Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B

Journal of Experimental Medicine

Volumn 211, Issue 5, 2014, Pages 769-779

  Carnevalli, Larissa S ^a,b   Scognamiglio, Roberta ^a,b   Cabezas Wallscheid, Nina ^b   Rahmig, Susann ^b   Laurenti, Elisa ^c   Masuda, Kohei ^d   Jöckel, Lars ^e   Sujer, Andrea Kuck ^b   Polykratis, Apostolos ^g   Erlacher, Miriam ^f   Pasparakis, Manolis ^g   Essers, Marieke A G ^a,b   Trumpp, Andreas ^a,b  

^a Hi STEM Heidelberg Institute for Stem Cell Technology and Experimental Medicine GmbH   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF TORONTO   (Canada)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^e UNIVERSITY OF FREIBURG   (Germany)

^f UNIVERSITY OF FREIBURG   (Germany)

^g UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; GRANZYME B; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL FUNCTION; CELL ISOLATION; CELL PROLIFERATION; CELL PROTECTION; CELLULAR STRESS RESPONSE; CHEMOTHERAPY; CONTROLLED STUDY; ENGRAFTMENT; FEMALE; HEMATOPOIETIC STEM CELL; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; APOPTOSIS; BONE MARROW; CELL PROLIFERATION; COLONY-FORMING UNITS ASSAY; DNA PRIMERS; DRUG THERAPY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUOROURACIL; GENE EXPRESSION REGULATION; GRANZYMES; HEMATOPOIETIC STEM CELLS; IMMUNOHISTOCHEMISTRY; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROARRAY ANALYSIS; MITOCHONDRIA; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL;

EID: 84899764827     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20131072     Document Type: Article

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