Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signaling

Journal of Neuroscience

Volumn 28, Issue 26, 2008, Pages 6539-6548

  Naidoo, Nirinjini ^a   Ferber, Megan ^a   Master, Monali ^a   Zhu, Yan ^a   Pack, Allan I ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Aging; Apoptotic signaling; BiP; ER stress; Sleep deprivation; UPR

Indexed keywords

CASPASE 12; CCAAT ENHANCER BINDING PROTEIN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 34; INITIATION FACTOR 2ALPHA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CELL CYCLE PROTEIN; CHAPERONE; DIFFERENTIATION ANTIGEN; HEAT SHOCK PROTEIN; INITIATION FACTOR 2; MOLECULAR CHAPERONE GRP78; PPP1R15A PROTEIN, MOUSE;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; ENZYME ACTIVATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SLEEP DEPRIVATION; ADAPTATION; ANIMAL; BRAIN; C57BL MOUSE; DISEASE MODEL; ENDOPLASMIC RETICULUM; METABOLISM; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN FOLDING; UPREGULATION;

ADAPTATION, PHYSIOLOGICAL; AGING; ANIMALS; ANTIGENS, DIFFERENTIATION; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BRAIN; CELL CYCLE PROTEINS; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; HEAT-SHOCK PROTEINS; MALE; MICE; MICE, INBRED C57BL; MOLECULAR CHAPERONES; OXIDATIVE STRESS; PROTEIN FOLDING; SIGNAL TRANSDUCTION; SLEEP DEPRIVATION; UP-REGULATION;

EID: 48549090526     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5685-07.2008     Document Type: Article

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