Roles of p53 and caspases in the induction of cell cycle arrest and apoptosis by HIV-1 vpr

Experimental Cell Research

Volumn 251, Issue 1, 1999, Pages 156-165

  Shostak, Laura D ^a   Ludlow, John ^a   Fisk, Jennifer ^a   Pursell, Shannon ^a   Rimel, Bobbie J ^a   Nguyen, Don ^a   Rosenblatt, Joseph D ^a   Planelles, Vicente ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE INHIBITOR; PROTEIN P53; VIRUS VECTOR; VPR PROTEIN;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL CYCLE; CELL CYCLE G2 PHASE; CELL PROLIFERATION; COLON CARCINOMA; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; LENTIVIRINAE; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0033603819     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1999.4568     Document Type: Article

References (57)

1. Adachi A., Gendelman H. E., Koenig S., Folks T., Willey R., Rabson A., Martin M. A. Production of acquired immunodeficiency syndrome-associated retrovirus in human and non-human cells transfected with an infectious molecular clone. J. Virol. 59:1986;284-291.
2. Adachi H., Adams A., Hughes F. M., Zhang J., Cidlowski J. A., Jetten A. M. Induction of apoptosis by the novel retinoid AHPN in human T-cell lymphoma cells involves caspase-dependent and independent pathways. Cell Death Differ. 5:1998;973-983.
3. Agarwal M. L., Agarwal A., Taylor W. R., Stark G. R. p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc. Natl. Acad. Sci. USA. 92:1995;8493-8497.
4. Aloni-Grinstein R., Schwartz D., Rotter V. Accumulation of wild-type p53 protein upon gamma-irradiation induces a G2 arrest-dependent immunoglobulin kappa light chain gene expression. Embo J. 14:1995;1392-1401.
5. Ameisen J. C., Capron A. Cell dysfunction and depletion in AIDS: The programmed cell death hypothesis. Immunol. Today. 12:1991;102-105.
6. Brown T. L., Patil S., Basnett R. K., Howe P. H. Caspase inhibitor BD-fmk distinguishes transforming growth factor beta-induced apoptosis from growth inhibition. Cell Growth Differ. 9:1998;869-875.
7. Bunz F., Dutriaux A., Lengauer C., Waldman T., Zhou S., Brown J. P., Sedivy J. M., Kinzler K. W., Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science. 282:1998;1497-1501.
8. Burns J. C., Friedmann T., Driever W., Burrascano M., Yee J. K. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. Proc. Natl. Acad. Sci. USA. 90:1993;8033-8037.
9. Chabner P. C. a. B. A. Antineoplastic Agents. Gilman G. A. The Pharmacological Basis of Therapeutics. 1993;8 McGraw-Hill, New York.
10. Chalfie M., Tu Y., Euskirchen G., Ward W. W., Prasher D. C. Green fluorescent protein as a marker for gene expression. Science. 263:1994;802-805.
11. Clarke A. R., Purdie C. A., Harrison D. J., Morris R. G., Bird C. C., Hooper M. L., Wyllie A. H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature. 362:1993;849-852.
12. Cohen E. A., Terwilliger E. F., Jalinoos Y., Proulx J., Sodroski J. G., Haseltine W. A. Identification of HIV-1 vpr product and function. J. Acquir. Immune Defic. Syndr. 3:1990;11-18.
13. Cohen G. M. Caspases: the executioners of apoptosis. Biochem. J. 326:1997;1-16.
14. Collins J. A., Schandi C. A., Young K. K., Vesely J., Willingham M. C. Major DNA fragmentation is a late event in apoptosis. J. Histochem. Cytochem. 45:1997;923-934.
15. Cross S. M., Sanchez C. A., Morgan C. A., Schimke M. K., Ramel S., Idzerda R. L., Raskind W. H., Reid B. J. A p53-dependent mouse spindle checkpoint. Science. 267:1995;1353-1356.
16. Deas O., Dumont C., MacFarlane M., Rouleau M., Hebib C., Harper F., Hirsch F., Charpentier B., Cohen G. M., Senik A. Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T lymphocytes. J. Immunol. 161:1998;3395-3483.
17. Evan G., Littlewood T. A matter of life and cell death. Science. 281:1998;1317-1321.
18. Finkel T. H., Banda N. K. Indirect mechanisms of HIV pathogenesis: how does HIV kill T cells? Curr. Opin. Immunol. 6:1994;605-615.
19. Fletcher T. M., Brichacek B., Sharova N., Newman M. A., Stivahtis G., Sharp P. M., Emerman M., Hahn B. H., Stevenson M. Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(SM). Embo J. 15:1996;6155-6165.
20. Ginsberg D., Michael-Michalovitz D., Ginsberg D., Oren M. Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein. Mol. Cell. Biol. 11:1991;582-585.
21. Goh W. C., Rogel M. E., Kinsey C. M., Michael S. F., Fultz P. N., Nowak M. A., Hahn B. H., Emerman M. HIV-1 Vpr increases viral expression by manipulation of the cell cycle: A mechanism for selection of Vpr in vivo. Nat. Med. 4:1998;65-71.
22. Gougeon M. L., Laurent-Crawford A. G., Hovanessian A. G., Montagnier L. Direct and indirect mechanisms mediating apoptosis during HIV infection: Contribution to in vivo CD4 T cell depletion. Semin. Immunol. 5:1993;187-194.
23. Guillouf C., Rosselli F., Krishnaraju K., Moustacchi E., Hoffman B., Liebermann D. A. p53 involvement in control of G2 exit of the cell cycle: Role in DNA damage-induced apoptosis. Oncogene. 10:1995;2263-2270.
24. Han Z., Chatterjee D., He D. M., Early J., Pantazis P., Wyche J. H., Hendrickson E. A. Evidence for a G2 checkpoint in p53-independent apoptosis induction by X-irradiation. Mol. Cell. Biol. 15:1995;5849-5857.
25. Hartwell L. H., Weinert T. A. Checkpoints: Controls that ensure the order of cell cycle events. Science. 246:1989;629-634.
26. He J., Choe S., Walker R., Di Marzio P., Morgan D. O., Landau N. R. Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity. J. Virol. 69:1995;6705-6711.
27. Hermeking H., Lengauer C., Polyak K., He T. C., Zhang L., Thiagalingam S., Kinzler K. W., Vogelstein B. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol. Cell. 1:1997;3-11.
28. Jowett J. B. M., Planelles V., Poon B., Shah N. P., Chen M. L., Chen I. S. Y. The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle. J. Virol. 69:1995;6304-6313.
29. Kastan M. B., Onyekwere O., Sidransky D., Vogelstein B., Craig R. W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51:1991;6304-6311.
30. Kerr J. F., Wyllie A. H., Currie A. R. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer. 26:1972;239-257.
31. Konopa J. G2 block induced by DNA crosslinking agents and its possible consequences. Biochem. Pharmacol. 39:1988;2303-2309.
32. Lane D. P. Cancer. A death in the life of p53. Nature. 362:1993;786-787.
33. Laurent-Crawford A. G., Krust B., Muller S., Riviere Y., Rey-Cuille M. A., Bechet J. M., Montagnier L., Hovanessian A. G. The cytopathic effect of HIV is associated with apoptosis. Virology. 185:1991;829-839.
34. Levine A. J. p53, the cellular gatekeeper for growth and division. Cell. 88:1997;323-331.
35. Lowe S. W., Ruley H. E., Jacks T., Housman D. E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 74:1993;957-967.
36. Lowe S. W., Schmitt E. M., Smith S. W., Osborne B. A., Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature. 362:1993;847-849.
37. MacFarlane M., Jones N. A., Dive C., Cohen G. M. DNA-damaging agents induce both p53-dependent and p53-independent apoptosis in immature thymocytes. Mol. Pharmacol. 50:1996;900-911.
38. Mahalingam S., MacDonald B., Ugen K. E., Ayyavoo V., Agadjanyan M. G., Williams W. V., Weiner D. B. In vitro and in vivo tumor growth suppression by HIV-1 Vpr. DNA Cell Biol. 16:1997;139-143.
39. Muhlenbeck F., Haas E., Schwenzer R., Schubert G., Grell M., Smith C., Scheurich P., Wajant H. TRAIL/Apo2L activates c-Jun NH2-terminal kinase (JNK) via caspase-dependent and caspase-independent pathways. J. Biol. Chem. 273:1998;33091-33098.
40. Nagata S. Apoptosis by death factor. Cell. 88:1997;355-365.
41. Naldini L., Blomer U., Gallay P., Ory D., Mulligan R., Gage F. H., Verma I. M., Trono D. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science. 272:1996;263-267.
42. O'Connor P. M., Ferris D. K., Pagano M., Draetta G., Pines J., Hunter T., Longo D. L., Kohn K. W. G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J. Biol. Chem. 268:1993;8298-8308.
43. Ogawa K., Shibata R., Kiyomasu T., Higuchi I., Kishida Y., Ishimoto A., Adachi A. Mutational analysis of the human immunodeficiency virus vpr open reading frame. J. Virol. 63:1989;4110-4114.
44. Okuno S., Shimizu S., Ito T., Nomura M., Hamada E., Tsujimoto Y., Matsuda H. Bcl-2 Prevents Caspase-independent Cell Death. J. Biol. Chem. 273:1998;34272-34277.
45. Paulovich A. G., Toczyski D. P., Hartwell L. H. When checkpoints fail. Cell. 88:1997;315-321.
46. Planelles V., Jowett J. B. M., Li Q. X., Xie Y., Hahn B., Chen I. S. Y. Vpr-induced cell cycle arrest is conserved among primate lentiviruses. J. Virol. 70:1996;2516-2524.
47. Re F., Braaten D., Franke E. K., Luban J. Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B. J. Virol. 69:1995;6859-6864.
48. Rogel M. E., Wu L. I., Emerman M. The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection. J. Virol. 69:1995;882-888.
49. Stewart N., Hicks G. G., Paraskevas F., Mowat M. Evidence for a second cell cycle block at G2/M by p53. Oncogene. 10:1995;109-115.
50. Stewart S. A., Poon B., Jowett J. B., Chen I. S. Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest. J. Virol. 71:1997;5579-5592.
51. Strasser A., Harris A. W., Jacks T., Cory S. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell. 79:1994;329-339.
52. Subramanian T., Tarodi B., Chinnadurai G. p53-independent apoptotic and necrotic cell deaths induced by adenovirus infection: Suppression by E1B 19K and Bcl-2 proteins. Cell Growth Differ. 6:1995;131-137.
53. Terai C., Kornbluth R. S., Pauza C. D., Richman D. D., Carson D. A. Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1. J. Clin. Invest. 87:1991;1710-1715.
54. Vaux D. L., Strasser A. The molecular biology of apoptosis. Proc. Natl. Acad. Sci. USA. 93:1996;2239-2244.
55. White S. M., Renda M. J., Nam N., Klimatcheva K., Zhu Y., Fisk J., Halterman M., Rimel B. J., Federoff H. J., Pandya S., Rosenblatt J. D., Planelles V. Lentiviral vectors using human and simian immunodeficiency virus elements. J. Virol. 73:1999;2823-2840.
56. Yonish-Rouach E., Resnitzky D., Lotem J., Sachs L., Kimchi A., Oren M. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature. 352:1991;345-347.
57. Yu Y., Little J. B. p53 is involved in but not required for ionizing radiation-induced caspase-3 activation and apoptosis in human lymphoblast cell lines. Cancer Res. 58:1998;4277-4281.