Cell cycle arrest in G2/M promotes early steps of infection by human immunodeficiency virus

Journal of Virology

Volumn 79, Issue 9, 2005, Pages 5695-5704

  Groschel, Bettina ^a,b   Bushman, Frederic ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APHIDICOLIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CAMPTOTHECIN; DNA POLYMERASE; DNA TOPOISOMERASE; ETOPOSIDE; PACLITAXEL; PROTEASOME INHIBITOR; VIRUS DNA; VIRUS VECTOR;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL STIMULATION; CELL TRANSFORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONG TERMINAL REPEAT; LUNG FIBROBLAST; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; PROVIRUS; VIRUS CELL INTERACTION; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

APHIDICOLIN; CAMPTOTHECIN; CELL CYCLE; CELL DIVISION; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ETOPOSIDE; G2 PHASE; HIV; HIV INFECTIONS; HUMANS; NUCLEIC ACID SYNTHESIS INHIBITORS; PACLITAXEL; TIME FACTORS; TRANSDUCTION, GENETIC; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 17444373533     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.9.5695-5704.2005     Document Type: Article

References (23)

1. Butler, S., M. Hansen, and F. D. Bushman. 2001. A Quantitative assay for HIV cDNA integration in vivo. Nat. Med. 7:631-634.
2. Butler, S. L., E. P. Johnson, and F. D. Bushman. 2002. Human immunodeficiency virus cDNA metabolism: notable stability of two-long terminal repeat circles. J. Virol. 76:3739-3747.
3. Chowdhury, I. H., X. F. Wang, N. R. Landau, M. L. Robb, V. R. Polonis, D. L. Birx, and J. H. Kim. 2003. HIV-1 Vpr activates cell cycle inhibitor p21/Waf1/ Cip1: a potential mechanism of G2/M cell cycle arrest. Virology 305:371-377.
4. de Noronha, C. M., M. P. Sherman, H. W. Lin, M. Cavrois, R. D. Moir, R. D. Goldman, and W. C. Greene. 2001. Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. Science 294:1105-1108.
5. Goh, W. C., N. Manel, and M. Emerman. 2004. The human immunodeficiency virus Vpr protein binds Cdc25C: implications for G2 arrest. Virology 318:337-349.
6. Goh, W. C., M. E. Rogel, C. M. Kinsey, S. F. Michael, P. N. Fultz, M. A. Nowak, B. H. Hahn, and M. Emerman. 1998. HIV-1 Vpr increases viral expression by manipulation of the cell cycle: a mechanism for selection of Vpr in vivo. Nat. Med. 4:65-71.
7. 2. J. Virol. 72:8174-8180.
8. Hansen, M. S. T., G. J. I. Smith, T. Kafri, V. Molteni, J. S. Siegel, and F. D. Bushman. 1999. Integration complexes derived from HIV vectors for rapid assays in vitro. Nat. Biotechnol. 17:578-582.
9. 2 phase of the cell cycle by inhibiting p34cdc2 activity. J. Virol. 69:6705-6711.
10. Jeanson, L., F. Subra, S. Vaganay, M. Hervy, E. Marangoni, J. Bourhis, and J. F. Mouscadet. 2002. Effect of Ku80 depletion on the preintegrative steps of HIV-1 replication in human cells. Virology 300:100-108.
11. Jordan, A., P. Defechereux, and E. Verdin. 2001. The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation. EMBO J. 20:1726-1738.
12. Kim, O. H., J. H. Lim, K. J. Woo, Y. H. Kim, I. N. Jin, S. T. Han, J. W. Park, and T. K. Kwon. 2004. Influence of p53 and p21Waf1 expression on G2/M phase arrest of colorectal carcinoma HCT116 cells to proteasome inhibitors. Int. J. Oncol. 24:935-941.
13. Kornberg, A., and T. Baker. 1991. DNA replication. W. H. Freeman and Company, New York, N.Y.
14. Li, L., J. M. Olvera, K. Yoder, R. S. Mitchell, S. L. Butler, M. R. Lieber, S. L. Martin, and F. D. Bushman. 2001. Role of the non-homologous DNA end joining pathway in retroviral infection. EMBO J. 20:3272-3281.
15. O'Doherty, U., W. J. Swiggard, and M. H. Malim. 2000. Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding. J. Virol. 74:10074-10080.
16. Poon, B., and I. S. Chen. 2003. Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression from unintegrated HIV-1 DNA. J. Virol. 77:3962-3972.
17. Re, F., and J. Luban. 1997. HIV-1 Vpr: G2 cell cycle arrest, macrophages and nuclear transport. Prog. Cell Cycle Res. 3:21-27.
18. Schwartz, O., V. Marechal, B. Friguet, F. Arenzana-Seisdedos, and J.-M. Heard. 1998. Antiviral activity of the proteasome on incoming human immunodeficiency virus type 1. J. Virol. 72:3845-3850.
19. Sharkey, M. E., I. Teo, T. Greenough, N. Sharova, K. Luzuriaga, J. L. Sullivan, R. P. Bucy, L. G. Kostrikis, A. Haase, C. Veryard, R. E. Davaro, S. H. Cheeseman, J. S. Daly, C. Bova, R. T. I. Ellision, B. Mady, K. K. Lai, G. Moyle, M. Nelson, B. Gazzard, S. Shaunak, and M. Stevenson. 2000. Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy. Nat. Med. 6:76-81.
20. Sheeny, A. M., N. C. Gaddis, J. D. Choi, and M. H. Malim. 2002. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 418:646-650.
21. Stremlau, M., C. M. Owens, M. J. Perron, M. Kiessling, P. Autissier, and J. Sodroski. 2004. The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys. Nature 427:848-853.
22. Tusher, V. G., R. Tibshirani, and G. Chu. 2001. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. USA 98:5116-5121.
23. 2 arrest. J. Virol. 78:8183-8190.