Involvement of mammalian Mus81 in genome integrity and tumor suppression

Science

Volumn 304, Issue 5678, 2004, Pages 1822-1826

  McPherson, John Peter ^a,b   Lemmers, Bénédicte ^a,b   Chahwan, Richard ^a,b   Pamidi, Ashwin ^a,b   Migon, Eva ^a,b   Matysiak Zablocki, Elzbieta ^a,b   Moynahan, Mary Ellen ^c   Essers, Jeroen ^d   Hanada, Katsuhiro ^d   Poonepalli, Anuradha ^e   Sanchez Sweatman, Otto ^b   Khokha, Rama ^b   Kanaar, Roland ^d   Jasin, Maria ^c   Hande, M Prakash ^e   Hakem, Razqallah ^a,b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMES; CROSSLINKING; DNA; GAMMA RAYS; SENSITIVITY ANALYSIS; TUMORS; YEAST;

GENOME INTEGRITY; MAMMALS; TUMOR SUPPRESSION;

GENES;

CELL DNA; EME1 ENDONUCLEASE; ENDONUCLEASE; MITOMYCIN C; UNCLASSIFIED DRUG;

BIOLOGY;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHROMOSOME DAMAGE; COMPLEX FORMATION; CONTROLLED STUDY; DNA CROSS LINKING; FEMALE; GAMMA IRRADIATION; GENE FUNCTION; GENE REPLICATION; GENE STRUCTURE; GENETIC RECOMBINATION; HETEROZYGOTE; HOMOZYGOTE; MALE; MAMMALIAN GENETICS; MEIOSIS; MOUSE; MUS81 GENE; NONHUMAN; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ALLELES; ANIMALS; CHROMOSOME ABERRATIONS; DNA DAMAGE; DNA-BINDING PROTEINS; EMBRYO; EMBRYONIC AND FETAL DEVELOPMENT; ENDONUCLEASES; GAMMA RAYS; GENE TARGETING; GENETIC PREDISPOSITION TO DISEASE; GENOME; GENOMIC INSTABILITY; HETEROZYGOTE; LYMPHOMA; MEIOSIS; MICE; MITOMYCIN; NEOPLASMS; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE PROTEINS; SISTER CHROMATID EXCHANGE; STEM CELLS; T-LYMPHOCYTES;

ANIMALIA; MAMMALIA;

EID: 2942746374     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1094557     Document Type: Article

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29. We thank S. West, A. Ciccia, J. Abraham, and A. Hakem for helpful discussions and for reviewing the manuscript; A. Shehabeldin, J. Ho, D. Bouchard, A. Wakeham, and S. Plyte for technical assistance; and R. Laister, S. Duan, and C. Arrowsmith for sharing reagents. We also thank S. West and A. Ciccia for the antiserum against N-terminal Mus81. J.P.M. was supported by a Canadian Institute of Health Research Fellowship. M.P.H. is supported by start-up grants from the National University of Singapore (NUS); the Oncology Research Institute, National University Medical Institute (NUMI), Singapore; and a grant from the Academic Research Fund, Faculty of Medicine, NUS, Singapore. This work was supported by Amgen, Inc., the National Cancer Institute of Canada, and the Canadian Institute of Health Research (R.H.).