwar ^a   Kankanala, Ramakrishna ^a   Prakash, Amresh ^b   Kannan, Tharanikkarasu ^a  

^a PONDICHERRY UNIVERSITY   (India)

^b JAMIA MILLIA ISLAMIA CENTRAL UNIVERSITY   (India)

Author keywords

Ketoacyl ACP synthase; H37Rv Tuberculosis; Lipinski rule; Mycobacterium tuberculosis; Thiazole

Indexed keywords

1 [2 [2 (2H 1,3 BENZODIOXOL 4 YLMETHYLIDENE)HYDRAZIN 1 YL] 4 METHYL 1,3 THIAZOL 5 YL]ETHAN 1 ONE; 1 [2 [2 [(2,4 DICHLOROPHENYL)METHYLIDENE]HYDRAZIN 1 YL] 4 METHYL 1,3 THIAZOL 5 YL]ETHAN 1 ONE; 1 [4 METHYL 2 [2 [(3,4,5 TRIMETHOXYPHENYL)METHYLIDENE]HYDRAZIN 1 YL] 1,3 THIAZOL 5 YL]ETHAN 1 ONE; 2 (2 HYDRAZINYL)THIAZOLE DERIVATIVE; ANTIMYCOBACTERIAL AGENT; ETHYL 2 [2 (2H 1,3 BENZODIOXOL 4 YLMETHYLIDENE)HYDRAZIN 1 YL] 4 METHYL 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 2 [2 [(2 CHLOROPHENYL)METHYLIDENE]HYDRAZIN 1 YL] 4 METHYL 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 2 [2 [(2 HYDROXYPHENYL)METHYLIDENE]HYDRAZIN 1 YL] 4 METHYL 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 2 [2 [(2,4 DICHLOROPHENYL)METHYLIDENE]HYDRAZIN 1 YL] 4 METHYL 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 2 [2 [(3 BROMOPHENYL)METHYLIDENE]HYDRAZIN 1 YL] 4 METHYL 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 2 [2 [(3 ETHOXY 4 HYDROXYPHENYL)METHYLIDENE]HYDRAZIN 1 YL] 4 METHYL 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 2 [2 [(3 HYDROXY 4 METHOXYPHENYL)METHYLIDENE]HYDRAZIN 1 YL] 4 METHYL 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 2 [2 [(3 HYDROXYPHENYL)METHYLIDENE]HYDRAZIN 1 YL] 4 METHYL 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 2 [2 [(3,4 DIMETHOXYPHENYL)METHYLIDENE]HYDRAZIN 1 YL] 4 METHYL 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 2 [2 [(4 CHLOROPHENYL)METHYLIDENE]HYDRAZIN 1 YL] 4 METHYL 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 2 [2 [(4 HYDROXYPHENYL)METHYLIDENE]HYDRAZIN 1 YL] 4 METHYL 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 2 [2 [(4 METHOXYPHENYL)METHYLIDENE]HYDRAZIN 1 YL] 4 METHYL 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 2 [2 [1 (3 CHLOROPHENYL)ETHYLIDENE]HYDRAZIN 1 YL] 4 METHYL 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 2 [2 [1 (4 FLUOROPHENYL)ETHYLIDENE]HYDRAZIN 1 YL] 4 METHYL 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 2 [2 [[4 (DIMETHYLAMINO)PHENYL]METHYLIDENE]HYDRAZIN 1 YL] 4 METHYL 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 4 METHYL 2 [2 (1 PHENYLMETHYLIDENE)HYDRAZIN 1 YL] 1,3 THIAZOLE 5 CARBOXLATE; ETHYL 4 METHYL 2 [2 (PHENYLMETHYLIDENE)HYDRAZIN 1 YL] 1,3 THIAZOLE 5 CARBOXLATE; ETHYL 4 METHYL 2 [2 [(2 NITROPHENYL)METHYLIDENE]HYDRAZIN 1 YL] 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 4 METHYL 2 [2 [(3 NITROPHENYL)METHYLIDENE]HYDRAZIN 1 YL] 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 4 METHYL 2 [2 [(3,4,5 TRIMETHOXYPHENYL)METHYLIDENE]HYDRAZIN 1 YL] 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 4 METHYL 2 [2 [(4 METHYLPHENYL)METHYLIDENE]HYDRAZIN 1 YL] 1,3 THIAZOLE 5 CARBOXYLATE; ETHYL 4 METHYL 2 [2 [1 (PYRIDIN 2 YL)ETHYLIDENE]HYDRAZIN 1 YL] 1,3 THIAZOLE 5 CARBBOXYLATE; ETHYL 4 METHYL 2 [2 [[3 (PROPAN 2 YL)PHENYL]METHYLIDENE]HYDRAZIN 1 YL] 1,3 THIAZOLE 5 CARBOXYLATE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BACTERIUM CULTURE; CELL CULTURE; CELL GROWTH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; INCUBATION TIME; LUNG ALVEOLUS EPITHELIUM; LUNG CARCINOMA; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN;

AJLNXGLZYKBIHV-OVCLIPMQSA-N; ATCLBIWNPGMWSG-OVCLIPMQSA-N; AWQCONSMQKVQBL-GIJQJNRQSA-N; BCYRWBFBAGDLIB-OVCLIPMQSA-N; BLPWXDDAGXSZNF-OVCLIPMQSA-N; DDNNZKRMRHKNQS-LICLKQGHSA-N; DYBJAZJOMGWGMU-LZYBPNLTSA-N; GLONTBYWQCQJPI-CXUHLZMHSA-N; H(37)RV; HSJDULXAYHDAAN-LICLKQGHSA-N; HXVSXELBPPIAPZ-RQZCQDPDSA-N; IOEMKPCIYUVUTA-LICLKQGHSA-N; IQWRIXJIVQEGRB-FRKPEAEDSA-N; IULVWCSWFBMHJK-CAOOACKPSA-N; KOQVGOKQWDKPML-LICLKQGHSA-N; LIPINSKI RULE; LZGGZLIPZOLCIR-LZYBPNLTSA-N; MYCOBACTERIUM TUBERCULOSIS; NDMLDJHDLLJDGO-VCHYOVAHSA-N; NUOSUXUGASOFFG-CAOOACKPSA-N; NZQFXGZUKPADMY-OVCLIPMQSA-N; OEPJZLZXEYSGNE-RQZCQDPDSA-N; OXBYVSSRYGMHPL-RQZCQDPDSA-N; PCHGOUYNSVFNRU-GIJQJNRQSA-N; QBCSKDDXCWSUIG-OQLLNIDSSA-N; QUTYCERHMJSUCI-GIJQJNRQSA-N; REWRLGKLBXIIHM-RQZCQDPDSA-N; RWKFMSDAGJMQGY-REZTVBANSA-N; SHVRDDAHKAYCDP-CXUHLZMHSA-N; THIAZOLE; TUBERCULOSIS; TXEVAFMZVNPKTA-GIJQJNRQSA-N; UQRBVVWLXGAPDW-LZYBPNLTSA-N; VIVKMRRNLSXCDL-GIDUJCDVSA-N; VXHXOFMJZUBWBO-NTUHNPAUSA-N; WNVXUJRPBZSDLD-RQZCQDPDSA-N; YYDXDTMFUWSCQH-OVCLIPMQSA-N; ZEDHGYXLWKHHBR-OMCISZLKSA-N; ZKNJICDVJPXFAO-LZYBPNLTSA-N; ZXQUYAHQNLDHRY-LZYBPNLTSA-N; Β-KETOACYL-ACP SYNTHASE;

ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDRAZONES; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84884695627     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.08.054     Document Type: Article

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